Unlocking Regiodivergence in PdII- and RhIII-Mediated Site-Selective C-H Bond Alkynylation of Imidazopyridines

An efficient Pd-II- and Rh-III-controlled site-selective C-H bond alkynylation of imidazopyridines using (bromoethynyl)triisopropylsilane is disclosed. The divergent methodology allows straightforward access to a wide range of products alkynylated at the C3 and ortho positions. This strategy is suggestive of a practical platform that can be suitable for late stage diversification and may assist in the design of more selective and complementary catalytic systems.

Automated summary

An efficient Pd-II- and Rh-III-controlled site-selective C-H bond alkynylation of imidazopyridines using (bromoethynyl)triisopropylsilane is described, providing access to a wide range of products alkynylated at the C3 and ortho positions. This methodology shows potential as a practical platform for late stage diversification and could aid in the development of more selective and complementary catalytic systems.