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Glioblastoma heterogeneity at single cell resolution

ONCOGENE (2023)

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Article Cell Biology

Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma

Sakthi Rajendran et al.

Summary: Recent studies have shown that the dynamic tumor microenvironment (TME) is important in high-grade gliomas (HGGs). It is still unclear whether myeloid cells play a role in the malignant progression of low-grade glioma (LGG). In this study, using single-cell RNA sequencing, the researchers investigated the cellular heterogeneity of the TME in a murine glioma model that mimics the progression from LGG to HGG. They found that LGGs have increased infiltrating T cells and natural killer cells in the TME, while HGGs lack this infiltration. The study also identified distinct macrophage clusters in the TME that exhibit an immune-activated phenotype in LGG but then transition to an immunosuppressive state in HGG.

CELL REPORTS (2023)

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Article Medicine, Research & Experimental

Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects

Saket Jain et al.

Summary: Research has discovered the presence of cancer-associated fibroblasts (CAFs) in glioblastoma, which interact with mesenchymal glioblastoma stem cells (GSCs). These findings suggest that CAFs could be a potential target for the treatment of glioblastoma.

JOURNAL OF CLINICAL INVESTIGATION (2023)

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Article Multidisciplinary Sciences

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target

Nourhan Abdelfattah et al.

Summary: This study identifies molecular phenotypes of immune-suppressive and -promoting myeloid cells in GBM through single cell RNA sequencing and discovers S100A4 as a regulator of immune suppressive T and myeloid cells in GBM. The study reveals extensive spatial and molecular heterogeneity in immune infiltrates and identifies nine distinct myeloid cell subtypes, with five being prognostic indicators of glioma patient survival.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10

Vidhya M. Ravi et al.

Summary: The study demonstrates that a subset of myeloid cells in Glioblastomas induce dysfunctional T cells through Interleukin-10 signaling, and inhibiting downstream JAK/STAT pathway could restore the responsiveness of immune therapy. The findings are validated using in vitro and in vivo models, providing further evidence of Interleukin-10 release being a driving force of tumor immune escape. Integrative modeling of single cell and spatial transcriptomics data proves to be a valuable tool for studying the tumor immune microenvironment and may contribute to the development of successful immunotherapies.

NATURE COMMUNICATIONS (2022)

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Article Oncology

Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity

Veronique G. LeBlanc et al.

Summary: Glioblastomas (GBMs) are highly heterogeneous brain tumors, and patient-derived models have been used to study this heterogeneity. However, the extent to which these models recapitulate GBM genomic features is still unclear. In this study, the researchers analyzed the genomes and transcriptomes of GBM tumors and patient-derived models, and found that the models exhibit genetic similarities to the tumors and retain varying gene expression characteristics. These findings provide valuable insights for using GBM-derived models to study cellular heterogeneity.

CANCER CELL (2022)

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Article Immunology

Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression

Alan T. Yeo et al.

Summary: Using single-cell transcriptomics and flow cytometry, this study investigated the changes in immune cell composition during the progression of glioblastoma (GBM). The results revealed a transition from pro-inflammatory microglia to infiltrating macrophages and suppressor cells as the tumor advanced.

NATURE IMMUNOLOGY (2022)

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Article Immunology

Characterising Distinct Migratory Profiles of Infiltrating T-Cell Subsets in Human Glioblastoma

Paris M. M. Kollis et al.

Summary: This study characterized the chemokine receptor and integrin expression profiles of endogenous glioblastoma-infiltrating T cells and identified potential homing receptor-ligand pairs that could enhance the tumour-homing properties of future T-cell immunotherapies for glioblastoma.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Genetics & Heredity

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Ilon Liu et al.

Summary: By analyzing the single-cell transcriptomics, epigenomics, and spatial architectures of a comprehensive cohort of H3-K27M DMGs, this study reveals the heterogeneity of these mutations at different ages and midline locations. The findings also provide insights into the cell-intrinsic and -extrinsic features of these tumors in relation to age and anatomical location, which can be used for rational modeling and therapeutic interventions.

NATURE GENETICS (2022)

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Article Oncology

Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma

Vidhya M. Ravi et al.

