期刊
NEUROIMAGE
卷 269, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2023.119911
关键词
Resting-state fMRI; Multiscale brain functional network; Functional brain age; Harmonization; Tangent space parameterization; Brain age gap
In this study, a brain age prediction model of multiscale functional connectivity measures was built using a large fMRI dataset. The study found that multiscale functional connectivity measures were more informative than single-scale measures for brain age prediction. Data harmonization significantly improved the predictive performance, and harmonization in the tangent space of functional connectivity measures worked better than in their original space. Additionally, the brain age gap derived from the prediction model was significantly correlated with clinical and cognitive measures.
To learn multiscale functional connectivity patterns of the aging brain, we built a brain age prediction model of functional connectivity measures at seven scales on a large fMRI dataset, consisting of resting-state fMRI scans of 4186 individuals with a wide age range (22 to 97 years, with an average of 63) from five cohorts. We computed multiscale functional connectivity measures of individual subjects using a personalized functional network com-putational method, harmonized the functional connectivity measures of subjects from multiple datasets in order to build a functional brain age model, and finally evaluated how functional brain age gap correlated with cog-nitive measures of individual subjects. Our study has revealed that functional connectivity measures at multiple scales were more informative than those at any single scale for the brain age prediction, the data harmonization significantly improved the brain age prediction performance, and the data harmonization in the functional con-nectivity measures' tangent space worked better than in their original space. Moreover, brain age gap scores of individual subjects derived from the brain age prediction model were significantly correlated with clinical and cognitive measures. Overall, these results demonstrated that multiscale functional connectivity patterns learned from a large-scale multi-site rsfMRI dataset were informative for characterizing the aging brain and the derived brain age gap was associated with cognitive and clinical measures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据