期刊
ORGANIC LETTERS
卷 25, 期 20, 页码 3664-3669出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01030
关键词
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This article describes a palladium-catalyzed photoinduced N-to-alkyl radical relay Heck reaction, where o-alkylbenzamides at benzylic sites are reacted with vinyl arenes. The reaction does not require exogenous photosensitizers or external oxidants, and is proposed to proceed via a N-to-alkyl hybrid palladium-radical mechanism. The reaction occurs under mild conditions, allowing a wide range of functional groups to be compatible. The products can be easily transformed into azepinone derivatives, which are commonly found in pharmaceuticals and natural products.
Here,a palladium-catalyzed photoinduced N-to-alkyl radical relayHeck reaction of o-alkylbenzamides at benzylic siteswith vinyl arenes is described. The reaction employs neither exogeneousphotosensitizers nor external oxidants. It is proposed to proceedvia a N-to-alkyl hybrid palladium-radical mechanism which occursunder mild conditions that are compatible with a wide range of functionalgroups. The products are easily transformed to azepinone derivatives,which are prevalent in pharmaceuticals and natural products.
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