Summary: This study utilizes spatially resolved transcriptomics, metabolomics, and proteomics to characterize glioblastomas and uncover their spatial organization and adaptive mechanisms to inflammatory and metabolic stimuli. The integration of metabolic imaging and imaging mass cytometry reveals the interdependence between tumor and host in a locoregional manner, leading to spatially exclusive adaptive transcriptional programs. The findings confirm the importance of environmental stress in shaping glioblastoma subclones and their transcriptional programs.

CANCER CELL (2022)

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Article Multidisciplinary Sciences

Immunotherapy of glioblastoma explants induces interferon-γ responses and spatial immune cell rearrangements in tumor center, but not periphery

Tala Shekarian et al.

Summary: This study demonstrated that ex vivo immunotherapy of GBM explants can induce an active antitumoral immune response within the tumor center, providing a framework for multidimensional personalized assessment of tumor response to immunotherapy.

SCIENCE ADVANCES (2022)

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Article Medicine, Research & Experimental

Immune landscape of a genetically engineered murine model of glioma compared with human glioma

Daniel B. Zamler et al.

Summary: This study compared the immune microenvironment of glioblastoma in mouse models and patient samples and found that myeloid cells dominate the tumor microenvironment. Additionally, a higher abundance of neutrophils, T cells, and NK cells was observed in implanted mouse models and high-grade glioma patient samples.

JCI INSIGHT (2022)

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Article Oncology

A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets

Lin Wang et al.

Summary: Recent studies have shown that glioblastoma (GBM) lacks specific DNA mutations in recurrent disease, suggesting phenotype switching rather than genetic evolution as the mechanism of treatment failure. Using different assays, we analyzed GBM specimens and found a shift to a mesenchymal phenotype in recurrent GBMs mediated by activator protein 1. T-cell abundance at recurrence was prognostic and correlated with hypermutation status, and tumor-supportive networks involving GBM cells, nonmalignant neuroglia, and immune cells were identified.

NATURE CANCER (2022)

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Article Oncology

Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma

Lingxiang Wu et al.

Summary: This study investigates the natural evolutionary trajectory of glioblastoma (GBM) by using multifocal samples. The researchers identify a natural evolution signature (NES) in the tumor and find that it is associated with the activation of transcription factors involved in brain development. They also discover that hypoxia plays a role in inducing NES transition and that polarized macrophages can promote tumor cell migration and NES transition.

CANCER DISCOVERY (2022)

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Article Immunology

Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma

Catalina Lee-Chang et al.

Summary: The B-Vax vaccine developed in this study showed significant effects in activating autologous CD8(+) T cells and killing GBM cells, achieving an 80% tumor eradication rate in experimental animals.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Oncology

Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

Joseph M. Chan et al.

Summary: The study reveals a greater tumor diversity in SCLC compared to lung adenocarcinoma, with a PLCG2-high SCLC phenotype showing stem-like, pro-metastatic features and predicting worse overall survival. Furthermore, SCLC demonstrates greater immune sequestration and less immune infiltration than lung adenocarcinoma.

CANCER CELL (2021)

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Article Oncology

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Michael Weller et al.

Summary: The European Association of Neuro-Oncology (EANO) has released guidelines for the diagnosis, treatment, and follow-up of adult patients with diffuse gliomas, incorporating major changes in diagnostic algorithms based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System, as well as evidence from recent large clinical trials.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Biology

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

Paul Guilhamon et al.

Summary: This study uses chromatin accessibility to identify diverse self-renewing populations in glioblastoma, with three distinct states identified in glioblastoma stem cells. The characterization of these states improves prognostic precision and guides combination therapies for better treatment outcomes.

ELIFE (2021)

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Article Biochemistry & Molecular Biology

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

Nathan D. Mathewson et al.

Summary: This study utilized single-cell RNA sequencing to uncover the gene expression and clonal landscape of T cells in diffuse gliomas, identifying potential effectors of anti-tumor immunity. The research revealed that KLRB1 and its associated transcriptional program play an inhibitory role in tumor immunity, and blocking its function enhances T cell killing of glioma cells.

CELL (2021)

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Article Genetics & Heredity

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

Kevin C. Johnson et al.

Summary: Single-cell DNA methylation and transcriptomic glioma analyses reveal the association between local DNA methylation disorder and cellular plasticity, with implications for disease progression and therapeutic response shaping. Glioma cells exhibit increased DNA methylation disorder under environmental stress, highlighting an epigenetically facilitated adaptive stress response process.

