Molecular mechanisms and targets of right ventricular fibrosis in pulmonary hypertension

Right ventricular fibrosis is a stress response, predominantly mediated by cardiac fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory cytokines, pro-fibrotic growth factors and mechanical stimulation. Activation of fibroblasts results in the induction of various molecular signaling pathways, most notably the mitogen-activated protein kinase cassettes, leading to increased synthesis and remodeling of the extracellular matrix. While fibrosis confers structural protection in response to damage induced by ischemia or (pressure and volume) overload, it simultaneously contributes to increased myocardial stiffness and right ven-tricular dysfunction. Here, we review state-of-the-art knowledge of the development of right ventricular fibrosis in response to pressure overload and provide an overview of all published preclinical and clinical studies in which right ventricular fibrosis was targeted to improve cardiac function. (c) 2023 Published by Elsevier Inc.

Automated summary

Right ventricular fibrosis is a stress response caused by activation of cardiac fibroblasts, leading to increased synthesis and remodeling of the extracellular matrix. While it provides structural protection in response to damage, it also contributes to increased myocardial stiffness and dysfunction. This review summarizes current knowledge and studies on the development of right ventricular fibrosis in response to pressure overload and its potential for improving cardiac function. (c) 2023 Published by Elsevier Inc.