Seizure Rescue Therapies: Comparing Approved and Commonly Used Benzodiazepine Formulations

Acute seizure therapies given out of the hospital are important for interrupting acute repetitive and prolonged seizures and preventing hospitalization. These vary in their administration routes, indications for children and adults, pharmacologic profiles, and efficacy. We reviewed and compared the uses of current formulations available to treat acute seizures, including newly released intranasal (IN) benzodiazepines and older formulations which are widely used for interrupting seizures.

Automated summary

Acute seizure therapies given out of the hospital play a crucial role in interrupting acute repetitive and prolonged seizures and avoiding hospitalization. The administration routes, indications for different age groups, pharmacologic profiles, and efficacy of these therapies vary. We conducted a review and comparison of current formulations used to treat acute seizures, including newly released intranasal benzodiazepines and older formulations commonly used to interrupt seizures.