期刊
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
卷 26, 期 3, 页码 310-317出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/10935266231166548
关键词
autopsy; stillbirth; placenta; placental insufficiency; cardiac hypertrophy
Placental maternal vascular malperfusion (MVM) is associated with fetal growth restriction (FGR). In autopsied stillbirths, it was found that stillbirths caused by MVM had relatively less impact on heart weight compared to body weight. Therefore, the effect of MVM on fetal cardiac structure is minimal and further research is needed in this area.
Background: Placental maternal vascular malperfusion (MVM) is associated with fetal growth restriction (FGR). While FGR increases the risk of cardiovascular disease, the impact of MVM on fetal cardiac structure is understudied. Methods: We utilized a cohort of autopsied stillbirths; 29 with MVM as the cause of death and 21 with a cause of death unrelated to MVM. Fetal and organ weights and heart measurements were standardized by gestational age and compared between MVM and non-MVM stillbirths. Differences in standardized fetal organ and cardiac measures as compared to standardized fetal body weight were calculated to account for body size. Results: MVM stillbirths had smaller organ and heart weights than non-MVM stillbirths; however, after accounting for gestational age, heart weight was the least affected among all organs. In an analysis of organ weights relative to body size, heart weights were 0.31 standard deviations (SD) larger than expected relative to body weight (95% CI: 0.04, 0.57). Right and left ventricle thicknesses and mitral valve circumference were also larger than expected relative to body weight. Conclusion: Stillbirth due to MVM was associated with relative sparing of heart weight and other heart measurements. The significance of these findings in liveborn infants needs further study.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据