Electrochemical Isothiocyanation of Primary Amines

Isothiocyanates are ubiquitous building blocks used across the fields. Nevertheless, their classical syntheses very often rely on the use of toxic and expensive reagents. Herein, we report a new practical, mild, high-yielding, and supporting-electrolyte-free electrochemical method for the preparation of aliphatic and aromatic isothiocyanates from amine and carbon disulfide.

Automated summary

In this study, a new practical electrochemical method for the synthesis of aliphatic and aromatic isothiocyanates from amine and carbon disulfide is reported. The method is mild, high-yielding, and does not require the use of supporting electrolytes, making it a convenient and cost-effective alternative to classical syntheses.