4.6 Article

Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

Kevin C. Johnson et al.

Summary: Single-cell DNA methylation and transcriptomic glioma analyses reveal the association between local DNA methylation disorder and cellular plasticity, with implications for disease progression and therapeutic response shaping. Glioma cells exhibit increased DNA methylation disorder under environmental stress, highlighting an epigenetically facilitated adaptive stress response process.

NATURE GENETICS (2021)

Article Multidisciplinary Sciences

Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Aaminah Khan et al.

Summary: DIPG is a deadly childhood brain tumor with limited treatment options. Targeting both polyamine synthesis and uptake can lead to prolonged survival in animal models of this incurable disease.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma

Jason Miska et al.

Summary: The survival of tumor-associated myeloid cells in glioblastoma is supported by upregulation of the arginine-ornithine-polyamine axis, which buffers low intracellular pH. This promotes immunosuppression and tumor evolution, and can be targeted for therapeutic benefit.

SCIENCE ADVANCES (2021)

Review Oncology

Polyamine metabolism and cancer: treatments, challenges and opportunities

Robert A. Casero et al.

NATURE REVIEWS CANCER (2018)

Review Cell Biology

The Emerging Hallmarks of Cancer Metabolism

Natalya N. Pavlova et al.

CELL METABOLISM (2016)

Editorial Material Oncology

The current state of cancer metabolism FOREWORD

Rob A. Cairns et al.

NATURE REVIEWS CANCER (2016)

Article Multidisciplinary Sciences

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Anoop P. Patel et al.

SCIENCE (2014)

Article Oncology

Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment

Candace S. Hayes et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Editorial Material Oncology

Polyamine blockade promotes antitumor immunity

Candace S. Hayes et al.

ONCOIMMUNOLOGY (2014)

Article Clinical Neurology

Microdialysis applications in neuroscience

Gi Ja Lee et al.

NEUROLOGICAL RESEARCH (2008)

Review Oncology

Polyamines and cancer: Old molecules, new understanding

EW Gerner et al.

NATURE REVIEWS CANCER (2004)

Article Biochemistry & Molecular Biology

Glutamate release promotes growth of malignant gliomas

T Takano et al.

NATURE MEDICINE (2001)