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Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases
Shruthi Vaidhyanathan et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma
Laurent Salphati et al.
DRUG METABOLISM AND DISPOSITION (2016)
Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
Hisham Qosa et al.
BRAIN RESEARCH (2015)
Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells
Jessian L. Munoz et al.
CANCER LETTERS (2015)
Synthetic miR-145 Mimic Enhances the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma
Hongwei Liu et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2015)
Cyclooxygenase-2 inhibitor prevents radiation-enhanced infiltration of F98 glioma cells in brain of Fischer rat
Guillaume Desmarais et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2015)
The TNF-α/NF-κB signaling pathway has a key role in methamphetamine-induced blood-brain barrier dysfunction
Vanessa Coelho-Santos et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)
Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels
Margaret E. Tome et al.
JOURNAL OF NEUROCHEMISTRY (2015)
In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator-activated receptor alpha (Pparα) at the blood-brain barrier
Md. Tozammel Hoque et al.
JOURNAL OF NEUROCHEMISTRY (2015)
Breast Cancer Resistance Protein and P-Glycoprotein Influence In Vivo Disposition of 11C-Erlotinib
Alexander Traxl et al.
JOURNAL OF NUCLEAR MEDICINE (2015)
Effect and mechanism of peroxisome proliferator-activated receptor-γ on the drug resistance of the U-87 MG/CDDP human malignant glioma cell line
Shaorong Han et al.
MOLECULAR MEDICINE REPORTS (2015)
The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1
Begum G. Akkaya et al.
MOLECULAR MEMBRANE BIOLOGY (2015)
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Lin Zhang et al.
NATURE (2015)
Immune attack: the role of inflammation in Alzheimer disease
Frank L. Heppner et al.
NATURE REVIEWS NEUROSCIENCE (2015)
P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations
Catherine Chiu et al.
NEUROBIOLOGY OF AGING (2015)
Regulation of Human Hepatic Drug Transporter Activity and Expression by Diesel Exhaust Particle Extract
Marc Le Vee et al.
PLOS ONE (2015)
Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation
Natalya Korogod et al.
ELIFE (2015)
Efflux transporters in blood-brain interfaces of the developing brain
Nathalie Strazielle et al.
FRONTIERS IN NEUROSCIENCE (2015)
Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice
David A. Hartmann et al.
NEUROPHOTONICS (2015)
A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability
Do-Geun Kim et al.
MOLECULAR NEUROBIOLOGY (2015)
In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice
Kazuto Yasuda et al.
DRUG METABOLISM AND DISPOSITION (2015)
Circadian Modulation in the Intestinal Absorption of P-Glycoprotein Substrates in Monkeys
Masaru Iwasaki et al.
MOLECULAR PHARMACOLOGY (2015)
Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain
Laura Kervezee et al.
AAPS JOURNAL (2014)
Microglial dysfunction in brain aging and Alzheimer's disease
Kira Irving Mosher et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation
J. J. M. A. Hendrikx et al.
BRITISH JOURNAL OF CANCER (2014)
Current advances on ABC drug transporters in fish
Till Luckenbach et al.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2014)
Signaling Pathways that Regulate Basal ABC Transporter Activity at the Blood-Brain Barrier
David S. Miller et al.
CURRENT PHARMACEUTICAL DESIGN (2014)
TGF-β1 Regulation of Multidrug Resistance P-glycoprotein in the Developing Male Blood-Brain Barrier
Stephanie Baello et al.
ENDOCRINOLOGY (2014)
Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease
Zhiyou Cai et al.
INTERNATIONAL JOURNAL OF NEUROSCIENCE (2014)
The Impact of Hemi-brain Irradiation on Accumulation of PI3K/mTOR Inhibitors With Limited (GDC-0980) and Robust (GNE-317) Blood-Brain Barrier Penetration
T. T. Sio et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2014)
The multiple facets of drug resistance: one history, different approaches
Evandro Luis Niero et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)
Hyperammonemia enhances the function and expression of P-glycoprotein and Mrp2 at the blood brain barrier through NF-κB
Ji Zhang et al.
JOURNAL OF NEUROCHEMISTRY (2014)
Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers
Xueqian Wang et al.
JOURNAL OF NEUROSCIENCE (2014)
Temozolomide Induces the Production of Epidermal Growth Factor to Regulate MDR1 Expression in Glioblastoma Cells
Jessian L. Munoz et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Crystal structure of the human glucose transporter GLUT1
Dong Deng et al.
NATURE (2014)
Remodelling the extracellular matrix in development and disease
Caroline Bonnans et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy
Anna Carrano et al.
