期刊
ORGANIC LETTERS
卷 25, 期 23, 页码 4329-4334出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01427
关键词
-
An inexpensive iron-catalyzed alkoxylradical-induced C-C bond cleavage/gem-difluoroalkylation cascade is developed. Fluorinated distal diketones are synthesized via a ring-opening strategy regulated by the structure of alkoxyl radical precursors, while difluoroalkylated medium-sized lactones and macrolactones are constructed through a ring-expansion strategy. Both protocols show mild and redox neutral conditions, broad substrate scope, and good functional group compatibility.
An inexpensive iron-catalyzed alkoxylradical-inducedC-Cbond cleavage/gem-difluoroalkylation cascade is presented.Regulated by the structure of alkoxyl radical precursors, fluorinateddistal diketones were synthesized through a ring-opening strategyand difluoroalkylated medium-sized lactones and macrolactones wereconstructed via a ring-expansion strategy. Both protocols proceededunder mild and redox neutral conditions with a broad substrate scopeand good functional group compatibility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据