4.7 Article

A consensus phosphoserine within the large cytoplasmic loop of insect nAChR?8 subunits modulated interaction between 14-3-3? and nAChRs to regulate neonicotinoid efficacy

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Robust functional expression of insect nicotinic acetylcholine receptors provides new insights into neonicotinoid actions and new opportunities for pest and vector control

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Summary: Neonicotinoids are selective modulators of insect nicotinic acetylcholine receptors, interacting with orthosteric sites to activate and block receptor responses. While the mechanism of selectivity and diversity of neonicotinoid actions has been studied, many details of insecticide interactions with nAChR sites remain unresolved.

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