NEUROBIOLOGY OF AGING (2014)
PTEN Regulates BCRP/ABCG2 and the Side Population through the PI3K/Akt Pathway in Chronic Myeloid Leukemia
Fang-Fang Huang et al.
PLOS ONE (2014)
Insulin suppresses the expression and function of breast cancer resistance protein in primary cultures of rat brain microvessel endothelial cells
Liu Xiang Liu et al.
Pharmacological Reports (2014)
For pediatric glioma, leave no histone unturned
Oren J. Becher et al.
SCIENCE (2014)
Optimization of irinotecan chronotherapy with P-glycoprotein inhibition
Elisabeth Filipski et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)
The xenoestrogens ethinylestradiol and bisphenol A regulate BCRP at the blood-brain barrier of rats
Sabrina Nickel et al.
XENOBIOTICA (2014)
The pivotal role of astrocytes in an in vitro stroke model of the blood-brain barrier
Winfried Neuhaus et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Aβ1-42 reduces P-glycoprotein in the blood-brain barrier through RAGE-NF-κB signaling
R. Park et al.
CELL DEATH & DISEASE (2014)
VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets
Abid Qureshi et al.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2014)
The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history
Norman R. Saunders et al.
FRONTIERS IN NEUROSCIENCE (2014)
Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
Michael R. Jablonski et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2014)
Blood-Brain Barrier Pharmacoproteomics-Based Reconstruction of the In Vivo Brain Distribution of P-Glycoprotein Substrates in Cynomolgus Monkeys
Yasuo Uchida et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
Implanted Carmustine Wafers Followed by Concomitant Radiochemotherapy to Treat Newly Diagnosed Malignant Gliomas: Prospective, Observational, Multicenter Study on 92 Cases
Julien Duntze et al.
ANNALS OF SURGICAL ONCOLOGY (2013)
Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells
V. Martin et al.
BRITISH JOURNAL OF CANCER (2013)
The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model
Christian Grommes et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2013)
Inactivation of PTEN increases ABCG2 expression and the side population through the PI3K/Akt pathway in adult acute leukemia
Fang-Fang Huang et al.
CANCER LETTERS (2013)
The Somatic Genomic Landscape of Glioblastoma
Cameron W. Brennan et al.
CELL (2013)
Brain Metastases from Renal Cell Carcinoma in the Era of Tyrosine Kinase Inhibitors
Arkadiusz Z. Dudek et al.
CLINICAL GENITOURINARY CANCER (2013)
Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer's Disease: A New Approach to Therapy
Marta Sochocka et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2013)
Glial Influence on the Blood Brain Barrier
Jorge Ivan Alvarez et al.
GLIA (2013)
P-Glycoprotein, Breast Cancer Resistance Protein, Organic Anion Transporter 3, and Transporting Peptide 1a4 during Blood-Brain Barrier Maturation: Involvement of Wnt/β-Catenin and Endothelin-1 Signaling
Rania Harati et al.
MOLECULAR PHARMACEUTICS (2013)
Dynamic Regulation of P-glycoprotein in Human Brain Capillaries
Janine Avemary et al.
MOLECULAR PHARMACEUTICS (2013)
Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/-catenin pathway
Chiara Riganti et al.
NEURO-ONCOLOGY (2013)
Consequences of Repeated Blood-Brain Barrier Disruption in Football Players
Nicola Marchi et al.
PLOS ONE (2013)
In Vitro Drug Response and Efflux Transporters Associated with Drug Resistance in Pediatric High Grade Glioma and Diffuse Intrinsic Pontine Glioma
Susanna J. E. Veringa et al.
PLOS ONE (2013)
Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro
Roberta Paolinelli et al.
PLOS ONE (2013)
Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches
Caitlin Lynch et al.
PHARMACEUTICAL RESEARCH (2013)
Altered Brain Uptake of Therapeutics in a Triple Transgenic Mouse Model of Alzheimer's Disease
Dharmini C. Mehta et al.
PHARMACEUTICAL RESEARCH (2013)
ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein
David Dickens et al.
PHARMACOGENETICS AND GENOMICS (2013)
Role of nuclear receptors in the regulation of drug transporters in the brain
Gary N. Y. Chan et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients
Marc Delord et al.
ONCOTARGET (2013)
P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model
Chris E. Adkins et al.
FRONTIERS IN PHARMACOLOGY (2013)
Brain Efflux Index To Investigate the Influence of Active Efflux on Brain Distribution of Pemetrexed and Methotrexate
Li Li et al.
DRUG METABOLISM AND DISPOSITION (2013)
Acetaminophen Modulates P-Glycoprotein Functional Expression at the Blood-Brain Barrier by a Constitutive Androstane Receptor-Dependent Mechanism
Lauren M. Slosky et al.
