Ferroptosis in cancer stem cells

Ferroptosis is an iron-dependent form of RCD correlates with the accumulation of markers of lipid peroxidation. Bulks of studies focusing on revealing ferroptosis and its regulators involved in oncogenic pathways. Connection between iron metabolism and abnormal iron metabolism in CSCs synergistically making ferroptosis a target process of great potential in combating with CSCs to improve therapeutic effectiveness and reverse resistance. Ferroptosis inducers could specifically induce CSCs death in tumors, predisposing ferroptosis to a target in killing CSCs to overcome cancer resistances. By ferroptosis induction and other cell death pathways in CSCs, cancer therapeutic outcome would be improved.

Automated summary

Ferroptosis is an iron-dependent form of cell death that is associated with the accumulation of lipid peroxidation markers. Numerous studies have focused on uncovering the oncogenic pathways and regulators of ferroptosis. The connection between iron metabolism and abnormal iron metabolism in CSCs synergistically positions ferroptosis as a promising target in combating CSCs and reversing resistance. Ferroptosis inducers have the potential to specifically kill CSCs in tumors, making ferroptosis a target for overcoming cancer resistances. By inducing ferroptosis and other cell death pathways in CSCs, the therapeutic outcome of cancer can be improved.