Discovery of novel phenothiazine derivatives as new agrochemical alternatives for treating plant viral diseases

Article Pharmacology & Pharmacy

Phenothiazines inhibit SARS-CoV-2 cell entry via a blockade of spike protein binding to neuropilin-1

Mei Hashizume et al.

Summary: The study reveals that dopamine receptor D2 (DRD2) antagonists can inhibit the binding of SARS-CoV-2 to neuropilin-1 (NRP-1), potentially leading to the development of novel antiviral therapeutics.

ANTIVIRAL RESEARCH (2023)

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Article Agronomy

Discovery of glyantrypine-family alkaloids as novel antiviral and antiphytopathogenic-fungus agents

Ya-nan Hao et al.

Summary: "Novel glyantrypine-family alkaloids and their derivatives were synthesized and evaluated for anti-TMV and fungicidal activities for the first time. Compounds 18d and 28d showed excellent antiviral activities, while compound 7bc exhibited remarkable fungicidal activity. These compounds have potential as lead compounds in plant protection."

PEST MANAGEMENT SCIENCE (2022)

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Article Agronomy

Ferulic acid derivatives with piperazine moiety as potential antiviral agents

Ting Yuan et al.

Summary: By synthesizing and screening, novel ferulic acid derivatives were discovered to have excellent antiviral activity, among which compound E2 exhibited remarkable curative activities against tobacco mosaic virus and cucumber mosaic virus. The outstanding antiviral activity of compound E2 was achieved by increasing host photosynthesis, making it a potential lead structure for the development of new antiviral agents.

PEST MANAGEMENT SCIENCE (2022)

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Article Agronomy

Discovery of novel rost-4-ene derivatives as potential plant activators for preventing phytopathogenic bacterial infection: Design, synthesis and biological studies

Fang Wang et al.

Summary: This study focused on the design, synthesis, and investigation of novel androst-4-ene derivatives as potential agrochemicals for controlling bacterial diseases in plants. The target compounds showed high antibacterial activity against destructive phytopathogenic bacteria and exhibited excellent protective effects in vivo. The mechanism of action involved enhancing host defense and inducing resistance, as well as disrupting the bacterial cell membrane.

PEST MANAGEMENT SCIENCE (2022)

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Article Agricultural Engineering

Identification of vanillic acid and its new amide derivative from Hyoscyamus niger and their modes of action in controlling tobacco mosaic virus

Zilong Hu et al.

Summary: This study identifies compounds extracted from the seeds of Hyoscyamus niger L. that show potential as antiviral agents and plant immune elicitors for controlling tobacco mosaic virus (TMV). The compounds, including vanillic acid and its amide derivative, demonstrated high efficacy in inhibiting TMV and inducing plant resistance. Further research is needed for the development of these compounds as biopesticides.

INDUSTRIAL CROPS AND PRODUCTS (2022)

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Article Agriculture, Multidisciplinary

1,3,4-Oxadiazole Derivatives as Plant Activators for Controlling Plant Viral Diseases: Preparation and Assessment of the Effect of Auxiliaries

Jin Ji et al.

Summary: Plant viral diseases cause significant economic losses in agriculture, therefore the development of efficient and low-dosage agrochemicals is important for protecting crop health and food security. In this study, a series of 1,3,4-oxadiazole derivatives were prepared and their inhibitory activity against tobacco mosaic virus (TMV) was evaluated. Compound A14 showed excellent anti-TMV protective activity, outperforming other tested compounds. Additionally, some compounds exhibited enhanced anti-TMV activity when supplemented with auxiliaries. Biochemical assays revealed that compound A14 could suppress TMV biosynthesis and induce plant defense response. These designed compounds have outstanding bioactivity and unique action mechanisms, making them promising candidates for controlling plant viral diseases.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Agronomy

Anti-TMVactivity and mode of action of three alkaloids isolated fromChelidonium majus

Wenhui Guo et al.

Summary: Plant viral diseases are difficult to control and pose serious threats to the agricultural industry. Biopesticides derived from botanical sources, such as the alkaloids chelerythrine and chelidonine isolated from Chelidonium majus, show significant potential as antiviral agents against tobacco mosaic virus (TMV), providing important evidence for developing new virus disease control measures in agriculture.

PEST MANAGEMENT SCIENCE (2021)

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Article Agriculture, Multidisciplinary

Synthesis and Biological Evaluation of 1,2,4-Triazole Thioethers as Both Potential Virulence Factor Inhibitors against Plant Bacterial Diseases and Agricultural Antiviral Agents against Tobacco Mosaic Virus Infections

Wu-Bin Shao et al.