MOLECULAR PHARMACOLOGY (2013)
Role of CNS efflux drug transporters in antiepileptic drug delivery: Overcoming CNS efflux drug transport
Heidrun Potschka
ADVANCED DRUG DELIVERY REVIEWS (2012)
Effects of Rifampicin, Dexamethasone, St. John's Wort and Thyroxine on Maternal and Foetal Expression of Abcb1 and Organ Distribution of Talinolol in Pregnant Rats
Karen Salje et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)
Blood-brain barrier P-glycoprotein function in Alzheimer's disease
Danielle M. E. van Assema et al.
BRAIN (2012)
Circadian Variations in Exsorptive Transport: In Situ Intestinal Perfusion Data and In Vivo Relevance
Alper Okyar et al.
CHRONOBIOLOGY INTERNATIONAL (2012)
The Androgen Metabolite, 5α-androstane-3β,17β-diol, Decreases Cytokine-Induced Cyclooxygenase-2, Vascular Cell Adhesion Molecule-1 Expression, and P-Glycoprotein Expression in Male Human Brain Microvascular Endothelial Cells
Kristen L. Zuloaga et al.
ENDOCRINOLOGY (2012)
Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP
Nienke A. de Vries et al.
INVESTIGATIONAL NEW DRUGS (2012)
ABC transporter function and regulation at the blood-spinal cord barrier
Christopher R. Campos et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)
Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation
Salah Yousif et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Susceptibility of juvenile and adult blood-brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity
Rania Harati et al.
JOURNAL OF NEUROINFLAMMATION (2012)
ABC transporters of antimicrobial peptides in Firmicutes bacteria - phylogeny, function and regulation
Susanne Gebhard
MOLECULAR MICROBIOLOGY (2012)
Insight into the Cooperation of P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) at the Blood-Brain Barrier: A Case Study Examining Sorafenib Efflux Clearance
Sagar Agarwal et al.
MOLECULAR PHARMACEUTICS (2012)
Endogenous viruses: insights into viral evolution and impact on host biology
Cedric Feschotte et al.
NATURE REVIEWS GENETICS (2012)
Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS
Michael R. Jablonski et al.
NEUROBIOLOGY OF DISEASE (2012)
Pro-Inflammatory Cytokine Regulation of P-glycoprotein in the Developing Blood-Brain Barrier
Majid Iqbal et al.
PLOS ONE (2012)
Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer
Kunal S. Taskar et al.
PHARMACEUTICAL RESEARCH (2012)
Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain
Ronald E. Cannon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Amyloid-β Contributes to Blood-Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy
Anika M. S. Hartz et al.
STROKE (2012)
Inflammation in Alzheimer Disease-A Brief Review of the Basic Science and Clinical Literature
Tony Wyss-Coray et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression
Takeo Nakanishi et al.
CHINESE JOURNAL OF CANCER (2012)
ABC Transporters and the Alzheimer’s Disease Enigma
Andrea Wolf et al.
Frontiers in Psychiatry (2012)
Brain Distribution and Bioavailability of Elacridar after Different Routes of Administration in the Mouse
Ramola Sane et al.
DRUG METABOLISM AND DISPOSITION (2012)
Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice
Lauren M. Aleksunes et al.
DRUG METABOLISM AND DISPOSITION (2012)
Regulation of Breast Cancer Resistant Protein by Peroxisome Proliferator-Activated Receptor α in Human Brain Microvessel Endothelial Cells
Md. Tozammel Hoque et al.
MOLECULAR PHARMACOLOGY (2012)
Resolving postoperative neuroinflammation and cognitive decline
Niccolo Terrando et al.
ANNALS OF NEUROLOGY (2011)
The resurgence of A2B adenosine receptor signaling
Carol M. Aherne et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)
The ABCG2 resistance network of glioblastoma
Anne-Marie Bleau et al.
CELL CYCLE (2011)
ABC Transporters in the CNS – An Inventory
A. M.S. Hartz et al.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2011)
Extracellular Matrix and Matrix Receptors in Blood-Brain Barrier Formation and Stroke
Kim M. Baeten et al.
DEVELOPMENTAL NEUROBIOLOGY (2011)
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
Markus Krohn et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
Yasuo Uchida et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells
Gary N. Y. Chan et al.
JOURNAL OF NEUROCHEMISTRY (2011)
The Case for Blood-Brain Barrier Dysfunction in the Pathogenesis of Alzheimer's Disease
Brian Jeynes et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2011)
Regulation of P-Glycoprotein by Human Immunodeficiency Virus-1 in Primary Cultures of Human Fetal Astrocytes
Tamima Ashraf et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2011)
Quantitative Membrane Protein Expression at the Blood-Brain Barrier of Adult and Younger Cynomolgus Monkeys
Katsuaki Ito et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Inflammatory Pain Signals an Increase in Functional Expression of Organic Anion Transporting Polypeptide 1a4 at the Blood-Brain Barrier
Patrick T. Ronaldson et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain
Sagar Agarwal et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Central nervous system pericytes in health and disease
Ethan A. Winkler et al.
