Copper-Catalyzed Borylation and Silylation of Dichlorocyclobutenones

We report copper-catalyzed borylation and silylation of dichlorocyclobutenones, which furnish the boron-substituted and silicon -substituted polyfunctionalized cyclobutenones in high yields. The reactions proceed under mild reaction conditions, show broad substrate scope, and display high chemoselectivity. In addition, a series of transformations of the corresponding products has been realized.

Automated summary

This study reports the copper-catalyzed borylation and silylation of dichlorocyclobutenones, leading to the synthesis of boron-substituted and silicon-substituted polyfunctionalized cyclobutenones with high yields. The reactions occur under mild conditions, exhibit broad substrate scope, and show high chemoselectivity. Furthermore, a series of transformations of the resulting products have been achieved.