4.1 Article

Human CD4+CD25+CD127lowFOXP3+ regulatory T lymphocytes and CD4+CD25-FOXP3- conventional T lymphocytes: a differential transcriptome profile

期刊

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 42, 期 11, 页码 919-929

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2023.2216226

关键词

Regulatory T cells; conventional T cells; transcriptional profile

向作者/读者索取更多资源

CD4(+)CD25(+) FOXP3(+) regulatory T cells are important in suppressing immune reactions, but difficult to distinguish from conventional CD4(+) T cells. This study identifies differentially transcribed genes between Tregs and conventional T cells using qRT-PCR and bioinformatics analysis, providing new molecular targets for understanding Tregs' function and isolation.
CD4(+)CD25(+) FOXP3(+) regulatory T cells (Tregs) represent a subpopulation of CD4(+) T cells central for the suppression of physiological and pathological immune reactions. Although distinct cell surface antigens are expressed in regulatory T cells, those components are also present on the surface of activated CD4(+)CD25(-) FOXP3(-)T cells, thus making the discrimination between Tregs and conventional CD4(+) T difficult and isolation of Tregs complex. Yet, the molecular components driving Tregs' function are still not fully characterized. Aiming at unraveling molecular components specifically marking Tregs, and upon using quantitative real-time PCR (qRT-PCR) followed by bioinformatics analysis, we identified, in this study, differential transcriptional profiles, in peripheral blood CD4 + CD25 + CD127(low) FOXP3+ Tregs versus CD4 + CD25-FOXP3- conventional T cells, for set of genes with distinct immunological roles. In conclusion, this study identifies some novel genes that appeared to be differentially transcribed in CD4+ Tregs versus conventional T cells. The identified genes could serve as novel molecular targets relevant to Tregs' function and isolation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据