期刊
ORGANIC LETTERS
卷 25, 期 20, 页码 3623-3627出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c00943
关键词
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A direct synthesis of ketones by nickel-catalyzed deaminative cross-coupling of alkylpyridinium salts with thiopyridine esters has been reported. This approach offers an easy and efficient method for the synthesis of ketones from readily available feedstock chemicals, and has proven to be useful in the functionalization of complex bioactives and pharmaceuticals.
A direct synthesis of ketones by the nickel-catalyzeddeaminativecross-coupling of alkylpyridinium salts with thiopyridine esters hasbeen reported. The reaction works well for both primary and secondaryamines. This approach affords a highly valuable vista for the facilesynthesis of ketones from easily accessible feedstock chemicals. Theutility of this method is demonstrated through the functionalizationof complex bioactives and pharmaceuticals.
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