4.7 Article

Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Inhibition of Drp1-dependent mitochondrial fission by natural compounds as a therapeutic strategy for organ injuries

Sohrab Rahmani et al.

Summary: Mitochondria are dynamic organelles that undergo fission and fusion processes to regulate their integrity and bioenergetics. Excessive mitochondrial fission can lead to structural changes, dysfunction, and cell damage. Accumulating evidence shows that mitochondrial dynamics play a role in neurodegenerative and cardiovascular diseases, as well as other diseases.

PHARMACOLOGICAL RESEARCH (2023)

Review Oncology

The function of natural compounds in important anticancer mechanisms

Yang Nan et al.

Summary: The existence of malignant tumors poses a threat to human life, health, and safety. Natural compounds derived from traditional Chinese medicine have shown significant anti-tumor activities and positive effects on various types of cancer, including breast cancer, liver cancer, lung cancer, gastric cancer, and rectal cancer. This study investigates the effects of natural compounds on cancer through four important pathways closely related to the disease, including cell death and immunogenic cell death, immune cells in the tumor microenvironment, inflammation and related pathways, and tumor metastasis.

FRONTIERS IN ONCOLOGY (2023)

Article Biochemistry & Molecular Biology

In-Silico molecular screening of natural compounds as a potential therapeutic inhibitor for Methicillin-resistant Staphylococcus aureus inhibition

Palanichamy Nandhini et al.

Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening superbug that is resistant to conventional antibiotics. Through molecular docking studies, natural bioactive compounds such as Luteolin, Kaempferol, Chlorogenic acid, Sinigrin, Zingiberene, 1-Methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohex-1-ene, and Curcumin have been identified as potential ligands for treating MRSA infections due to their good binding energies.

CHEMICO-BIOLOGICAL INTERACTIONS (2023)

Review Oncology

Exosomes as a Source of Biomarkers for Gastrointestinal Cancers

Jingjing Yu et al.

Summary: Exosomes are small extracellular vesicles that carry important information for intercellular communication. They are produced abundantly by tumor cells and carry tumor-specific content, such as DNA, RNA, and proteins, which play significant roles in cancer development and progression. Due to their presence in various biofluids, exosomes can be developed as liquid biopsy tools for early diagnosis, molecular profiling, disease surveillance, and treatment response monitoring. This review focuses on the diagnostic, prognostic, and predictive potential of exosomal biomarkers in colorectal and gastric cancers, and discusses the challenges and limitations of their clinical application.

CANCERS (2023)

Article Oncology

Similarities and Differences in the Protein Composition of Cutaneous Melanoma Cells and Their Exosomes Identified by Mass Spectrometry

Magdalena Surman et al.

Summary: This study used shotgun nanoLC-MS/MS to obtain protein profiles of melanoma cells and exosomes. The results provide a deeper understanding of the role of exosomes in melanoma progression and suggest potential biomarkers for circulating melanoma.

CANCERS (2023)

Article Biochemistry & Molecular Biology

Geraniin targeting CaMKK2 inhibits lipid accumulation in 3T3-L1 adipocytes by suppressing lipogenesis

Ji Li et al.

Summary: Obesity is a global burden linked to severe medical complications. Geraniin, a polyphenolic compound, has shown pharmacological effects in reducing lipid accumulation and obesity. This study investigates the mechanism of geraniin in inhibiting lipid accumulation in adipocytes.

CHEMICO-BIOLOGICAL INTERACTIONS (2023)

Article Biochemistry & Molecular Biology

Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway

Mukesh K. Sriwastva et al.

Summary: Edible mulberry bark-derived nanoparticles (MBELNs) can protect against colitis by activating the AhR-COPS8-mediated anti-inflammatory pathway. These findings suggest that plant-derived nanoparticles may serve as new agents for preventing and treating gut-related inflammatory diseases.

EMBO REPORTS (2022)

Article Gastroenterology & Hepatology

Tumor-derived exosomes induce immunosuppressive macrophages to foster intrahepatic cholangiocarcinoma progression

Chubin Luo et al.