NATURE GENETICS (2021)

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Article Biochemistry & Molecular Biology

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

Ester Gangoso et al.

Summary: In this study, it was found that GBM stem cells acquire the ability to evade immune clearance through epigenetic immunoediting, leading to the formation of an immunosuppressive tumor microenvironment. This process is not driven by genetic selection but by altering the transcriptional and epigenetic profile of GSCs after immune attack.

CELL (2021)

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Article Multidisciplinary Sciences

Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer

Ana Nikolic et al.

Summary: Single-cell epigenomic assays have great potential to study transcriptional control mechanisms in cancer cell populations, but distinguishing malignant from nonmalignant cells has been a challenge. Copy-scAT is an R package that uses single-cell epigenomic data to infer copy number variants specific to cancer cells, allowing for the study of chromatin dynamics in complex tumors like glioblastoma. The software revealed strong effects of genetics on chromatin accessibility profiles in genetic subclones, influencing their molecular phenotypes and developmental paradigms.

SCIENCE ADVANCES (2021)

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Article Multidisciplinary Sciences

G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy

Mahmoud S. Alghamri et al.

Summary: The efficacy of immune-stimulatory gene therapy is enhanced in mIDH1 gliomas due to the reprogramming of infiltrating myeloid cells, mainly non-suppressive neutrophils and pre-neutrophils, in the tumor microenvironment. This reprogramming is triggered by granulocyte colony-stimulating factor (G-CSF) secreted by mIDH1 glioma stem/progenitor-like cells, leading to non-inhibitory myeloid cells within the tumor microenvironment and enhancing the therapy's effectiveness.

SCIENCE ADVANCES (2021)

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Article Neurosciences

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Ana Rita Pombo Antunes et al.

Summary: By utilizing single-cell RNA sequencing and CITE-seq, this study reveals the complexity of the immune landscape in glioblastomas, including conserved populations of dendritic cells and macrophages. The results indicate that microglia-derived tumor-associated macrophages dominate in newly diagnosed tumors, but are replaced by monocyte-derived TAMs in recurrences.

NATURE NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

Eilam Yeini et al.

Summary: The study revealed the crucial role of P-selectin in promoting GB proliferation and invasion, showing that inhibiting P-selectin could reduce tumor growth and increase survival in mouse models. The findings shed light on the function of tumor-associated microglia/macrophages and the mechanisms by which GB cells suppress the immune system and invade the brain, paving the way to exploit P-selectin as a target for GB therapy.

NATURE COMMUNICATIONS (2021)

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Article Genetics & Heredity

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker

Andrew X. Chen et al.

Summary: This study identified a pro-tumor subpopulation of bone marrow-derived macrophages characterized by MARCO, which is exclusively found in IDH1-wild-type glioblastomas. MARCO expression is associated with worse prognosis and mesenchymal subtype, and significantly altered during treatment with anti-PD1 checkpoint inhibitors, suggesting potential therapeutic targets for preventing their recruitment.

GENOME MEDICINE (2021)

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Article Oncology

Brain and other central nervous system tumor statistics, 2021

Kimberly D. Miller et al.

Summary: Brain and other CNS tumors are highly fatal cancers in the United States, with different incidence rates and survival rates among different races and age groups. Survival disparities, especially in childhood tumors, highlight the importance of providing more resources to advance research and understand the reasons behind differences in brain tumor occurrence, especially among rarer subtypes and understudied populations.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

Modeling glioblastoma heterogeneity as a dynamic network of cell states

Ida Larsson et al.

Summary: The research establishes quantitative models of time-dependent transcriptional variation of patient-derived glioblastoma cells, revealing a hierarchical and plastic organization of GBM with cell state switching rates and patterns being partly patient-specific. Therapeutic interventions have complex dynamic effects, including inhibiting specific states and altering differentiation.

MOLECULAR SYSTEMS BIOLOGY (2021)

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Article Multidisciplinary Sciences

Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas

Karolina Stepniak et al.

Summary: By conducting whole-genome mapping of multiple tumor samples, researchers reveal an atlas of active enhancers and promoters in benign and malignant gliomas, uncovering epigenetic dysfunctions driving gliomagenesis.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Pro-inflammatory and proliferative microglia drive progression of glioblastoma

Hailong Liu et al.

