期刊
ORGANIC LETTERS
卷 25, 期 23, 页码 4241-4246出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01156
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We describe the selective cyclization of anilines with cyclobutanones and congeners using chromium catalysis. This reaction enables the formation of diastereoselective tetrahydroquinolines by linking two strained four-membered rings, leading to the synthesis of cyclobutane-fused and constrained spirotetrahydroquinolines (STHQs) and complex multiple spiro carbon-containing polyazacycles. The constrained STHQs have been utilized as versatile precursors for the synthesis of oxygen-, nitrogen-, and thio-substituted spiro analogues, as well as dioxygen-incorporated spiroazacycles.
We report the diastereoselective cyclization of anilineswith cyclobutanonesand congeners by chromium catalysis. This reaction can link two strainedfour-membered rings with tetrahydroquinolines by forming four bondsin a diastereocontrolled manner, forming medicinally interesting cyclobutane-fusedand constrained spirotetrahydroquinolines (STHQs) and complex multiplespiro carbon-containing polyazacycles. The constrained STHQs havebeen used as versatile feedstocks to derive a range of oxygen-, nitrogen-,and thio-substituted spiro analogues, and dioxygen-incorporated spiroazacycles.
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