NATURE NEUROSCIENCE (2011)
An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis
Brian Jeynes et al.
NEUROSCIENCE LETTERS (2011)
Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier
Alison Burgess et al.
PLOS ONE (2011)
Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET
Pavitra Kannan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence
Jorge Ivan Alvarez et al.
SCIENCE (2011)
Neuropathological Alterations in Alzheimer Disease
Alberto Serrano-Pozo et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)
Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole
Shin-ichi Akanuma et al.
FLUIDS AND BARRIERS OF THE CNS (2011)
Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor
Florian Bauer et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Phylogenetic analysis of fungal ABC transporters
Andriy Kovalchuk et al.
BMC GENOMICS (2010)
Developmental expression of multidrug resistance phosphoglycoprotein (P-gp) in the mouse fetal brain and glucocorticoid regulation
Sophie Petropoulos et al.
BRAIN RESEARCH (2010)
ABC efflux transporters in brain vasculature of Alzheimer's subjects
Hasini C. Wijesuriya et al.
BRAIN RESEARCH (2010)
Transcriptional modulation of BCRP gene to reverse multidrug resistance by toremifene in breast adenocarcinoma cells
Yuhua Zhang et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy
J. Schlichtiger et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Roel G. W. Verhaak et al.
CANCER CELL (2010)
Cell Signaling by Receptor Tyrosine Kinases
Mark A. Lemmon et al.
CELL (2010)
Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood-Brain Barrier
Birk Poller et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2010)
The Role of Cerebral Vascular NF kappa B in LPS-induced Inflammation: Differential Regulation of Efflux Transporter and Transporting Cytokine Receptors
Weihong Pan et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2010)
Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer
Paul R. Lockman et al.
CLINICAL CANCER RESEARCH (2010)
The Perivascular Astroglial Sheath Provides a Complete Covering of the Brain Microvessels: An Electron Microscopic 3D Reconstruction
Thomas Misje Mathiisen et al.
GLIA (2010)
Regulation of P-Glycoprotein in Renal Proximal Tubule Epithelial Cells by LPS and TNF-alpha
Suzanne Heemskerk et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)
Activation of PKC isoform βI at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain
Robert R. Rigor et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)
17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity
Anika M. S. Hartz et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)
Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay
Brian T. Hawkins et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)
Localization of Drug-Metabolizing Enzyme Activities to Blood-Brain Interfaces and Circumventricular Organs
J. F. Ghersi-Egea et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Estrogen Receptor β Signaling through Phosphatase and Tensin Homolog/Phosphoinositide 3-Kinase/Akt/Glycogen Synthase Kinase 3 Down-Regulates Blood-Brain Barrier Breast Cancer Resistance Protein
A. M. S. Hartz et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Breast Cancer Resistance Protein and P-glycoprotein Limit Sorafenib Brain Accumulation
Jurjen S. Lagas et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Regulation of ABC Transporters at the Blood-Brain Barrier: New Targets for CNS Therapy
Anika M. S. Hartz et al.
MOLECULAR INTERVENTIONS (2010)
Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier
Xueqian Wang et al.
MOLECULAR PHARMACOLOGY (2010)
Regulation of Multidrug Resistance Protein 1 by Tumor Necrosis Factor α in Cultured Glial Cells: Involvement of Nuclear Factor-κB and c-Jun N-Terminal Kinase Signaling Pathways
Patrick T. Ronaldson et al.
MOLECULAR PHARMACOLOGY (2010)
Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-β in a Mouse Model of Alzheimer's Disease
Anika M. S. Hartz et al.
MOLECULAR PHARMACOLOGY (2010)
Pericytes regulate the blood-brain barrier
Annika Armulik et al.
NATURE (2010)
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats
Erwin A. van Vliet et al.
NEUROPHARMACOLOGY (2010)
ALTERATIONS IN BRAIN ANTIOXIDANT ENZYMES AND REDOX PROTEOMIC IDENTIFICATION OF OXIDIZED BRAIN PROTEINS INDUCED BY THE ANTI-CANCER DRUG ADRIAMYCIN: IMPLICATIONS FOR OXIDATIVE STRESS-MEDIATED CHEMOBRAIN
G. Joshi et al.
NEUROSCIENCE (2010)
The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells
Richard Daneman et al.
PLOS ONE (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
Apolipoprotein E Controls ATP-Binding Cassette Transporters in the Ischemic Brain
Ayman ElAli et al.