Summary: Macrophages in ICC tumor tissues upregulate PD-L1 expression, suppressing T-cell immunity and correlating with poor survival rates. Exosomal miR-183-5p from ICC cells inhibits PTEN expression in macrophages, leading to elevated AKT phosphorylation and PD-L1 expression, contributing to ICC progression. Plasma exosomal miR-183-5p levels are associated with poor prognosis in ICC patients.

HEPATOLOGY (2022)

Review Biochemistry & Molecular Biology

Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers

Theodora Karamanidou et al.

Summary: This review summarizes the progress in the use of plant-derived extracellular vesicles as therapeutic delivery systems. Despite some controversies, plant-derived EVs show significant potential as nanodelivery systems of natural origin.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Oncology

First-Line Immunotherapy for Non-Small-Cell Lung Cancer

Martin Reck et al.

Summary: The past decade has seen significant progress in the treatment of metastatic non-small-cell lung cancer, with the development of specific antibodies leading to improved survival for many patients. Currently, nearly all mNSCLC patients receive PD-1 or PD-L1 therapy in the first-line setting, except those with targetable oncogenes.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Chemistry, Multidisciplinary

Restoring Oat Nanoparticles Mediated Brain Memory Function of Mice Fed Alcohol by Sorting Inflammatory Dectin-1 Complex Into Microglial Exosomes

Fangyi Xu et al.

Summary: Understanding and controlling the activities of microglia can improve brain health, and oral administration of oat nanoparticles can effectively prevent alcohol-induced brain inflammation.
Article Chemistry, Multidisciplinary

Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress

Wan-jun Zhao et al.

Summary: The study demonstrates that blueberry-derived exosomes-like nanoparticles can ameliorate oxidative stress, improve the pathogenesis of NAFLD, regulate cell apoptosis and lipid metabolism, enhance antioxidant capacity, and may serve as a novel approach for the treatment of NAFLD.

ACTA PHARMACOLOGICA SINICA (2022)

Review Pharmacology & Pharmacy

Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

Rui-Lin Liu et al.

Summary: This review highlights recent advances (2015-2020) in the design and synthesis of contrast agents and the improvement of imaging systems to achieve high-resolution ultrasound-controlled fluorescence (UCF) imaging of deep tissues. The imaging performances of various UCF systems are discussed, and the challenges and prospects are highlighted.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2022)

Review Pharmacology & Pharmacy

Technology insight: Plant-derived vesicles-How far from the clinical biotherapeutics and therapeutic drug carriers?

Minghui Cong et al.

Summary: Plant extracellular vesicles (EVs) and exosome-like nanoparticles (ELNs) have emerged as important mediators of intercellular communication, with potential applications in biological processes regulation, disease prevention and treatment, and drug delivery. This review provides an overview of the development, techniques, biological activities, and clinical potential of plant EVs and ELNs, as well as the challenges and future directions in realizing their clinical transformation.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Article Immunology

Mesenchymal Stem Cells-derived Exosomes Ameliorate Lupus by Inducing M2 Macrophage Polarization and Regulatory T Cell Expansion in MRL/lpr Mice

Wenchang Sun et al.

Summary: This study investigates the role of exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) in systemic lupus erythematosus (SLE). The results show that hUC-MSC-derived exosomes have anti-inflammatory and immunomodulatory effects, alleviating organ injuries in SLE by inducing the polarization of M2 macrophages and regulatory T cells (Tregs). These exosomes may serve as a promising cell-free therapeutic strategy for SLE.

IMMUNOLOGICAL INVESTIGATIONS (2022)

Review Nanoscience & Nanotechnology

Exosomes as Promising Nanostructures in Diabetes Mellitus: From Insulin Sensitivity to Ameliorating Diabetic Complications

Milad Ashrafizadeh et al.

Summary: Exosomes have great potential in the treatment of diabetes mellitus, as they can regulate glucose and lipid metabolism, ameliorate apoptosis and endoplasmic reticulum stress in beta cells, and influence insulin resistance/sensitivity.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

Article Anatomy & Morphology

Beta vulgaris juice contains biologically active exosome-like nanoparticles

Elahe Mahdipour

Summary: Plant-derived exosome-like nanoparticles from Beta vulgaris extract (BEX) were characterized and found to possess antioxidative and angiogenic properties. BEX treatment promoted angiogenesis and inhibited migration ability of fibroblasts, while also exhibiting antiaging and anti-scar capacities. These findings suggest potential cosmetic and therapeutic applications for Beta vulgaris.