Summary: Targeting the virulence factors of phytopathogenic bacteria is a novel strategy for disease control. Compound A10 showed significant inhibition of Xoo virulence factors and antiviral activity against tobacco mosaic virus, indicating its potential as a versatile agricultural chemical.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Design, synthesis and anti-TMV activity of novel α-aminophosphonate derivatives containing a chalcone moiety that induce resistance against plant disease and target the TMV coat protein

Xiang Zhou et al.

Summary: This study designed and synthesized a series of novel compounds with antiviral activity, and found that some of these compounds exhibited improved curative activity against tobacco mosaic virus (TMV) and could activate plant resistance against TMV infection. The compounds were shown to interact strongly with TMV Coat Protein, triggering disassembly of the virus and offering new insights for discovering antiviral compounds with different mechanisms of action.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2021)

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Article Multidisciplinary Sciences

Rapid test to assess the escape of SARS-CoV-2 variants of concern

Jacob T. Heggestad et al.

Summary: CoVariant-SCAN is a rapid test developed to detect neutralizing antibodies against different SARS-CoV-2 variants, showing consistent results with live virus neutralization assays and aiding in the rapid assessment of antibody response.

SCIENCE ADVANCES (2021)

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Article Agriculture, Multidisciplinary

Synthesis, Antibacterial Activity, and Mechanisms of Novel 6-Sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole Derivatives

Sikai Wu et al.

Summary: A series of novel 6-sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. The established CoMFA models were used to analyze and design compounds with higher activities, revealing their mechanisms of action in disease resistance.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Biotechnology & Applied Microbiology

Antibacterial properties of phenothiazine derivatives against multidrug-resistant Acinetobacter baumannii strains

L. Aguilar-Vega et al.

Summary: The study demonstrates that phenothiazine derivatives, especially chlorpromazine, exhibit attractive antibacterial properties against nosocomial multidrug-resistant strains of A. baumannii by generating reactive oxygen species (ROS) and causing cell membrane and DNA damage. Chlorpromazine also shows synergy with various antibiotics and is effective in treating experimentally infected Galleria mellonella when combined with ceftazidime. Repurposing phenothiazine derivatives for treating resistant infections by A. baumannii shows promising potential.

JOURNAL OF APPLIED MICROBIOLOGY (2021)

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Article Agronomy

Identification of anti-TMV active flavonoid glycosides and their mode of action on virus particles from Clematis lasiandra Maxim

Yantao Li et al.

Summary: Flavonoid glycosides from Clematis lasiandra showed potent antiviral activities against TMV with multiple modes of action including inactivation, protective and curative effects, and inducing systemic resistance. TMV-CP was an important target for active flavonoid glycosides to fracture TMV particles, suggesting the potential for controlling TMV with natural products.

PEST MANAGEMENT SCIENCE (2021)

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Article Agronomy

Pityriacitrin marine alkaloids as novel antiviral and anti-phytopathogenic-fungus agents

Tie-Nan Wang et al.

Summary: Plant diseases have been a major issue in agricultural production, impacting crop growth and yields. Marine natural products, specifically pityriacitrin alkaloids, were synthesized and evaluated for their antiviral and fungicidal activities. Compounds 3a and 5f showed promising results as new candidates for antiviral and fungicidal research, providing a new avenue for the development of novel inhibitors against plant viruses and fungi.

PEST MANAGEMENT SCIENCE (2021)

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Article Agriculture, Multidisciplinary

Target Discovery in Ralstonia solanacearum through an Activity-Based Protein Profiling Technique Based on Bioactive Oxadiazole Sulfones

Biao Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Agriculture, Multidisciplinary

Discovery of Tryptanthrins as Novel Antiviral and Anti-Phytopathogenic-Fungus Agents

Yanan Hao et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Agronomy

Synthesis of novel 18β-glycyrrhetinic piperazine amides displaying significant in vitro and in vivo antibacterial activities against intractable plant bacterial diseases

Meng Xiang et al.

PEST MANAGEMENT SCIENCE (2020)

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Article Agronomy

Synthetic chloroinconazide compound exhibits highly efficient antiviral activity against tobacco mosaic virus

Xing Lv et al.

PEST MANAGEMENT SCIENCE (2020)

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Editorial Material Biochemistry & Molecular Biology

Pandemics of People and Plants: Which Is the Greater Threat to Food Security?

