期刊
ORGANIC LETTERS
卷 25, 期 9, 页码 1425-1430出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c00157
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In this study, we present an improved system for the Cu-catalyzed enantioselective reductive coupling of ketones and allenamides by optimizing the allenamide to prevent on-cycle rearrangement. High enantioselectivities were achieved for various ketones. Unlike cyclic allenamides, which favor the syn-form, the acyclic allenamides described in this work selectively generated anti-diastereomers. A rationalization for this change in diastereoselectivity is also provided.
Herein, we report the development of an improved system for the Cu-catalyzed enantioselective reductive coupling of ketones and allenamides through the optimization of the allenamide to avoid an on-cycle rearrangement. High enantioselectivities could be obtained for a variety of ketones. Use of the acyclic allenamides described herein selectively generated anti-diastereomers in contrast to cyclic allenamides that were previously shown to favor the syn-form. A rationale for this change in diastereoselectivity is also presented.
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