TISSUE & CELL (2022)

Review Pharmacology & Pharmacy

Plant-derived exosome-like nanoparticles and their therapeutic activities

Jisu Kim et al.

Summary: Nanotechnologies have been successfully applied in the treatment of various diseases. Plant-derived exosome-like nanoparticles (PENs) are expected to be effective therapeutic modalities, minimizing cytotoxicity to healthy tissues while targeting tumors with specific endocytosis mechanisms. This review summarizes the features and bioactivities of PENs extracted from grape, grapefruit, ginger, lemon, and broccoli, and discusses their applications as therapeutics and nanocarriers.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Article Cardiac & Cardiovascular Systems

Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction

Wen-Wen Cui et al.

Summary: This study found that Momordica.charantia-derived EVs-like nanovesicles (MCELNs) can protect cardiomyocytes from radiation-induced damage and have antioxidant effects. MCELNs promote cell proliferation, alleviate cell apoptosis and DNA damage, and protect mitochondrial function. Moreover, MCELNs can restore the phosphorylation levels of ROS-related proteins and mitigate myocardial injury and fibrosis caused by thoracic radiation.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Article Medicine, Research & Experimental

Extracellular vesicles of cannabis with high CBD content induce anticancer signaling in human hepatocellular carcinoma

Tahereh Tajik et al.

Summary: Plant-derived extracellular vesicles (EVs) have gained attention in recent years due to their proven therapeutic properties. In this study, EVs were isolated from two different chemotypes of cannabis and classified as high-CBD and low-CBD EVs. These EVs exhibited different cytotoxicity and anticancer effects. The findings suggest that CDEVs could be an ideal natural vehicle for delivering bioactive phytocannabinoids and a promising strategy in cancer management.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Oncology

Tumor-derived exosomes in the cancer immune microenvironment and cancer immunotherapy

Qiushi Tang et al.

Summary: Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.

CANCER LETTERS (2022)

Review Oncology

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Mahshid Deldar Abad Paskeh et al.

Summary: This review discusses the role of exosomes in cancer progression, therapy, and regulation of the tumor microenvironment. The study found that exosomes can influence cancer cell proliferation and migration rates by modulating components of the tumor microenvironment. Depending on their cargo, exosomes can promote or suppress tumor cell progression and enhance or reduce the response to radiotherapy and chemotherapy. Additionally, exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by transferring RNA and modulating molecular signaling pathways. Moreover, exosomes can serve as carriers of anti-tumor agents and genetic tools to control cancer progression. Finally, exosomes are valuable diagnostic and prognostic tools in the treatment of cancer patients.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

BMSCs overexpressed ISL1 reduces the apoptosis of islet cells through ANLN carrying exosome, INHBA, and caffeine

Ying Wang et al.

Summary: Early apoptosis is a major factor affecting the efficacy of islet transplantation, and the combined transplantation of islet cells and bone marrow mesenchymal stem cells can improve the survival rate. ISL1 promotes angiogenesis of grafted islets and paracrine function of BMSCs, reducing apoptosis and improving survival rate by regulating the expression of ANLN and INHBA.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Review Oncology

Advances in Exosomes as Diagnostic and Therapeutic Biomarkers for Gynaecological Malignancies

Mengdan Miao et al.

Summary: Exosomes, as an important form of intercellular communication, show potential advantages in the diagnosis, treatment, and prognosis of gynaecological malignancies.

CANCERS (2022)

Article Engineering, Biomedical

Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy

Xiaoxue Xie et al.

Summary: This study reported a tumor acidity-responsive nanovaccine that can remodel the immunosuppressive tumor microenvironment, enhance recruitment of tumor infiltrating lymphocytes, improve antigen presentation and drug transportation efficiency, leading to tumor growth inhibition and long-term tumor inhibition.

BIOACTIVE MATERIALS (2022)

Review Biochemistry & Molecular Biology

Colon cancer and colorectal cancer: Prevention and treatment by potential natural products

Md Rezaul Islam et al.

