Designing a Light-Induced Glycosylation Reaction for Poststage Synthesis of ADP-2-Deoxyribosyl Derivatives

Modifications on the hydroxyl groups of ADP-ribosyl unitscan providevaluable tools for investigating ADP-ribosylation-related molecularinteractions, but the chemical syntheses of these compounds are usuallydifficult due to their inherent complex structures. In this study,we report a poststage synthetic protocol for accessing novel ADP-2 ''-deoxyribosylderivatives through designing a light-induced biomimetic reaction,and SPR assays revealed effective binding of ADP-2 ''-deoxyribosylpeptides to MacroH2A1.1 with a high affinity (K (D) = 3.75 x 10(-6) M).

Automated summary

In this study, a poststage synthetic protocol for accessing novel ADP-2''-deoxyribosylderivatives through designing a light-induced biomimetic reaction was reported, and SPR assays revealed effective binding of ADP-2''-deoxyribosylpeptides to MacroH2A1.1 with a high affinity (K(D) = 3.75 x 10(-6) M).