期刊
CEREBRAL CORTEX
卷 26, 期 10, 页码 4034-4045出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhv191
关键词
autism spectrum disorder; default-mode network; executive control network; functional connectivity; salience network
资金
- National Institutes of Health [R01-MH081023, K01 MH097972]
- Autism Speaks Dennis Weatherstone Predoctoral Fellowship [7850]
- Congressionally Directed Medical Research Programs (CDMRP) [AR093335]
- CDMRP [544489, AR093335] Funding Source: Federal RePORTER
Autism spectrum disorder (ASD) is characterized by atypical brain network organization, but findings have been inconsistent. While methodological and maturational factors have been considered, the network specificity of connectivity abnormalities remains incompletely understood. We investigated intrinsic functional connectivity (iFC) for four core functional networks-default-mode (DMN), salience (SN), and left (lECN) and right executive control (rECN). Resting-state functional MRI data from 75 children and adolescents (37 ASD, 38 typically developing [TD]) were included. Functional connectivity within and between networks was analyzed for regions of interest (ROIs) and whole brain, compared between groups, and correlated with behavioral scores. ROI analyses showed overconnectivity (ASD > TD), especially between DMN and ECN. Whole-brain results were mixed. While predominant overconnectivity was found for DMN (posterior cingulate seed) and rECN (right inferior parietal seed), predominant underconnectivity was found for SN (right anterior insula seed) and lECN (left inferior parietal seed). In the ASD group, reduced SN integrity was associated with sensory and sociocommunicative symptoms. In conclusion, atypical connectivity in ASD is network-specific, ranging from extensive overconnectivity (DMN, rECN) to extensive underconnectivity (SN, lECN). Links between iFC and behavior differed between groups. Core symptomatology in the ASD group was predominantly related to connectivity within the salience network.
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