Summary: Colon cancer is the world's second leading cause of cancer-related deaths, and its death rates have increased due to modern lifestyle. Natural compounds in medicinal plants show potential in combating colon cancer through activation of signaling pathways.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

Article Medicine, Research & Experimental

Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis

Caifang Gao et al.

Summary: Turmeric-derived nanovesicles (TNVs) showed promising anti-inflammatory effects by restoring damaged intestinal barrier, regulating gut microbiota, and reshaping macrophage phenotype.

THERANOSTICS (2022)

Review Chemistry, Medicinal

Extracellular Vesicles in Skin Wound Healing

Deimante Narauskaite et al.

Summary: Extracellular vesicles (EVs) play a crucial role in wound healing and potential therapeutic interventions. In addition to their natural healing capacity, EVs can be engineered to carry specific cargo for targeted pharmaceutical purposes, making them a promising treatment modality.

PHARMACEUTICALS (2021)

Review Pharmacology & Pharmacy

The therapeutic triad of extracellular vesicles: As drug targets, as drugs, and as drug carriers

Milad Moloudizargari et al.

Summary: The passage discusses the three main therapeutic uses of extracellular vesicles (EVs): as drug targets, as drugs themselves, and as drug carriers. It emphasizes the need for a comprehensive understanding of EVs' biology and function for their effective therapeutic applications, while exploring various strategies for their use in therapy.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Engineering, Biomedical

High-quality milk exosomes as oral drug delivery system

Jie Zhong et al.

Summary: Exosomes are nano-sized extracellular vesicles secreted by mammalian cells, including milk exosomes which have the potential to cross biological barriers and serve as promising drug delivery tools for oral administration.

BIOMATERIALS (2021)

Review Biotechnology & Applied Microbiology

Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms

Haseeb Anwar Dad et al.

Summary: Plant exosome-like nanovesicles, rich in bioactive components, hold great potential in the fields of biotreatment and drug delivery, exhibiting immunomodulatory, antitumor, regenerative, and anti-inflammatory effects. Their physicochemical traits make them promising candidates for next-generation therapeutic and drug delivery nanoplatforms.

MOLECULAR THERAPY (2021)

Review Biochemistry & Molecular Biology

Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities

Ying Luo et al.

Summary: Antimicrobial peptides (AMPs) are considered a new generation of antibiotics with not only antimicrobial activity but also antibiofilm, immune-regulatory, and other activities. Research on the mechanism of action of AMPs can aid in their modification and development, with many studies focusing on this area. AMPs exhibit a dual mechanism of action and possess antifibroblast and anti-inflammatory properties, making them a promising therapeutic prospect.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biotechnology & Applied Microbiology

Roles of Bile-Derived Exosomes in Hepatobiliary Disease

Yuan Yao et al.

Summary: This review provides a comprehensive summary of bile-derived exosomes, focusing on their isolation methods and the roles of exosomal noncoding RNAs in physiological and disease states. It also discusses the potential clinical applications of bile-derived exosomes.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells

Francesca Perut et al.

Summary: EPDENs isolated from strawberries have been shown to have potential health-promoting activities, including preventing oxidative stress in human mesenchymal stromal cells. The presence of vitamin C in the EPDEN membrane may contribute to this effect, along with the small RNAs and miRNAs found in the cargo. These findings suggest that Fragaria-derived EPDENs may serve as nanoshuttles in food with bioactive properties.

BIOMOLECULES (2021)

Review Oncology

Exosome-based liquid biopsies in cancer: opportunities and challenges

W. Yu et al.

Summary: Liquid biopsy in cancer research has seen significant progress, with efforts focused on utilizing circulating tumor cells, circulating tumor DNA, and extracellular vesicles like exosomes. Exosomes, as part of the intercellular communication system, carry tumor-derived materials and can serve as stable biomarkers for early detection and monitoring of cancer.

ANNALS OF ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Shi-Wei Chen et al.

Summary: In human non-small cell lung cancer (NSCLC) tissues, high expression levels of circUSP7 are associated with poor clinical prognosis and dysfunction of CD8(+) T cells. CircUSP7 found in NSCLC patient plasma is mainly secreted by NSCLC cells via exosomes, inhibiting CD8(+) T cell function by upregulating SHP2 expression. Additionally, circUSP7 may contribute to resistance to anti-PD1 immunotherapy in NSCLC patients.

