K2S2O8-Induced [4+2] Annulation of Tertiary Anilines and Alkenes toward Tetrahydroquinolines

Due to the unique physicochemical properties of heterocyclic compounds, their construction is one of the central issues in synthetic chemistry. Here, we report a K2S2O8-induced protocol for constructing tetrahydroquinolines from bulk chemicals (alkenes and anilines). The merit of this method has been demonstrated by its operational simplicity, wide scope, mild conditions, and transition-metal-free system.

Automated summary

We report a protocol for constructing tetrahydroquinolines from bulk chemicals (alkenes and anilines) induced by K2S2O8. The method exhibits operational simplicity, wide scope, mild conditions, and a transition-metal-free system.