期刊
ORGANIC LETTERS
卷 25, 期 15, 页码 2571-2576出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c00498
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In this work, a palladium-catalyzed hydroalkoxycarbonylation and hydroxycarbonylation of cyclopent-3-en-1-ols is reported, which enables the synthesis of bridged bicyclic lactones and beta,gamma-unsaturated carboxylic acid. The reactivity of cyclopent-3-en-1-ols is controlled by the palladium catalyst and ligands. The reaction is additive-free and exhibits a broad substrate scope, allowing access to valuable synthetic and medical intermediates.
Herein, we report a palladium-catalyzed hydroalkoxycarbonylation and hydroxycarbonylation of cyclopent-3-en-1-ols to form bridged bicyclic lactones and beta,gamma-unsaturated carboxylic acid. The divergent reactivity of cyclopent-3-en-1-ols is mainly tuned by the palladium catalyst and ligands. The reaction occurs additive-free and has a broad substrate scope. Several valuable synthetic and medical intermediates are accessible through this protocol.
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