MOLECULAR CANCER (2021)

Review Immunology

NLRP3 inflammasome in cancer and metabolic diseases

Bhesh Raj Sharma et al.

Summary: The NLRP3 inflammasome plays diverse roles in cancer and metabolic diseases, being involved in the release of inflammatory cytokines and inflammatory cell death upon activation. While inflammatory cytokines contribute to chronic inflammation and disease pathogenesis, fine tuning NLRP3 activity is crucial for maintaining cellular health.

NATURE IMMUNOLOGY (2021)

Article Cell Biology

Exosomes in ovarian cancer ascites promote epithelial-mesenchymal transition of ovarian cancer cells by delivery of miR-6780b-5p

Jing Cai et al.

Summary: Poor prognosis of ovarian cancer is mainly due to metastasis, with ascites-derived exosomes playing a role in promoting metastasis through epithelial-mesenchymal transition. The key microRNA miR-6780b-5p in ADEs facilitates cancer metastasis by promoting EMT in ovarian cancer cells, indicating a potential mechanism for ovarian cancer progression.

CELL DEATH & DISEASE (2021)

Review Cell Biology

Current landscape of tumor-derived exosomal ncRNAs in glioma progression, detection, and drug resistance

Xiao He et al.

Summary: Glioma is the most common and fatal tumor of the central nervous system in humans, with a highly complex tumor microenvironment. Exosomes play a crucial role in regulating this environment by carrying a wide range of non-coding RNAs.

CELL DEATH & DISEASE (2021)

Article Engineering, Biomedical

Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells

Jae Young You et al.

Summary: Studies on plant-derived exosome-like nanovesicles from cabbage and red cabbage have shown promising biological functions and potential applications, demonstrating their wide utilization as novel therapeutic biomaterials.

BIOACTIVE MATERIALS (2021)

Letter Biochemistry & Molecular Biology

Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma

Lanyun Zhou et al.

Summary: Plasma-derived exosomal miR-15a-5p is identified as a promising and effective diagnostic biomarker for early detection of endometrial cancer, showing close connection with clinical manifestations in EC patients.

MOLECULAR CANCER (2021)

Article Biotechnology & Applied Microbiology

Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12

Yun Teng et al.

Summary: The study found that exosomes released from lung epithelial cells exposed to SARS-CoV-2 led to inflamed lung tissue in mice. These exosomes were taken up by lung macrophages, inducing lung inflammation and ultimately causing apoptosis of lung epithelial cells. Ginger exosome-like nanoparticles (GELNs) containing specific miRNA played a crucial role in inhibiting inflammation.

MOLECULAR THERAPY (2021)

Review Biochemistry & Molecular Biology

Extracellular Vesicles from Plants: Current Knowledge and Open Questions

Ornella Urzi et al.

Summary: The scientific interest in natural substances and extracellular vesicles (EVs) released by animal and plant cells is longstanding. Currently, research on plant-derived extracellular vesicles (PDEVs) in terms of content isolation, biological properties, and drug delivery systems is gaining momentum.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, Research & Experimental

Single-cell analysis of a tumor-derived exosome signature correlates with prognosis and immunotherapy response

Jiani Wu et al.

Summary: The study established a tumor-derived exosome signature named TEXscore to predict overall survival in multiple cancer types and in patients undergoing immune checkpoint blockade therapies. TEXscore was associated with disease progression and poor clinical outcomes, serving as a reliable biomarker to distinguish cancer from non-cancer sources. TEXscore showed great potential in predicting immunotherapy response in a variety of cancers.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine

Mangesh D. Hade et al.

Summary: Exosomes are extracellular vesicles secreted by almost all cell types to aid in various cellular functions, including intercellular communication and immune signaling. They carry a multitude of signaling moieties, making them potential candidates for tissue engineering and regenerative medicine. The review highlights the emerging roles and potential applications of exosomes in regenerative medicine, particularly in brain injuries, cardiovascular disease, and COVID-19.
Article Pharmacology & Pharmacy

Antioxidative Effects of Carrot-Derived Nanovesicles in Cardiomyoblast and Neuroblastoma Cells

Do Kyung Kim et al.