SCIENCE SIGNALING (2010)
The Human Breast Cancer Resistance Protein (BCRP/ABCG2) Shows Conformational Changes with Mitoxantrone
Mark F. Rosenberg et al.
STRUCTURE (2010)
Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier
David S. Miller
TRENDS IN PHARMACOLOGICAL SCIENCES (2010)
ABCG2: A perspective
Robert W. Robey et al.
ADVANCED DRUG DELIVERY REVIEWS (2009)
Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells
Sandrine Dauchy et al.
BIOCHEMICAL PHARMACOLOGY (2009)
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function
King Leung Fung et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)
Decreased expression of multidrug efflux transporters in the brains of GSK-3β transgenic mice
Joseph C. Lim et al.
BRAIN RESEARCH (2009)
PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells
Anne-Marie Bleau et al.
CELL STEM CELL (2009)
Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment
Jurjen S. Lagas et al.
CLINICAL CANCER RESEARCH (2009)
A Phase I Study of the P-Glycoprotein Antagonist Tariquidar in Combination with Vinorelbine
Jame Abraham et al.
CLINICAL CANCER RESEARCH (2009)
Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks
Diane Palmieri et al.
CLINICAL CANCER RESEARCH (2009)
An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016)
Joseph W. Polli et al.
DRUG METABOLISM AND DISPOSITION (2009)
SIGNALING TO P-GLYCOPROTEIN-A NEW THERAPEUTIC TARGET TO TREAT DRUG-RESISTANT EPILEPSY?
Anika M. S. Hartz et al.
DRUG NEWS & PERSPECTIVES (2009)
Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
Karsten Ulbrich et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2009)
Insulin regulates P-glycoprotein in rat brain microvessel endothelial cells via an insulin receptor-mediated PKC/NF-κB pathway but not a PI3K/Akt pathway
Haiyan Liu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
Compensatory Role of P-Glycoproteins in Knockout Mice Lacking the Bile Salt Export Pump
Renxue Wang et al.
HEPATOLOGY (2009)
New findings on melatonin absorption and alterations by pharmaceutical excipients using the Ussing chamber technique with mounted rat gastrointestinal segments
Huyen Thi Thanh Tran et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)
Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience
Lilyana Angelov et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood-Brain Barrier
Bernd Doerner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitro
Magdalena von Wedel-Parlow et al.
JOURNAL OF NEUROCHEMISTRY (2009)
ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood-Brain Barrier for Aβ1-40 Peptides
Huaqi Xiong et al.
JOURNAL OF NEUROSCIENCE (2009)
A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)[11C]verapamil and PET
Claudia Wagner et al.
JOURNAL OF NUCLEAR MEDICINE (2009)
Targeting Prostaglandin E2 EP1 Receptors Prevents Seizure-Associated P-glycoprotein Up-Regulation
Anton Pekcec et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
P-glycoprotein and Breast Cancer Resistance Protein Influence Brain Distribution of Dasatinib
Ying Chen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition
Guido Zibell et al.
NEUROPHARMACOLOGY (2009)
Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations
Tomoka Furukawa et al.
PHARMACEUTICAL RESEARCH (2009)
Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer
Fancy C. Thomas et al.
PHARMACEUTICAL RESEARCH (2009)
The Extracellular Matrix: Not Just Pretty Fibrils
Richard O. Hynes
SCIENCE (2009)
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Stephen G. Aller et al.
SCIENCE (2009)
A2B adenosine receptors in immunity and inflammation
Gyoergy Hasko et al.
TRENDS IN IMMUNOLOGY (2009)
A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-glycoprotein at the Human Blood-Brain Barrier with (R)-C-11-Verapamil and PET
Claudia C. Wagner et al.
JOURNAL OF NUCLEAR MEDICINE (2009)
Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier
Vishal S. Narang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)
Tariquidar, a Selective P-glycoprotein Inhibitor, Does Not Potentiate Loperamide's Opioid Brain Effects in Humans despite Full Inhibition of Lymphocyte P-glycoprotein
Daniel Kurnik et al.
ANESTHESIOLOGY (2008)
ABCC1: a gateway for pharmacological compounds to the ischaemic brain
Ertugrul Kilic et al.
BRAIN (2008)
Clinico-pathologic function of cerebral ABC transporters - Implications for the pathogenesis of Alzheimer's disease
Jens Pahnke et al.
CURRENT ALZHEIMER RESEARCH (2008)
Circadian Clock-Controlled Intestinal Expression of the Multidrug-Resistance Gene mdr1a in Mice
Yuichi Murakami et al.
GASTROENTEROLOGY (2008)
Regulation of ABC Membrane Transporters in Glial Cells: Relevance to the Pharmacotherapy of Brain HIV-1 Infection
Patrick T. Ronaldson et al.
