4.5 Review

Sulbactam-durlobactam: A novel β-lactam-β-lactamase inhibitor combination targeting carbapenem-resistant Acinetobacter baumannii infections

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Summary: Sulbactam-durlobactam is a combination of beta-lactam and beta-lactamase inhibitor that is being developed for the treatment of Acinetobacter infections, including multidrug-resistant strains. Sulbactam has intrinsic antibacterial activity against Acinetobacter, but its effectiveness has been reduced by increasing beta-lactamase-mediated resistance. Durlobactam, a rationally designed beta-lactamase inhibitor, effectively restores susceptibility to resistant isolates when combined with sulbactam. This review discusses the pharmacokinetic/pharmacodynamic relationship of the combination in nonclinical infection models and aids in determining effective dose regimens for humans.

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Summary: Durlobactam is a drug that inhibits various beta-lactamases and has low risk of prolonging the QT interval, making it unlikely to produce proarrhythmic effects when used, especially in combination with sulbactam against carbapenem- and colistin-resistant Acinetobacter baumannii.

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Carbapenem resistance in Acinetobacter baumannii, and their importance in hospital-acquired infections: a scientific review

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Durlobactam, a New Diazabicyclooctane β-Lactamase Inhibitor for the Treatment of Acinetobacter Infections in Combination With Sulbactam

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