期刊
ORGANOMETALLICS
卷 42, 期 7, 页码 588-596出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.3c00007
关键词
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In this article, a method for the synthesis of N,N'-diphenyl urea and N-phenyl carbamate by transition-metal-catalyzed carbonylation is introduced. The reaction proceeds through sequential amine C-H bond activation, carbonyl insertion, nucleophilic attack, and oxidation. Moreover, the indenones obtained with Mo(CO)6 as a CO surrogate can be functionalized to form synthetic useful derivatives.
Catalytic carbonylation of transition metals is widely used as an effective means to synthesize carbonyl-containing compounds. In this article, we introduce a method for the synthesis of N,N '-diphenyl urea and N-phenyl carbamate by transition -metal-catalyzed carbonylation. Here, we use Mo(CO)6 as a safe and stable carbonyl source to introduce the reaction to produce carbonylation products and achieve the selective formation of N,N '-diphenylurea and N-phenylcarbamate under mild conditions. Mechanistic investigations suggested that the reaction proceeded through sequential amine C-H bond activation, carbonyl insertion, nucleophilic attack, and oxidation of Pd(0) with Cu(OAc)2 to generate N-phenyl carbamate and N,N-diphenyl urea products. Moreover, the indenones obtained with Mo(CO)6 as a CO surrogate can be functionalized to form synthetic useful derivatives via an environmentally friendly way.
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