Impact of DNA mismatch repair proteins deficiency on number and ratio of lymph nodal metastases in colorectal adenocarcinoma

Article Oncology

Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update

Nancy N. Baxter et al.

Summary: The study aims to develop recommendations for adjuvant therapy for patients with resected stage II colon cancer.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Review Oncology

BRAF-mutated colorectal adenocarcinomas: Pathological heterogeneity and clinical implications

Valentina Angerilli et al.

Summary: Molecular biology has greatly increased our understanding of the heterogeneous molecular landscape of colorectal cancer (CRC), with up to 15% of CRC patients harboring the BRAF p.V600E somatic mutation (BRAFmt), a negative prognostic marker in patients with metastatic CRC (mCRC). BRAF mutational testing is now recommended in mCRC patients, but efforts are needed to further stratify patients carrying this mutation.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

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Letter Medicine, General & Internal

Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas

David J. Papke et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Review Oncology

Diagnosis of digestive system tumours

Mary Kay Washington et al.

Summary: The WHO Classification of Tumours provides international standards for classification and diagnosis, with the latest fifth edition going digital and including a series of books. This article summarizes major diagnostic innovations from the past decade that have been incorporated into the classification.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Global colorectal cancer burden in 2020 and projections to 2040

Yue Xi et al.

Summary: Colorectal cancer is a major global public health challenge with higher incidence rates in developed countries and increasing trends in middle- and low-income countries. The rise of early-onset colorectal cancer is also seen. Increasing awareness, promoting healthy lifestyle choices, and implementing global screening programs are crucial in reducing the morbidity and mortality of colorectal cancer in the future.

TRANSLATIONAL ONCOLOGY (2021)

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Review Oncology