期刊
ORGANIC LETTERS
卷 25, 期 10, 页码 1760-1764出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c00478
关键词
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Quinolizidomycins A (1) and B (2), novel quinolizidine alkaloids, were discovered from Streptomyces sp. KIB-1714. Their structures were determined using spectroscopic methods and X-ray diffraction. Isotope labeling experiments revealed that compounds 1 and 2 are assembled from lysine, ribose 5-phosphate, and acetate units, representing an unprecedented biosynthetic pathway for the quinolizidine scaffold. Quinolizidomycin A (1) exhibited activity in an acetylcholinesterase inhibitory assay.
Quinolizidomycins A (1) and B (2), two unprecedented quinolizidine alkaloids featuring a tricyclic 6/6/5 ring system, were isolated from Streptomyces sp. KIB-1714. Their structures were assigned by detailed spectroscopic data analyses and X-ray diffraction. Stable isotope labeling experiments suggested that compounds 1 and 2 are derived from lysine, ribose 5-phosphate, and acetate units, which indicates an unprecedented manner of assembly of the quinolizidine (1-azabicyclo[4.4.0]decane) scaffold in quinolizidomycin biosynthesis. Quinolizidomycin A (1) was active in an acetylcholinesterase inhibitory assay.
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