相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Interface refinement of low- to medium-resolution Cryo-EM complexes using HADDOCK2.4
Tim Neijenhuis et al.
STRUCTURE (2022)
Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway
Benjamin M. Stinson et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021 (2021)
Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis
Robin Oz et al.
NUCLEIC ACIDS RESEARCH (2021)
Mechanisms restraining break-induced replication at two-ended DNA double-strand breaks
Nhung Pham et al.
EMBO JOURNAL (2021)
The Multifaceted Roles of Ku70/80
Sayma Zahid et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Structural basis of long-range to short-range synaptic transition in NHEJ
Siyu Chen et al.
NATURE (2021)
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
Amanda K. Chaplin et al.
MOLECULAR CELL (2021)
Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes
Erika Casari et al.
NATURE COMMUNICATIONS (2021)
Structural biology of multicomponent assemblies in DNA double-strand-break repair through non-homologous end joining
Amanda K. Chaplin et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)
ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
Sebastien Britton et al.
NUCLEIC ACIDS RESEARCH (2020)
Can Predicted Protein 3D Structures Provide Reliable Insights into whether Missense Variants Are Disease Associated?
Sirawit Ittisoponpisan et al.
JOURNAL OF MOLECULAR BIOLOGY (2019)
The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
Bailin Zhao et al.
NATURE COMMUNICATIONS (2019)
Dissection of DNA double-strand-break repair using novel single-molecule forceps
Jing L. Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance
Corinne Cassani et al.
NUCLEIC ACIDS RESEARCH (2018)
Dissection of DNA double-strand-break repair using novel single-molecule forceps
Jing L. Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Mre11 complex links sister chromatids to promote repair of a collapsed replication fork
Min Zhu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection
Tai-Yuan Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability
Julyun Oh et al.
CELL REPORTS (2018)
Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstacles
Weibin Wang et al.
GENES & DEVELOPMENT (2017)
Physiological protein blocks direct the Mre11-Rad50-Xrs2 and Sae2 nuclease complex to initiate DNA end resection
Giordano Reginato et al.
GENES & DEVELOPMENT (2017)
Coupling end resection with the checkpoint response at DNA double-strand breaks
Matteo Villa et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency
Howard H. Y. Chang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes
G. C. P. van Zundert et al.
JOURNAL OF MOLECULAR BIOLOGY (2016)
Two-Stage Synapsis of DNA Ends during Non-homologous End Joining
Thomas G. W. Graham et al.
MOLECULAR CELL (2016)
Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection
Roopesh Anand et al.
MOLECULAR CELL (2016)
Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks
Corinne Cassani et al.
PLOS BIOLOGY (2016)
The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation
Daichi Iwasaki et al.
PLOS GENETICS (2016)
Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly
Xuan Li et al.
ELIFE (2016)
Synthetic viability genomic screening defines Sae2 function in DNA repair
Fabio Puddu et al.
EMBO JOURNAL (2015)
Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection
Diego Bonetti et al.
EMBO REPORTS (2015)
Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair
Dylan A. Reid et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity
Elisa Gobbini et al.
PLOS GENETICS (2015)
Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break
Matteo Ferrari et al.
PLOS GENETICS (2015)
The Principal Role of Ku in Telomere Length Maintenance Is Promotion of Est1 Association with Telomeres
Jaime M. Williams et al.
GENETICS (2014)
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Atsushi Shibata et al.
MOLECULAR CELL (2014)
Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks
Elda Cannavo et al.
NATURE (2014)
Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair
Anuja Mehta et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
Sebastien Britton et al.
JOURNAL OF CELL BIOLOGY (2013)
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
G. Madhavi Sastry et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres
Albert Ribes-Zamora et al.
CELL REPORTS (2013)
The Ku Heterodimer and the Metabolism of Single-Ended DNA Double-Strand Breaks
Alessia Balestrini et al.
CELL REPORTS (2013)
Coincident Resection at Both Ends of Random, γ-Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease
James W. Westmoreland et al.
