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Article
Biochemistry & Molecular Biology
Shanshan Liu et al.
Summary: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck with a poor prognosis and unsatisfactory treatment. This study found that the protein histidine phosphatase LHPP plays an important role in the development of OSCC. LHPP inhibits the growth and migration of OSCC by decreasing the activity of the PI3K/AKT signaling pathway and promoting apoptosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhe Sun et al.
Summary: Head and neck squamous cell carcinoma (HNSCC) is influenced by both environmental factors and genetic mutations. Current standard treatment modalities for HNSCC, including surgery, chemotherapy, and radiotherapy, have not improved patient survival rates. The use of peptide cancer vaccines shows promise in improving outcomes, but further research is needed.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2022)
Review
Cell Biology
Sara Adnane et al.
Summary: Recent studies have shown that long noncoding RNAs play a crucial role in cancer by regulating LLPS. This discovery may lead to the development of new diagnostic tools and treatment methods.
TRENDS IN CELL BIOLOGY
(2022)
Review
Oncology
Douglas Hanahan
Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.
Article
Biotechnology & Applied Microbiology
Fanqi Meng et al.
Summary: This article reports that LINC00525, a hypoxia-responsive lncRNA, is essential for hypoxia-enhanced glycolysis in colorectal cancer cells. It was found that LINC00525 promotes UBE2Q1 expression by binding miR-338-3p, leading to the activation of HIF-1α and enhanced glycolysis under hypoxic conditions.
Review
Dentistry, Oral Surgery & Medicine
N. Graillon et al.
Summary: This study provides a concise review of National Cancer Database (NCDB) studies on oral cavity squamous cell carcinoma (OCSCC), highlighting four areas of research focus and emphasizing factors related to prognosis and treatment of OCSCC.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Cell Biology
Wen Li et al.
Summary: This study identified long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs associated with CDK1 in lung adenocarcinoma (LUAD) patients. The regulatory axis of LINC00460/LINC00525-hsa-mir-338-FAM111B/ZWINT was determined, and abnormal up-regulation of FAM111B/ZWINT was found to be related to hypomethylation in LUAD. Results also suggested that FAM111B/ZWINT could affect LUAD development and prognosis by regulating the immune microenvironment and promoting tumor spread through EMT. Potential target medicines for LUAD treatment were identified using bioinformatics analysis.
Article
Biochemistry & Molecular Biology
Futai Gong et al.
Summary: The study identified that LINC00525 is highly expressed in spinal chordoma, while miR-31-5p and miR-125a-5p levels are low. Downregulation of LINC00525 inhibited the proliferation, migration, invasion, and promoted apoptosis in spinal chordoma cells, suggesting that LINC00525 targets miR-31-5p and miR-125a-5p to promote tumorigenesis and progression in spinal chordoma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Shusuke Toden et al.
Summary: Recent advances have highlighted the importance of non-coding RNAs, particularly microRNAs, in cancer pathogenesis. These ncRNAs have shown potential for therapeutic development in cancer, with early data from pre-clinical studies demonstrating promising results in human trials. While miRNAs have been extensively studied, there is ongoing research to uncover the molecular mechanisms and therapeutic targets of other lesser studied ncRNAs in cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Cell Biology
Luisa Statello et al.
Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Review
Oncology
Elle Koren et al.
Summary: Cell suicide pathways, known as regulated cell death (RCD), are crucial in organismal development, homeostasis, and pathogenesis. This review discusses key RCD modalities such as apoptosis, entosis, necroptosis, pyroptosis, and ferroptosis, and how they serve as a defense mechanism against cancer while also being exploited in oncogenesis. Therapeutic agents that activate RCD are outlined, along with novel strategies for tumor elimination, highlighting the critical importance of RCD in combating cancer.
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Oncology
Ambika Chamoli et al.
Summary: Oral cavity squamous cell carcinoma is the most common malignancy in the oral cavity, with risk factors such as tobacco and alcohol consumption. Late diagnosis leads to decreased survival rates. Understanding the genetic alterations and molecular mechanisms involved is crucial for developing targeted treatments for oral cavity cancer.
Review
Medicine, General & Internal
Mayur D. Mody et al.
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Biotechnology & Applied Microbiology
Melanie Winkle et al.
Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Oncology
Panqi Fang et al.
Summary: The long noncoding RNA LINC00525 is highly expressed in LUAD and promotes tumor progression by reducing the transcription and stability of p21 mRNA through interactions with EZH2 and RBMS2. It may serve as a potential therapeutic target for clinical intervention in LUAD.
CANCER COMMUNICATIONS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Linah A. Shahoumi
Summary: Head and neck squamous cell carcinoma (HNSCC) is a highly diverse group of tumors with poor prognosis, especially in developing countries. Cancer stem cells (CSCs) play a significant role in therapeutic resistance and metastasis of HNSCC, making targeted therapies against CSCs a promising approach to improve clinical outcomes. Additional studies on combination therapies targeting head and neck CSCs may lead to significant advancements in disease management.
FRONTIERS IN ORAL HEALTH
(2021)
Review
Oncology
Gregory J. Goodall et al.
Summary: Recent findings have shown that RNA processing is systematically altered in cancer, with mutations in RNA splicing factor genes and the shortening of 3' untranslated regions widely observed. Additionally, evidence suggests that other types of RNAs, including circular RNAs, can contribute to tumorigenesis.
NATURE REVIEWS CANCER
(2021)
Article
Biochemistry & Molecular Biology
Hailong Ma et al.
Review
Cell Biology
Sammy Bedoui et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2020)
Article
Genetics & Heredity
Sijie Zhou et al.
FRONTIERS IN GENETICS
(2020)
Article
Medicine, General & Internal
Daniel E. Johnson et al.
NATURE REVIEWS DISEASE PRIMERS
(2020)
Article
Oncology
Yingying Jiang et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Cell & Tissue Engineering
Shunsheng Wang et al.
INTERNATIONAL JOURNAL OF STEM CELLS
(2019)
Review
Biochemistry & Molecular Biology
Florian Kopp et al.
Review
Biochemistry & Molecular Biology
Gayatri Arun et al.
TRENDS IN MOLECULAR MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Ru Wang et al.
Review
Oncology
Adriana Sanchez-Danes et al.
NATURE REVIEWS CANCER
(2018)
Review
Oncology
Ranui Baillie et al.
FRONTIERS IN ONCOLOGY
(2017)
Review
Cell Biology
Flore Kruiswijk et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2015)
Article
Biochemical Research Methods
Nicolaas A. P. Franken et al.