GLIA (2008)
Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTπ, at the blood-brain barrier
Bjoern Bauer et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)
Effect of chronic exposure to morphine on the rat blood-brain barrier: focus on the P-glycoprotein
Salah Yousif et al.
JOURNAL OF NEUROCHEMISTRY (2008)
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier
Sandrine Dauchy et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET
Jens P. Bankstahl et al.
JOURNAL OF NUCLEAR MEDICINE (2008)
Expression of MDR1, MRP2 and BCRP mRNA in tissues of Turkeys
A. M. Haritova et al.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS (2008)
Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling
Bjoern Bauer et al.
MOLECULAR PHARMACOLOGY (2008)
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
L. Chin et al.
NATURE (2008)
Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier
Shin-Ichi Akanuma et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
Reversion of multidrug resistance in human glioma by RNA interference
Peng Zhao et al.
NEUROLOGICAL RESEARCH (2008)
Quantitative atlas of membrane transporter proteins:: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria
Junichi Kamiie et al.
PHARMACEUTICAL RESEARCH (2008)
Modulation of P-glycoprotein at the blood-brain barrier: Opportunities to improve central nervous system pharmacotherapy
David S. Miller et al.
PHARMACOLOGICAL REVIEWS (2008)
Role of brain inflammation in epileptogenesis
Jieun Choi et al.
YONSEI MEDICAL JOURNAL (2008)
Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice
Martina Hubensack et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2008)
The role of efflux and uptake transporters in N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, Lapatinib) disposition and drug interactions
Joseph W. Polli et al.
DRUG METABOLISM AND DISPOSITION (2008)
Thyroxine (T4) transfer from CSF to choroid plexus and ventricular brain regions in rabbit:: Contributory role of P-glycoprotein and organic anion transporting polypeptides
Nouhad A. Kassem et al.
BRAIN RESEARCH (2007)
An international case-control study of interleukin-4Rα, interieukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk
Judith A. Schwartzbaum et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2007)
Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats:: evidence for the involvement of nuclear factor-κb, a nitrosative stress-sensitive transcription factor, in the regulation
Han-Joo Maeng et al.
DRUG METABOLISM AND DISPOSITION (2007)
P-glycoprotein and breast cancer resistance protein: Two dominant transporters working together in limiting the brain penetration of topotecan
Nienke A. de Vries et al.
CLINICAL CANCER RESEARCH (2007)
Application of the ELISPOT method for comparative analysis of interleukin (IL)-6 and IL-10 secretion in peripheral blood of patients with astroglial tumors
Vassilis Samaras et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)
MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer's amyloid-β peptides -: Implications for the mechanisms of Aβ clearance at the blood-brain barrier
Diana Kuhnke et al.
BRAIN PATHOLOGY (2007)
Oxycodone induces overexpression of p-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats
Hazem E. Hassan et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2007)
A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network
Gregory D. Amoutzias et al.
BMC SYSTEMS BIOLOGY (2007)
MicroRNA gets down to business
George S. Mack
NATURE BIOTECHNOLOGY (2007)
Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activity
Junkang Xu et al.
CANCER RESEARCH (2007)
Phosphatase and tensin homologue deficiency in giloblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir
Zibin Jiang et al.
CANCER RESEARCH (2007)
Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors
Denis A. Evseenko et al.
DRUG METABOLISM AND DISPOSITION (2007)
Tumour necrosis factor-α (TNF-α) increases nuclear factor κB (NFκB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells
D. C. Fitzgerald et al.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2007)
Tumor necrosis factor α and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier
Bjorn Bauer et al.
MOLECULAR PHARMACOLOGY (2007)
Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells
Anthony Pilorget et al.
JOURNAL OF NEUROCHEMISTRY (2007)
ABCC10, ABCC11, and ABCC12
Gary D. Kruh et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Inhibition of MDR1 expression with altritol-modified siRNAs
Michael Fisher et al.
NUCLEIC ACIDS RESEARCH (2007)
A silent polymorphism in the MDR1 gene changes substrate specificity
Chava Kimchi-Sarfaty et al.
SCIENCE (2007)
Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor
Elizabeth Fox et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2007)
Opinion - How many drug targets are there?
John P. Overington et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats
P. Dazert et al.
NEUROSCIENCE (2006)
Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter
R. Clark et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Introduction to NF-κB:: players, pathways, perspectives
T. D. Gilmore
ONCOGENE (2006)
Human multidrug resistance ABCB and ABCG transporters:: Participation in a chemoimmunity defense system
Balazs Sarkadi et al.
PHYSIOLOGICAL REVIEWS (2006)
In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation
Bjorn Bauer et al.
