Assessment of the sensitivity of 2H MR spectroscopy measurements of [2,3-2H2]fumarate metabolism for detecting tumor cell death

Article Radiology, Nuclear Medicine & Medical Imaging

Deuterium MRSI of tumor cell death in vivo following oral delivery of 2H-labeled fumarate

Friederike Hesse et al.

Summary: This study showed that orally administered labeled fumarate can be used to detect tumor cell death noninvasively following treatment with a sensitivity similar to that obtained with intravenous administration.

MAGNETIC RESONANCE IN MEDICINE (2022)

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Article Neurosciences

Deuterium metabolic imaging and hyperpolarized 13C-MRI of the normal human brain at clinical field strength reveals differential cerebral metabolism

Joshua Kaggie et al.

Summary: Deuterium metabolic imaging (DMI) and hyperpolarized C-13-pyruvate MRI (C-13-HPMRI) are two emerging non-invasive imaging methods that can probe both oxidative and non-oxidative metabolism. This study directly compares these two methods in humans for the first time, showing that they provide different yet complementary readouts of metabolism.

NEUROIMAGE (2022)

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Article Multidisciplinary Sciences

Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging

Friederike Hesse et al.

Summary: H-2 magnetic resonance spectroscopic imaging is a viable technique for metabolic imaging in the clinic, and measurements of labeled malate production from fumarate can be used to detect tumor cell death in vivo. The increase in malate/fumarate ratio after drug treatment correlates with increased levels of cell death in tumors.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Biochemical Research Methods