Summary: Limited understanding of the glioblastoma microenvironment and molecular mechanisms complicates the development of effective treatment strategies. This study unveils the correlation between SETD2 mutation and poor prognosis in IDH-WT adult glioblastoma patients, and identifies a specific subpopulation of high-grade glioma-associated microglia (HGG-AM) with pro-inflammatory and proliferative characteristics that interact with tumor cells to promote progression. The depletion of TGF-beta 1/TbRI significantly reduces HGG-AM density and suppresses tumor growth.

CELL REPORTS (2021)

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Article Oncology

Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

Laura M. Richards et al.

Summary: The study revealed that glioblastomas contain diverse cell populations, with GSCs showing high transcriptional heterogeneity associated with normal neural development and inflammatory wound response. Genome-wide CRISPR-Cas9 dropout screens validated this observation. Additionally, the majority of malignant cells were found to organize along an orthogonal astrocyte maturation gradient while retaining founder GSC transcriptional programs.

NATURE CANCER (2021)

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Article Medicine, Research & Experimental

Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells

Hila Shaim et al.

Summary: Glioblastoma stem cells (GSCs) in the aggressive brain cancer Glioblastoma multiforme (GBM) evade immune responses by impairing the function of tumor-infiltrating NK cells through a direct cell-to-cell contact mechanism mediated by alpha v integrin and TGF-β activation. Treatment with inhibitors of integrin or TGF-β signaling, or with TGFBR2 gene-edited allogeneic NK cells, prevents GSC-induced NK cell dysfunction and tumor growth, suggesting a potential therapeutic strategy for GBM.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Oncology

Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities

Luciano Garofano et al.

Summary: Garofano et al. classified glioblastomas into subtypes along metabolic and neurodevelopmental axes using single-cell RNA-sequencing data. Mitochondrial GBM showed the most favorable clinical outcome and vulnerability to inhibitors of oxidative phosphorylation, while glycolytic/plurimetabolic GBM relied on aerobic glycolysis and other metabolic pathways for energy production. This pathway-based classification can inform survival and precision targeting of cancer metabolism.

NATURE CANCER (2021)

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Article Biochemistry & Molecular Biology

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

Fadi Jacob et al.

CELL (2020)

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Article Cell & Tissue Engineering

Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma

Aparna Bhaduri et al.

CELL STEM CELL (2020)

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Article Biochemistry & Molecular Biology

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

Sangeeta Goswami et al.

NATURE MEDICINE (2020)

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Review Oncology

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Sue Han et al.

BRITISH JOURNAL OF CANCER (2020)

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The Glioma Stem Cell Model in the Era of Single-Cell Genomics

Mario L. Suva et al.

CANCER CELL (2020)

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Myeloid-Derived Suppressor Cell Subsets Drive Glioblastoma Growth in a Sex-Specific Manner

Defne Bayik et al.

CANCER DISCOVERY (2020)

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Article Multidisciplinary Sciences

Genomic copy number variation correlates with survival outcomes in WHO grade IV glioma

Zachary S. Buchwald et al.

SCIENTIFIC REPORTS (2020)

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Article Multidisciplinary Sciences

Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies

Kai Yu et al.

NATIONAL SCIENCE REVIEW (2020)

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Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment

Anaelle A. Dumas et al.

EMBO JOURNAL (2020)

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Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

Ashley Maynard et al.

CELL (2020)

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Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

Charles P. Couturier et al.

NATURE COMMUNICATIONS (2020)

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Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy

Lisa M. Ebert et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

Kurt A. Schalper et al.

NATURE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Timothy F. Cloughesy et al.

NATURE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

Junfei Zhao et al.

NATURE MEDICINE (2019)

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Article Immunology

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

Rapolas Zilionis et al.

IMMUNITY (2019)

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Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma

Stephen C. Mack et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

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NATURE IMMUNOLOGY (2019)

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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Maisa C. Takenaka et al.

NATURE NEUROSCIENCE (2019)

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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Hannah Van Hove et al.

NATURE NEUROSCIENCE (2019)

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Review Genetics & Heredity

Single-Cell RNA-Seq Technologies and Related Computational Data Analysis

Geng Chen et al.