MOLECULAR PHARMACOLOGY (2006)
Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier
Edna F. Choo et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy
Tunde Szatmari et al.
CANCER SCIENCE (2006)
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats
EA van Vliet et al.
EPILEPSIA (2006)
Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia
A Spudich et al.
NATURE NEUROSCIENCE (2006)
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
JM Tang et al.
LUNG CANCER (2006)
Rapid modulation of p-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-α and lipopolysaccharide
AMS Hartz et al.
MOLECULAR PHARMACOLOGY (2006)
Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase
J Zhou et al.
CANCER RESEARCH (2006)
Chronotherapeutic dose schedule of phenytoin and carbamazepine in epileptic patients
Radha Yegnanarayan et al.
CHRONOBIOLOGY INTERNATIONAL (2006)
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
IK Mellinghoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
LPS induces CD40 gene expression through the activation of NF-κB and STAT-1α in macrophages and microglia
HW Qin et al.
BLOOD (2005)
Drug delivery across the blood-brain barrier
AMS Hartz et al.
CURRENT NANOSCIENCE (2005)
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model
JR Cirrito et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats
EA van Vliet et al.
EPILEPSIA (2005)
Endothelial/pericyte interactions
A Armulik et al.
CIRCULATION RESEARCH (2005)
Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma
L Pusztai et al.
CANCER (2005)
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
ZB Chen et al.
NATURE (2005)
Regulation of hepatic transporters by xenobiotic receptors
CD Klaassen et al.
CURRENT DRUG METABOLISM (2005)
Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells
T Takada et al.
DRUG METABOLISM AND DISPOSITION (2005)
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver
JM Maher et al.
DRUG METABOLISM AND DISPOSITION (2005)
Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus
P Iannetti et al.
EPILEPSIA (2005)
Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation
I Ifergan et al.
MOLECULAR PHARMACOLOGY (2005)
MGMT gene silencing and benefit from temozolomide in glioblastoma
ME Hegi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Induction of phase I, II and III drug metabolism/transport by xenobiotics
CJ Xu et al.
ARCHIVES OF PHARMACAL RESEARCH (2005)
Nitric oxide mediates increased P-glycoprotein activity in interferon-γ-stimulated human intestinal cells
SG Dixit et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease
Y Ohyagi et al.
FASEB JOURNAL (2005)
Three-dimensional structure of P-glycoprotein - The transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state
MF Rosenberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy
J Walker et al.
EUROPEAN JOURNAL OF CANCER (2004)
Convection-enhanced delivery of paclitaxel for the treatment of recurrent malignant glioma: a Phase I/II clinical study
Z Lidar et al.
JOURNAL OF NEUROSURGERY (2004)
Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene
PLR Ee et al.
CANCER RESEARCH (2004)
Expression of androgen receptor coregulators in prostate cancer
MJ Linja et al.
CLINICAL CANCER RESEARCH (2004)
The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice
EM Kemper et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2004)
MicroRNAs: Genomics, biogenesis, mechanism, and function
DP Bartel
CELL (2004)
Variable modulation of opioid brain uptake by P-glycoprotein in mice
C Dagenais et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1
AMS Hartz et al.
MOLECULAR PHARMACOLOGY (2004)
Effect of λ-carrageenan-induced inflammatory pain on brain uptake of codeine and antinociception
VS Hau et al.
BRAIN RESEARCH (2004)
LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms
R Deane et al.
NEURON (2004)
Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[ 2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey
KW Ward et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism
HJ Zhu et al.
LIFE SCIENCES (2004)
The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes
XL Song et al.
DRUG METABOLISM AND DISPOSITION (2004)
Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression - A role for BCRP in cellular folate homeostasis
I Ifergan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Intracellular Aβ42 activates p53 promoter:: a pathway to neurodegeneration in Alzheimer's disease
Y Ohyagi et al.
FASEB JOURNAL (2004)
Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions
BR Balsara et al.
CARCINOGENESIS (2004)
Modulation of multidrug-resistance-associated P-glycoprotein in human U-87 MG and HUV-ECC cells with antisense oligodeoxynucleotides to MDR1 mRNA
M Rittierodt et al.
PATHOBIOLOGY (2004)
Transforming growth factor-β1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells
S Dohgu et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2004)
The Role of P-glycoprotein in Cerebral Amyloid Angiopathy; Implications for the Early Pathogenesis of Alzheimer's Disease
Silke Vogelgesang et al.
CURRENT ALZHEIMER RESEARCH (2004)
Two-photon imaging of capillary blood flow in olfactory bulb glomeruli
E Chaigneau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Transcriptional regulation of ABC drug transporters
KW Scotto
ONCOGENE (2003)
Akt signaling regulates side population cell phenotype via Bcrp1 translocation
M Mogi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Expression and functional characterization of ABCG2 in brain endothelial cells and vessels
WD Zhang et al.