Sylvia He et al.

MOLECULAR PLANT (2020)

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Article Plant Sciences

Hydrogen sulfide is required for salicylic acid-induced chilling tolerance of cucumber seedlings

Dong-Yun Pan et al.

PROTOPLASMA (2020)

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Review Virology

Climate change and plant virus epidemiology

Piotr Trebicki

VIRUS RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Discovery of Dithioacetal Derivatives Containing Sulfonamide Moiety of Novel Antiviral Agents by TMV Coat Protein as a Potential Target

Yuyuan Yang et al.

ACS OMEGA (2020)

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Review Pharmacology & Pharmacy

Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review

Michal Otreba et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Chemistry, Multidisciplinary

New chalcone derivatives: synthesis, antiviral activity and mechanism of action

Yun Fu et al.

RSC ADVANCES (2020)

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Article Agriculture, Multidisciplinary

Novel 1,3,4-Oxadiazole-2-carbohydrazides as Prospective Agricultural Antifungal Agents Potentially Targeting Succinate Dehydrogenase

Yuan-Yuan Wu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Review Food Science & Technology

Agro-defense: Biosensors for food from healthy crops and animals

Suresh Neethirajan et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2018)

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Review Microbiology

Recent Advances on the Multiplex Molecular Detection of Plant Viruses and Viroids

Vicente Pallas et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Editorial Material Medicine, General & Internal

History of Medicine Influenza Cataclysm, 1918

David M. Morens et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Chemistry, Medicinal

Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties

Krystian Pluta et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Article Chemistry, Multidisciplinary

Synthesis of novel 1,3,4-oxadiazole derivatives containing diamides as promising antibacterial and antiviral agents

Pei-Yi Wang et al.

RESEARCH ON CHEMICAL INTERMEDIATES (2017)

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Review Plant Sciences

Antagonistic within-host interactions between plant viruses: molecular basis and impact on viral and host fitness

Jerzy Syller et al.

MOLECULAR PLANT PATHOLOGY (2016)

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Article Agronomy

Design, synthesis, antiviral activity and three-dimensional quantitative structure-activity relationship study of novel 1,4-pentadien-3-one derivatives containing the 1,3,4-oxadiazole moiety

Xiuhai Gan et al.

PEST MANAGEMENT SCIENCE (2016)

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Review Agronomy

Propesticides and their use as agrochemicals

Peter Jeschke

PEST MANAGEMENT SCIENCE (2016)

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Article Plant Sciences

Cooperative functioning between phenylalanine ammonia lyase and isochorismate synthase activities contributes to salicylic acid biosynthesis in soybean

M. B. Shine et al.

NEW PHYTOLOGIST (2016)

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Article Biochemistry & Molecular Biology

New Strategies and Methods to Study Interactions between Tobacco Mosaic Virus Coat Protein and Its Inhibitors

Xiangyang Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Biotechnology & Applied Microbiology

Bio-based resistance inducers for sustainable plant protection against pathogens

Lenka Burketova et al.

BIOTECHNOLOGY ADVANCES (2015)

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Article Biochemistry & Molecular Biology

Induction of systemic resistance against tobacco mosaic virus by Ningnanmycin in tobacco

Yongguang Han et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2014)

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Review Biochemistry & Molecular Biology

Chlorophyll breakdown in higher plants

Stefan Hoertensteiner et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2011)

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Review Chemistry, Medicinal

Recent progress in biological activities of synthesized phenothiazines

Krystian Pluta et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)

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Review Plant Sciences

Top 10 plant viruses in molecular plant pathology

Karen-Beth G. Scholthof et al.

MOLECULAR PLANT PATHOLOGY (2011)

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Review Pharmacology & Pharmacy

Phenothiazine: The parent molecule

S. C. Mitchell

CURRENT DRUG TARGETS (2006)

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Review Agriculture, Multidisciplinary

Systemic acquired resistance in crop protection: From nature to a chemical approach

F Gozzo

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2003)

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Review Biotechnology & Applied Microbiology

Molecular biology and application of plant peroxidase genes

K Yoshida et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2003)

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Article Pharmacology & Pharmacy

Novel phenothiazine antimalarials: synthesis, antimalarial activity, and inhibition of the formation of beta-haematin

M Kalkanidis et al.

BIOCHEMICAL PHARMACOLOGY (2002)

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Discovery of novel phenothiazine derivatives as new agrochemical alternatives for treating plant viral diseases

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