Neural correlates of neuroticism: A coordinate-based meta-analysis of resting-state functional brain imaging studies

Neuroticism is one of the most robust higher-order personality traits associated with negative emotionality and risk of mental disorders. Many studies have investigated relationships between neuroticism and the brain, but the results have been inconsistent. We conducted a meta-analysis of whole-brain resting-state functional neuroimaging studies to identify the most stable neurofunctional substrates of neuroticism. We found stable significant positive correlations between neuroticism and resting-state brain activity in the left middle temporal gyrus (MTG), left striatum, and right hippocampus. In contrast, resting-state brain activity in the left superior temporal gyrus (STG) and right supramarginal gyrus (SMG) was negatively associated with neuroticism. Additionally, meta-regression analysis revealed brain regions in which sex and age moderated the link of spontaneous activity with neuroticism. This is the first study to provide a comprehensive understanding of resting-state brain activity correlates of neuroticism, and the findings may be useful for the targeting of specific brain regions for interventions to decrease the risks of mental health problems.

Automated summary

A meta-analysis of resting-state functional neuroimaging studies showed that neuroticism is positively correlated with brain activity in the left middle temporal gyrus, left striatum, and right hippocampus, but negatively correlated with brain activity in the left superior temporal gyrus and right supramarginal gyrus. Sex and age were found to moderate the link between spontaneous brain activity and neuroticism.