FASEB JOURNAL (2003)
ABC transporters and drug resistance in parasitic protozoa
A Klokouzas et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2003)
Breast cancer resistance protein exports sulfated estrogens but not free estrogens
Y Imai et al.
MOLECULAR PHARMACOLOGY (2003)
Inflammatory processes in Alzheimer's disease
EG McGeer et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2003)
ABCG2 transports sulfated conjugates of steroids and xenobiotics
M Suzuki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin
A Roulet et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the Oocytes of Xenopus laevis
T Nakanishi et al.
MOLECULAR PHARMACOLOGY (2003)
Relationship between expression of multiple drug resistance proteins and p53 tumor suppressor gene proteins in human brain astrocytes
M Marroni et al.
NEUROSCIENCE (2003)
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine
CP Zamber et al.
PHARMACOGENETICS (2003)
Localisation of breast cancer resistance protein in microvessel endothelium of human brain
HC Cooray et al.
NEUROREPORT (2002)
The LSGGQ motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing Walker A sequence
TW Loo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
S Fellner et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Deposition of Alzheimer's β-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
S Vogelgesang et al.
PHARMACOGENETICS (2002)
Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF
C Monville et al.
BMC CELL BIOLOGY (2002)
GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats
JE Edwards et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
A new multidrug resistance protein at the blood-brain barrier
T Eisenblätter et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Inducible nitric oxide synthase and argininosuccinate synthetase:: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with β-amyloid 1-42 in vitro
J Haas et al.
NEUROSCIENCE LETTERS (2002)
Cancer chemoresistance: the relationship between p53 and multidrug transporters
JA Bush et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization
K Kage et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Vascular genomics of the human brain
EV Shusta et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)
Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes
S Spiegl-Kreinecker et al.
JOURNAL OF NEURO-ONCOLOGY (2002)
Estrone and 17 beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance
Y Imai et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2002)
P-glycoprotein expression in rat brain endothelial cells: evidence for regulation by transient oxidative stress
RA Felix et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation
A El-Osta et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy
SM Dombrowski et al.
EPILEPSIA (2001)
Nuclear receptor minireview series
JM Olefsky
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Brain drug targeting and gene technologies
WM Pardridge
JAPANESE JOURNAL OF PHARMACOLOGY (2001)
Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsants
DS Cox et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2001)
Receptor tyrosine kinase signalling as a target for cancer intervention strategies
E Zwick et al.
ENDOCRINE-RELATED CANCER (2001)
Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits
K Hynynen et al.
RADIOLOGY (2001)
The human ATP-binding cassette (ABC) transporter superfamily
M Dean et al.
GENOME RESEARCH (2001)
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
TW Synold et al.
NATURE MEDICINE (2001)
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
M Hellström et al.
JOURNAL OF CELL BIOLOGY (2001)
Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells
BB Fredholm et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice
S Cisternino et al.
PHARMACEUTICAL RESEARCH (2001)
β-Amyloid efflux mediated by p-glycoprotein
FC Lam et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Regional differences in mechanisms of cerebral circulatory response to neuronal activation
J Gotoh et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)
Blood-brain barrier genomics
JY Li et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)
Morning-evening administration time differences in digoxin kinetics in healthy young subjects
K Erol et al.
CHRONOBIOLOGY INTERNATIONAL (2001)
Drug resistance-associated factors in primary and secondary glioblastomas and their precursor tumors
DS Tews et al.
JOURNAL OF NEURO-ONCOLOGY (2000)
Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
M Shibata et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
The protein tyrosine kinase family of the human genome
DR Robinson et al.
ONCOGENE (2000)
Cell signaling by receptor tyrosine kinases
J Schlessinger
CELL (2000)
Role of oxidants in NF-κB activation and TNF-α gene transcription induced by hypoxia and endotoxin
NS Chandel et al.
JOURNAL OF IMMUNOLOGY (2000)
P-glycoprotein inhibitor valspodar (PSC 833) increases the intracellular concentrations of daunorubicin in vivo in patients with p-glycoprotein-positive acute myeloid leukemia
U Tidefelt et al.
JOURNAL OF CLINICAL ONCOLOGY (2000)
Inflammation and Alzheimer's disease
H Akiyama et al.
NEUROBIOLOGY OF AGING (2000)
The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane
E Rocchi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Early identification of refractory epilepsy.
P Kwan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex
K Niwa et al.
JOURNAL OF NEUROSCIENCE (2000)
Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia
SL Yates et al.
JOURNAL OF NEUROCHEMISTRY (2000)
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