FRONTIERS IN GENETICS (2019)

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Article Oncology

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

Peiwen Chen et al.

CANCER CELL (2019)

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An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

Cyril Neftel et al.

CELL (2019)

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Review Biochemistry & Molecular Biology

Current best practices in single-cell RNA-seq analysis: a tutorial

Malte D. Luecken et al.

MOLECULAR SYSTEMS BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Clonal replacement of tumor-specific T cells following PD-1 blockade

Kathryn E. Yost et al.

NATURE MEDICINE (2019)

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The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation

Lin Wang et al.

CANCER DISCOVERY (2019)

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Stalled developmental programs at the root of pediatric brain tumors

Selin Jessa et al.

NATURE GENETICS (2019)

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Genomic analysis of primary and recurrent gliomas reveals clinical outcome related molecular features

Longbo Zhang et al.

SCIENTIFIC REPORTS (2019)

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Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

Timothy R. Hammond et al.

IMMUNITY (2019)

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Article Oncology

Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells

Amelia Weber Hall et al.

CANCER RESEARCH (2018)

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DNA methylation-based classification of central nervous system tumours

David Capper et al.

NATURE (2018)

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Myeloid-derived suppressor cells coming of age

Filippo Veglia et al.

NATURE IMMUNOLOGY (2018)

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Review Oncology

Current state of immunotherapy for glioblastoma

Michael Lim et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Multidisciplinary Sciences

An anatomic transcriptional atlas of human glioblastoma

Ralph B. Puchalski et al.

SCIENCE (2018)

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Article Genetics & Heredity

Single-cell transcriptome analysis of lineage diversity in high-grade glioma

Jinzhou Yuan et al.

GENOME MEDICINE (2018)

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Article Oncology

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

Michael Weller et al.

LANCET ONCOLOGY (2017)

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Article Multidisciplinary Sciences

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

Xiaoyang Lan et al.

NATURE (2017)

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Article Genetics & Heredity

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Jin-Ku Lee et al.

NATURE GENETICS (2017)

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Article Biochemical Research Methods

Simultaneous epitope and transcriptome measurement in single cells

Marlon Stoeckius et al.

NATURE METHODS (2017)

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Article Oncology

Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas

Khalil Abou-El-Ardat et al.

NEURO-ONCOLOGY (2017)

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Article Cell Biology

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

Spyros Darmanis et al.

CELL REPORTS (2017)

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Article Biotechnology & Applied Microbiology

Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment

Soren Muller et al.

GENOME BIOLOGY (2017)

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Article Oncology

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Qianghu Wang et al.

CANCER CELL (2017)

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Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity

Elanor N. Wainwright et al.

TRENDS IN CANCER (2017)

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CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients

Daniel Dubinski et al.

NEURO-ONCOLOGY (2016)

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Article Biochemistry & Molecular Biology

Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas

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Increase in Both CD14-Positive and CD15-Positive Myeloid-Derived Suppressor Cell Subpopulations in the Blood of Patients With Glioma But Predominance of CD15-Positive Myeloid-Derived Suppressor Cells in Glioma Tissue

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Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

Mona Meyer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Glioblastoma: Defining Tumor Niches

Dolores Hambardzumyan et al.

TRENDS IN CANCER (2015)

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Article Biochemistry & Molecular Biology

Glioma cell-derived placental growth factor induces regulatory B cells

Song Han et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

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Article Oncology

Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry

Anh N. Tran et al.

NEURO-ONCOLOGY (2014)

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Article Multidisciplinary Sciences

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Anoop P. Patel et al.

SCIENCE (2014)

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Review Immunology

Ontogeny of myeloid cells

Isme De Kleer et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Article Biochemistry & Molecular Biology

The Somatic Genomic Landscape of Glioblastoma

Cameron W. Brennan et al.

CELL (2013)

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Article Multidisciplinary Sciences

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

Andrea Sottoriva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Oncology

Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy

Courtney A. Crane et al.

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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

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Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas

Y. Komohara et al.

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Shideng Bao et al.

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Article Oncology

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

HS Phillips et al.

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The metastasis associated protein S100A4: role in tumour progression and metastasis

DM Helfman et al.

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MGMT gene silencing and benefit from temozolomide in glioblastoma

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