期刊
CEREBRAL CORTEX
卷 25, 期 11, 页码 4374-4391出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhv024
关键词
ALE meta-analysis; anterior temporal lobes; conceptual knowledge; laterality; semantic memory
资金
- EPSRC
- President's Doctoral Scholarship from University of Manchester
- MRC Programme Grant [MR/J004146/1]
- Manchester Mental Health Social Care Trust Fellowship
- Wellcome Trust Institutional Strategic Support Fund (ISSF) award [097820]
- RCUK block grant
- MRC [MR/J004146/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [1237034] Funding Source: researchfish
- Medical Research Council [MR/J004146/1] Funding Source: researchfish
The roles of the right and left anterior temporal lobes (ATLs) in conceptual knowledge are a source of debate between 4 conflicting accounts. Possible ATL specializations include: (1) Processing of verbal versus non-verbal inputs; (2) the involvement of word retrieval; and (3) the social content of the stimuli. Conversely, the hub-and-spoke account holds that both ATLs form a bilateral functionally unified system. Using activation likelihood estimation (ALE) to compare the probability of left and right ATL activation, we analyzed 97 functional neuroimaging studies of conceptual knowledge, organized according to the predictions of the three specialized hypotheses. The primary result was that ATL activation was predominately bilateral and highly overlapping for all stimulus types. Secondary to this bilateral representation, there were subtle gradations both between and within the ATLs. Activations were more likely to be left lateralized when the input was a written word or when word retrieval was required. These data are best accommodated by a graded version of the hub-and-spoke account, whereby representation of conceptual knowledge is supported through bilateral yet graded connectivity between the ATLs and various modality-specific sensory, motor, and limbic cortices.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据