期刊
NUCLEIC ACIDS RESEARCH
卷 51, 期 W1, 页码 W213-W224出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkad399
关键词
-
GeneRanger is a web server that integrates data from multiple atlases to provide information about gene and protein expression in normal human cells, tissues, and cell lines. TargetRanger, on the other hand, compares uploaded RNA-seq data to expression levels across atlases to identify highly expressed genes in the input that are lowly expressed in normal human cells and tissues. Both servers offer visualization through box and scatter plots, as well as interactive tables.
Several atlasing efforts aim to profile human gene and protein expression across tissues, cell types and cell lines in normal physiology, development and disease. One utility of these resources is to examine the expression of a single gene across all cell types, tissues and cell lines in each atlas. However, there is currently no centralized place that integrates data from several atlases to provide this type of data in a uniform format for visualization, analysis and download, and via an application programming interface. To address this need, GeneRanger is a web server that provides access to processed data about gene and protein expression across normal human cell types, tissues and cell lines from several atlases. At the same time, TargetRanger is a related web server that takes as input RNA-seq data from profiled human cells and tissues, and then compares the uploaded input data to expression levels across the atlases to identify genes that are highly expressed in the input and lowly expressed across normal hu-man cell types and tissues. Identified targets can be filtered by transmembrane or secreted proteins. The results from GeneRanger and TargetRanger are visualized as box and scatter plots, and as interactive tables. GeneRanger and TargetRanger are available from https://generanger.maayanlab.cloud and https://targetranger.maayanlab.cloud, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据