PLOS GENETICS (2013)
Chromosome integrity at a double-strand break requires exonuclease 1 and MRX
Wataru Nakai et al.
DNA REPAIR (2011)
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
Amitabh V. Nimonkar et al.
GENES & DEVELOPMENT (2011)
Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage
Steven S. Foster et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1
Valerie Garcia et al.
NATURE (2011)
Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks
Petra Langerak et al.
PLOS GENETICS (2011)
Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
Eleni P. Mimitou et al.
EMBO JOURNAL (2010)
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
Eun Yong Shim et al.
EMBO JOURNAL (2010)
Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex
Michal Hammel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae
Hengyao Niu et al.
NATURE (2010)
DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2
Petr Cejka et al.
NATURE (2010)
Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair
Marco Saponaro et al.
PLOS GENETICS (2010)
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
Zhu Zhu et al.
CELL (2008)
Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
Christian Zierhut et al.
EMBO JOURNAL (2008)
Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
Isabelle Morin et al.
EMBO JOURNAL (2008)
The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle
Michela Clerici et al.
EMBO REPORTS (2008)
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
Eleni P. Mimitou et al.
NATURE (2008)
Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations
Kihoon Lee et al.
NATURE (2008)
CDK targets Sae2 to control DNA-end resection and homologous recombination
Pablo Huertas et al.
NATURE (2008)
Heterochromatin is refractory to γ-H2AX modification in yeast and mammals
Jung-Ae Kim et al.
JOURNAL OF CELL BIOLOGY (2007)
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
Elijahu Berkovich et al.
NATURE CELL BIOLOGY (2007)
Loading of the nonhomologous end joining factor, Ku, on protein-occluded DNA ends
Steven A. Roberts et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions
Albert Ribes-Zamora et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
2-Step purification of the Ku DNA repair protein expressed in Escherichia coli
Les A. Hanakahi
PROTEIN EXPRESSION AND PURIFICATION (2007)
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs
Angel Rivera-Calzada et al.
EMBO REPORTS (2007)
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair
Laura Spagnolo et al.
MOLECULAR CELL (2006)
The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling
M Clerici et al.
EMBO REPORTS (2006)
The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends
M Clerici et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae
T Tsukuda et al.
NATURE (2005)
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
ZS You et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Protein production by auto-induction in high-density shaking cultures
FW Studier
PROTEIN EXPRESSION AND PURIFICATION (2005)
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
J Falck et al.
NATURE (2005)
A hierarchical approach to all-atom protein loop prediction
MP Jacobson et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)
A means to a DNA end: The many roles of Ku
JA Downs et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
M Lisby et al.
CELL (2004)
DNA breaks promote genomic instability by impeding proper chromosome segregation
JA Kaye et al.
CURRENT BIOLOGY (2004)
Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex
K Lobachev et al.
CURRENT BIOLOGY (2004)
The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle
Y Aylon et al.
EMBO JOURNAL (2004)
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
G Ira et al.
NATURE (2004)
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break
R Shroff et al.
CURRENT BIOLOGY (2004)
The role of DNA dependent protein kinase in synapsis of DNA ends
E Weterings et al.
NUCLEIC ACIDS RESEARCH (2003)
The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini
AA Bertuch et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism
D Nakada et al.
GENES & DEVELOPMENT (2003)
Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres
K Tomita et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase
MB Vaze et al.
MOLECULAR CELL (2002)
Synapsis of DNA ends by DNA-dependent protein kinase
LG DeFazio et al.
EMBO JOURNAL (2002)
NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway
M Frank-Vaillant et al.
GENES & DEVELOPMENT (2001)
Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast
A Kegel et al.
CURRENT BIOLOGY (2001)
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
JR Walker et al.
NATURE (2001)
Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system
L Aravind et al.
GENOME RESEARCH (2001)
A DNA damage response pathway controlled by Tel1 and the Mre11 complex
T Usui et al.
MOLECULAR CELL (2001)
Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase
JC Mallory et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
分享论文
