期刊
ORGANIC LETTERS
卷 25, 期 26, 页码 4945-4949出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01855
关键词
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We present a three-component interrupted click reaction to efficiently synthesize novel 5-pentafluoroethyl 1,2,3-triazoles from readily available terminal alkynes and azides. The key reagent [CuCF2CF3], derived from low-cost pentafluoroethane, exhibits orthogonal reactivity by facilitating cycloaddition instead of previous radical reactions. The reaction conditions are mild using air as a green oxidant.
Weherein describe a three-component interrupted clickreactionto synthesize novel 5-pentafluoroethyl 1,2,3-triazoles in one stepfrom readily available terminal alkynes and azides. The key reagent[CuCF2CF3], prepared from the low-cost gas pentafluoroethane,demonstrates an orthogonal reactivity in facilitating cycloadditionrather than previously reported radical reactions. Reaction conditionsare mild by using air as a green oxidant.
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