Summary: The study isolated Carex nanovesicles from carrots as a novel biomaterial with antioxidative function for cardiomyoblasts and neuroblastoma cells. Carex exhibited low cytotoxicity and significantly inhibited ROS generation and apoptosis, showing potential as a drug candidate for myocardial infarction and Parkinson's disease treatment.

PHARMACEUTICS (2021)

Article Biochemistry & Molecular Biology

Immunostimulatory Potential of Extracellular Vesicles Isolated from an Edible Plant, Petasites japonicus, via the Induction of Murine Dendritic Cell Maturation

Jeong Moo Han et al.

Summary: Plant-derived EVs, specifically Petasites japonicus-derived EVs, have been found to induce the maturation of dendritic cells (DCs) and exhibit immunomodulatory effects through upregulation of surface molecules and cytokines, as well as antigen-presenting ability. This maturation process is dependent on the activation of MAPK and NF-kappa B signal pathways. Furthermore, PJ-EV-treated DCs have shown strong potential in inducing the proliferation and differentiation of T cells towards Th1-type and cytotoxic T cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Grapefruit-derived extracellular vesicles as a promising cell-free therapeutic tool for wound healing

Yagiz Savci et al.

Summary: Plant-derived extracellular vesicles (GEVs) show potential in promoting cell viability, migration, and tube formation capabilities; GEVs from grapefruits can be used as plant-derived wound healing agents, opening up new avenues for biotechnological wound healing.

FOOD & FUNCTION (2021)

Review Pharmacology & Pharmacy

The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of In Vivo Studies

Frances R. Henshaw et al.

Summary: Through the study, it was found that CBD, CBG, and CBD+THC combination have anti-inflammatory effects in vivo, whereas THC alone does not reduce pro-inflammatory or increase anti-inflammatory cytokines. This information could be used to guide human clinical trials of cannabinoids, focusing on CBD and CBG to reduce inflammation across a range of pathophysiological processes.

CANNABIS AND CANNABINOID RESEARCH (2021)

Review Biotechnology & Applied Microbiology

Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Article Biotechnology & Applied Microbiology

Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6

Bobin Mi et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

An efficient method to isolate lemon derived extracellular vesicles for gastric cancer therapy

Meng Yang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Review Nanoscience & Nanotechnology

Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development

Victor C. Kok et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Review Biochemistry & Molecular Biology

Emerging role of bacterial extracellular vesicles in cancer

Antonios Chronopoulos et al.

ONCOGENE (2020)

Article Medicine, Research & Experimental

Use of Nanovesicles from Orange Juice to Reverse Diet-Induced Gut Modifications in Diet-Induced Obese Mice

Emmanuelle Berger et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Review Immunology

Targeting IL-1β in the Treatment of Atherosclerosis

Wuqian Mai et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

The role of IL-22 in intestinal health and disease

Mary E. Keir et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Oncology

Exosomes increased angiogenesis in papillary thyroid cancer microenvironment

Feng Wu et al.

ENDOCRINE-RELATED CANCER (2019)

Review Medicine, Research & Experimental

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Sofie Voet et al.

EMBO MOLECULAR MEDICINE (2019)

Review Biochemistry & Molecular Biology

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Ladan Mashouri et al.

MOLECULAR CANCER (2019)

Review Biochemistry & Molecular Biology

The microbiota and microbiome in pancreatic cancer: more influential than expected

Miao-Yan Wei et al.

MOLECULAR CANCER (2019)

Review Biochemistry & Molecular Biology

Neddylation: a novel modulator of the tumor microenvironment

Lisha Zhou et al.

MOLECULAR CANCER (2019)

Article Medicine, Research & Experimental

Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation

Xingyi Chen et al.

MOLECULAR PHARMACEUTICS (2019)

Review Immunology

Targeting Tumor-Associated Macrophages in Cancer

Paulina Pathria et al.

TRENDS IN IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Exosomes

D. Michiel Pegtel et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

Review Biochemistry & Molecular Biology

The role of exosomal PD-L1 in tumor progression and immunotherapy

Feiting Xie et al.

