Chemospecific C3-and C2-Olefinations of Isatins by TfOH-Promoted Tandem Aldol-Grob and Semiacetalization-Grob Fragmentations

A novel method for TfOH-promoted chemospecific C3- andC2-olefinationsof isatins is developed, which offers the first examples of Grob fragmentationusing isatins and amides as substrates.

Automated summary

A novel method for chemospecific C3- and C2-olefinations of isatins using TfOH-promotion has been developed, presenting the first examples of Grob fragmentation with isatins and amides as substrates.