Outcomes in Patients With COVID-19 With Acute Encephalopathy and Coma An International Prospective Study

Editorial Material Medicine, General & Internal

Transcranial direct current stimulation associated with pharmacological approaches in patients infected by SARS-CoV-2

Edson Silva-Filho et al.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2023)

Article Critical Care Medicine

Disorders of Consciousness in Hospitalized Patients with COVID-19: The Role of the Systemic Inflammatory Response Syndrome

Amelia K. Boehme et al.

Summary: The prevalence and etiology of unconsciousness in hospitalized patients with severe COVID-19 are uncertain. Increased inflammation in COVID-19 may precede coma, and is associated with higher mortality and longer hospital stays.

NEUROCRITICAL CARE (2022)

添加到收藏夹

Article Critical Care Medicine

Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC

Konstantinos Dimitriadis et al.

Summary: This study characterized the prevalence, risk factors, and impact on outcome of neurologic manifestations in critically ill COVID-19 patients. The findings showed that neurologic disorders increased mortality and morbidity in these patients. The neurologic manifestations may be indirect sequelae of the infection or severe critical illness.

CRITICAL CARE (2022)

添加到收藏夹

Article Clinical Neurology

A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City

Jennifer A. Frontera et al.

Summary: This study found that 13.5% of COVID-19 patients developed new neurologic disorders, which were associated with increased risk of in-hospital mortality and decreased likelihood of discharge home.

NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Neurological complications of COVID-19 in hospitalized patients: The registry of a neurology department in the first wave of the pandemic

Sofia Portela-Sanchez et al.

Summary: This study described the spectrum of neurological complications in COVID-19 patients requiring a neurological assessment, with only 2.6% of hospitalized patients experiencing at least one complication. The most common diagnoses were neuromuscular disorders, cerebrovascular diseases, acute encephalopathy, and seizures. Mortality was higher in the cerebrovascular diseases group.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

添加到收藏夹

Review Clinical Neurology

Presentations and mechanisms of CNS disorders related to COVID-19

Marta Bodro et al.

Summary: Patients with COVID-19 may experience a variety of central nervous system complications, including activation of inflammatory and thrombotic pathways, as well as direct viral effects in some cases. Critically ill patients may develop cognitive dysfunction in the setting of septic encephalopathy, likely due to multifactorial mechanisms.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

添加到收藏夹

Article Neurosciences

Reversible Cerebral Vasoconstriction Syndrome in Patients with Coronavirus Disease: A Multicenter Case Series

Kristine Arandela et al.

Summary: This study describes the clinical features, risk factors, and outcomes of RCVS in a group of COVID-19 patients. The findings suggest that COVID-19 patients may be at risk for developing RCVS, especially with additional risk factors such as exposure to vasoactive agents. There was variability in symptoms and severity of COVID-19, clinical characteristics, imaging abnormalities, and mRS scores among the patients with RCVS.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

添加到收藏夹

Article Clinical Neurology

Acute Ischemic Stroke and COVID-19 An Analysis of 27 676 Patients

Adnan Qureshi et al.

Summary: Acute ischemic stroke is rare in patients with COVID-19 and is usually accompanied by other cardiovascular risk factors. The risk of discharge to a destination other than home or death doubles with the occurrence of acute ischemic stroke in patients with COVID-19.

STROKE (2021)

添加到收藏夹

Review Behavioral Sciences

Status epilepticus and COVID-19: A systematic review

Fedele Dono et al.

Summary: SE is a neurological manifestation of SARS-CoV-2 infection, with age, time between acute respiratory phase of infection and SE onset, and hospitalization correlating with SE severity. The exact mechanisms linking SE and COVID-19 are not fully understood, but systemic inflammatory syndrome due to cytokine release may play a role.

EPILEPSY & BEHAVIOR (2021)

添加到收藏夹

Article Clinical Neurology

Neurological update: COVID-19

A. L. Ren et al.

Summary: COVID-19 is primarily a respiratory disease, but can also lead to neurological complications. The main processes causing neurological damage include cerebrovascular disease, immunologically mediated neurological disorders, and the harmful effects of critical illness on the nervous system. While it is still uncertain if the virus directly invades the nervous system, the large number of infections at present suggests that nervous system infection may not be a significant issue.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Critical Care Medicine

Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19

Jennifer A. Frontera et al.

Summary: This study revealed that the prevalence of TME in COVID-19 patients was approximately 12%, mainly caused by hypoxemia, sepsis, and uremia. Patients with TME had a higher mortality rate compared to those without TME, with the highest risk seen in TME due to hypoxemia.

NEUROCRITICAL CARE (2021)

添加到收藏夹

Editorial Material Psychiatry

How COVID-19 Affects the Brain

Maura Boldrini et al.

JAMA PSYCHIATRY (2021)

添加到收藏夹

Article Medicine, General & Internal

Trends in Patient Characteristics and COVID-19 In-Hospital Mortality in the United States During the COVID-19 Pandemic

Gregory A. Roth et al.

Summary: In this retrospective cohort study involving 20,736 adults with COVID-19 in the United States, in-hospital mortality rates decreased after March and April and remained at a lower level from May through November, regardless of changes in patient characteristics.

JAMA NETWORK OPEN (2021)

添加到收藏夹

Article Medicine, General & Internal

Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium

Sherry H. -Y. Chou et al.

Summary: This study included patients with clinically diagnosed or laboratory-confirmed COVID-19 at 28 centers across 13 countries and 4 continents from March 1 to September 30, 2020. Neurological manifestations were prevalent among hospitalized patients with COVID-19 and were associated with higher in-hospital mortality. Patients with preexisting neurological disorders were at increased risk of developing neurological signs and/or syndromes in COVID-19.

JAMA NETWORK OPEN (2021)

添加到收藏夹

Review Clinical Neurology

Posterior Reversible Encephalopathy Syndrome and brain haemorrhage as COVID-19 complication: a review of the available literature

Francesco Motolese et al.

Summary: COVID-19 patients with PRES presenting with brain hemorrhage may be associated with coagulopathy and endothelial dysfunction, emphasizing the importance of timely diagnosis and intervention.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Psychiatry

6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records

Maxime Taquet et al.

Summary: Our study provides evidence of significant neurological and psychiatric morbidity in the 6 months following COVID-19 infection. The risks were highest in patients with severe COVID-19. This information could assist in service planning and research priority identification.

LANCET PSYCHIATRY (2021)

添加到收藏夹

Article Infectious Diseases

Neurologic manifestations associated with COVID-19: a multicentre registry

Elodie Meppiel et al.

Summary: This study provides an overview of neurologic manifestations associated with SARS-CoV-2 infection in 222 COVID-19 patients during the French COVID-19 epidemic in 2020. The results showed a wide range of neurologic diseases and a high short-term mortality rate.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

添加到收藏夹

Article Critical Care Medicine

Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study

Matthieu Schmidt et al.

Summary: Among more than 4000 critically ill patients with COVID-19 admitted to our ICUs, 90-day mortality was 31% and decreased from 42 to 25% over the study period. Mortality was higher in older, diabetic, obese and severe ARDS patients.

INTENSIVE CARE MEDICINE (2021)

添加到收藏夹

Editorial Material Critical Care Medicine