MOLECULAR CANCER (2019)

Article Oncology

Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth

Meng Cao et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Article Biochemistry & Molecular Biology

Membrane Transporters in Citrus clementina Fruit Juice-Derived Nanovesicles

Christopher Stanly et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Agriculture, Dairy & Animal Science

Milk-Derived Exosomes and Metabolic Regulation

Janos Zempleni et al.

ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 7 (2019)

Review Cell Biology

Tumor-associated macrophages: an accomplice in solid tumor progression

Yibing Chen et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

Review Cell Biology

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

Zahra Hoseini et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Biotechnology & Applied Microbiology

The role of exosomes derived from cerebrospinal fluid of spinal cord injury in neuron proliferation in vitro

Fan-Long Kong et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

Review Biotechnology & Applied Microbiology

Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds

Ammad Ahmad Farooqi et al.

BIOTECHNOLOGY ADVANCES (2018)

Article Oncology

Proteomics study of serum exosomes from papillary thyroid cancer patients

Dan Luo et al.

ENDOCRINE-RELATED CANCER (2018)

Review Immunology

Inflammation in CNS neurodegenerative diseases

Jodie Stephenson et al.

IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Salivary Exosomes: Emerging Roles in Systemic Disease

Yineng Han et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Review Biotechnology & Applied Microbiology

Targeting the NLRP3 inflammasome in inflammatory diseases

Matthew S. J. Mangan et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Oncology

The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer

Mona Alharbi et al.

ENDOCRINE-RELATED CANCER (2018)

Article Microbiology

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

Yun Teng et al.

CELL HOST & MICROBE (2018)

Review Biochemistry & Molecular Biology

The Methods of Choice for Extracellular Vesicles (EVs) Characterization

Rafal Szatanek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Immunology

Cytokine networks in neuroinflammation

Burkhard Becher et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines

Eugene Y. Kim et al.

CYTOKINE (2017)

Article Oncology

CD103 and Intratumoral Immune Response in Breast Cancer

Zhi-Qiang Wang et al.

CLINICAL CANCER RESEARCH (2016)

Review Chemistry, Multidisciplinary

DLS and zeta potential - What they are and what they are not?

Sourav Bhattacharjee

JOURNAL OF CONTROLLED RELEASE (2016)

Article Multidisciplinary Sciences

Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome

Simone Cavadini et al.

NATURE (2016)

Article Oncology

Plasma exosome microRNAs are indicative of breast cancer

Bethany N. Hannafon et al.

BREAST CANCER RESEARCH (2016)

Review Immunology

Interleukin-22: Immunobiology and Pathology

Jarrod A. Dudakov et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

Article Cardiac & Cardiovascular Systems

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

Jose M. Vicencio et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Article Cell Biology

Ginger-derived nanoparticles protect against alcohol-induced liver damage

Xiaoying Zhuang et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Review Immunology

Innate and adaptive immunity in inflammatory bowel disease

Alessandra Geremia et al.

AUTOIMMUNITY REVIEWS (2014)

Article Food Science & Technology

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles

Jingyao Mu et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2014)

Article Biotechnology & Applied Microbiology

Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit

Baomei Wang et al.

MOLECULAR THERAPY (2014)

Article Cell Biology

IL-6 in Inflammation, Immunity, and Disease

Toshio Tanaka et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Review Immunology

Cytokines in inflammatory bowel disease

Markus F. Neurath

NATURE REVIEWS IMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

Songwen Ju et al.

MOLECULAR THERAPY (2013)

Review Immunology

The regulation of IL-10 production by immune cells

Margarida Saraiva et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Article Urology & Nephrology

Large-Scale Proteomics and Phosphoproteomics of Urinary Exosomes

Patricia A. Gonzales et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Biochemistry & Molecular Biology

Do Plant Cells Secrete Exosomes Derived from Multivesicular Bodies?

Qianli An et al.

PLANT SIGNALING & BEHAVIOR (2007)

Review Biochemistry & Molecular Biology

Insulin resistance in adipose tissue:: direct and indirect effects of tumor necrosis factor-α

H Ruan et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2003)

Article Biochemistry & Molecular Biology

Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

TS Lee et al.

NATURE MEDICINE (2002)