Chinese herbal compound Huangqin Qingrechubi capsule reduces lipid metabolism disorder and inflammatory response in gouty arthritis via the LncRNA H19/APN/PI3K/AKT cascade

Article Integrative & Complementary Medicine

3β,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from Cyclocarya paliurus Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy

Dongxiao Lou et al.

Summary: The study showed that compound 2 from Cyclocarya paliurus can effectively improve NLRP3 inflammasome-mediated gout through PI3K-AKT-mTOR-dependent autophagy, suggesting its potential as an agent against gout.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Genetics & Heredity

MiR-421 promotes lipid metabolism by targeting PTEN via activating PI3K/AKT/mTOR pathway in non-small cell lung cancer

Yong-Jie Xu et al.

Summary: MiR-421 promotes lipid metabolism through targeting PTEN via activation of the PI3K/AKT/mTOR pathway in NSCLC. This study provides a deeper insight into the prognostic strategies for lung cancer by understanding the specific mechanism of miR-421 in lipid metabolism.

EPIGENOMICS (2022)

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Article Multidisciplinary Sciences

Adiponectin is negatively associated with disease activity and Sharp score in treatment-naive Han Chinese rheumatoid arthritis patients

Xixi Chen et al.

Summary: This study investigated the relationship between serum adiponectin level and disease activity in treatment-naive Han Chinese RA patients, finding a negative correlation with DAS28(ESR) and the Sharp score. These results suggest that adiponectin may be useful for assessing disease activity and radiographic progression of RA.

SCIENTIFIC REPORTS (2022)

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Article Immunology

H19 is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting miR-2-3p

Yan-Yan Xue et al.

Summary: This study investigated the regulatory mechanism of H19 on acute gouty arthritis (AGA) and found that H19 aggravated inflammation by negatively targeting miR-22-3p. This discovery provides a new therapeutic target for the treatment of AGA.

IMMUNOLOGIC RESEARCH (2022)

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Article Nutrition & Dietetics

Neohesperidin Dihydrochalcone and Neohesperidin Dihydrochalcone-O-Glycoside Attenuate Subcutaneous Fat and Lipid Accumulation by Regulating PI3K/AKT/mTOR Pathway In Vivo and In Vitro

Minseo Kwon et al.

Summary: Neohesperidin dihydrochalcone (NHDC) and its derivative NHDC-O-glycoside (GNHDC) can inhibit obesity and lipid accumulation through regulating multiple pathways.

NUTRIENTS (2022)

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Article Rheumatology

LncRNA-H19 silencing suppresses synoviocytes proliferation and attenuates collagen-induced arthritis progression by modulating miR-124a

Xiaohong Fu et al.

Summary: lncRNA-H19 plays a crucial role in the proliferation of fibroblast-like synoviocytes (FLS) by competitively binding to miR-124a and modulating the expression of CDK2 and MCP-1. Targeting the lncRNA-H19-miR-124a-CDK2/MCP-1 axis may have therapeutic potential in rheumatoid arthritis treatment through the inhibition of the signaling pathway.

RHEUMATOLOGY (2021)

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Article Oncology

The double-edged sword of H19 lncRNA: Insights into cancer therapy

Yun Wei Shermane Lim et al.

Summary: H19 long non-coding RNA has dual roles in cancer, acting as both an oncogene and a suppressor gene in tumor development. It plays a crucial role in cancer therapy through various mechanisms, including its applications in recombinant vectors, chemoresistance, epigenetic regulation, alteration of tumor microenvironment, and cancer immunotherapy, as well as its relationship with the tumor suppressor gene p53.

CANCER LETTERS (2021)

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Article Food Science & Technology

Computational pharmacology and bioinformatics to explore the potential mechanism of Schisandra against atherosclerosis

Hong Duan et al.

Summary: This study applies network pharmacology to investigate the potential mechanisms of Schisandra against atherosclerosis. Through drug-disease target exploration and construction of a component/pathway-target interaction network, key regulatory factors of Schisandra were identified.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Rheumatology

The inflammatory role of silent urate crystal deposition in intercritical gout

Cesar Diaz-Torne et al.

Summary: The study showed elevated levels of certain pro-inflammatory cytokines and metabolic proteins in intercritical gout patients. These levels were associated with estimated monosodium urate crystal deposition and cardiovascular risk factors.

RHEUMATOLOGY (2021)

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Article Pharmacology & Pharmacy

Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release

Kefeng Zhai et al.

Summary: During traumatic brain injury, increased expression of circulatory miR-21 can serve as a diagnostic feature. Low levels of exosome-miR-21 in the brain can improve neuroinflammation and BBB permeability, and Rg1 can protect BBB integrity by inhibiting the release of Exos-miR-21.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Health Care Sciences & Services

The Epidemiology and Genetics of Hyperuricemia and Gout across Major Racial Groups: A Literature Review and Population Genetics Secondary Database Analysis

Faven Butler et al.

Summary: Gout is an inflammatory condition caused by elevated serum urate, with different populations having varying levels of hyperuricemia and gout prevalence due to genetic variations in urate transporters. Asian populations (specifically CHS and JPT) have higher frequencies of urate-related risk alleles, possibly explaining the higher gout prevalence among Asians compared to Caucasians in healthcare settings.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Endocrinology & Metabolism

Low Plasma Adiponectin in Risk of Type 2 Diabetes: Observational Analysis and One- and Two-Sample Mendelian Randomization Analyses in 756,219 Individuals

Maria B. Nielsen et al.

Summary: The study found that low plasma adiponectin is associated with an increased risk of type 2 diabetes, and this association may be causal. Observational analysis and genetic Mendelian randomization were used to confirm the relationship between plasma adiponectin levels and type 2 diabetes risk.

DIABETES (2021)

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Article Pharmacology & Pharmacy

The Traditional Chinese Medicine Compound Huangqin Qingre Chubi Capsule Inhibits the Pathogenesis of Rheumatoid Arthritis Through the CUL4B/Wnt Pathway

Xiao Wang et al.

Summary: Research suggests that circ_0015756 and miR-942-5p are involved in the pathogenesis of rheumatoid arthritis, leading to abnormal proliferation of synovial cells; Huangqin Qingre Chubi Capsule inhibits the pathogenesis of RA through the CUL4B/Wnt pathway, showing a good therapeutic effect.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Cell Biology

Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis

Yanna Lei et al.

Summary: The study demonstrates that pitavastatin can prevent vascular senescence and atherogenesis induced by chronic stress and high fat diet in mice, potentially by increasing GLP-1 and APN levels and suppressing plaque inflammation and oxidative stress.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Gastroenterology & Hepatology