Isoflurane rapidly modifies synaptic and cytoskeletal phosphoproteomes of the supraoptic nucleus of the hypothalamus and the cortex

Article Biochemical Research Methods

Translational and Posttranslational Dynamics in a Model Peptidergic System

Soledad Bárez-López et al.

MOLECULAR & CELLULAR PROTEOMICS (2023)

Review Neurosciences

Neural Substrates for the Regulation of Sleep and General Anesthesia

Qianzi Yang et al.

Summary: This article provides a review of the latest evidence on the neural substrates for sleep and general anesthesia regulation by comparing the roles of pivotal nuclei in sleep and anesthesia.

CURRENT NEUROPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum

Pol Andres-Benito et al.

Summary: This study focuses on the significance of host tau in tau seeding and spreading, as well as the molecular changes associated with the transformation of host tau into abnormal tau. The findings show that host tau is necessary for tau seeding and spreading following inoculation with sarkosyl-insoluble tau fractions from AD brains. The study also reveals that tau seeding is accompanied by genotype-dependent tau phosphorylation, tau nitration, MAP2 phosphorylation, and activation of specific kinases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Endocrinology & Metabolism

Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2

Soledad Barez-Lopez et al.

Summary: This study explores the expression of two genes, Caprin2 and Creb3l1, in magnocellular neurones (MCNs) and their changes during dehydration. The findings suggest that both genes are expressed in MCNs and their expression increases in response to dehydration. Protein levels mirror the increase in transcript levels for both CREB3L1 and CAPRIN2. In addition, CREB3L1 may be a transcription factor regulating Oxt gene expression, while CAPRIN2 binds to Oxt mRNA and regulates its poly(A) tail length.

NEUROENDOCRINOLOGY (2022)

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Article Biochemistry & Molecular Biology

Short-Term Administration of Common Anesthetics Does Not Dramatically Change the Endogenous Peptide Profile in the Rat Pituitary

Somayeh Mousavi et al.

Summary: Cell-cell signaling peptides play important roles in various physiological processes, and liquid chromatography-mass spectrometry-based peptidomics workflows are commonly used to identify and quantify their relative abundances. However, acute administration of anesthetics may affect the measured abundance of cell-cell signaling peptides, especially in the brain and endocrine system. This study evaluated the effect of short-term anesthetic administration on the measured abundance of these peptides and found that isoflurane had a minor impact on the levels of some peptides, while sodium pentobarbital had negligible impact.

ACS CHEMICAL NEUROSCIENCE (2022)

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Review Multidisciplinary Sciences

Magnetic field effects in biology from the perspective of the radical pair mechanism

Hadi Zadeh-Haghighi et al.

Summary: This article reviews the impact of weak magnetic fields on biological systems and proposes an explanation based on the radical pair mechanism. By studying static, hypomagnetic, and oscillating magnetic fields, as well as isotope effects, it is found that magnetosensitivity is widespread throughout biology.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2022)

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Article Cell Biology

Pax3 inhibits Neuro-2a cells proliferation and neurite outgrowth

Bingqing Huo et al.

Summary: Pax3 inhibits cell viability and proliferation, affects cell cycle and neurite outgrowth in Neuro-2a cells; Pax7 overexpression has no significant impact on cell viability and proliferation; Pax3 up-regulated genes are involved in cell cycle machinery, potentially revealing the mechanism of Neuro-2a cell proliferation.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Aquaporin 1 mediates early responses to osmotic stimuli in endothelial cells via the calmodulin pathway

Yong Jiang et al.

Summary: The study found that AQP1 responds to osmotic stimuli by redistributing to the cell membrane and influencing changes in cell size. Exposure to hypo- or hypertonic medium can induce alterations in cell volume, and calmodulin kinase appears to regulate AQP1 activity during the early response phase.

FEBS OPEN BIO (2021)

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Article Biochemistry & Molecular Biology

MAP2 is differentially phosphorylated in schizophrenia, altering its function

M. J. Grubisha et al.

Summary: Schizophrenia is a highly polygenic disorder where phosphorylation alters the function of MAP2, leading to impairments in neuronal structure and synaptic protein synthesis.

MOLECULAR PSYCHIATRY (2021)

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Article Multidisciplinary Sciences

Prolonged anesthesia alters brain synaptic architecture

Michael Wenzel et al.

Summary: Prolonged medically induced coma (pMIC) is routinely carried out in intensive care medicine, leading to cognitive impairment. A study on adolescent and mature mice shows that pMIC affects object recognition and is associated with enhanced synaptic turnover, with increased synapse formation during pMIC and synaptic loss post-anesthesia. These results demonstrate significant side effects of prolonged anesthesia on neural circuit structure.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Biochemistry & Molecular Biology

Sensorimotor Perturbation Induces Late and Transient Molecular Synaptic Proteins Activation and Expression Changes

Julie Fourneau et al.

Summary: This study investigated the synaptic plasticity process in the somatosensory primary cortex during a period of sensorimotor perturbation and recovery. The results showed that changes in the presynaptic compartment occurred as early as D7 during SMP, followed by changes in the postsynaptic compartment at D14, and these changes persisted at least until 24 hours of recovery. Proteins related to synapse structure were mildly affected, primarily at D14.

JOURNAL OF MOLECULAR NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Radical pairs may play a role in xenon-induced general anesthesia

Jordan Smith et al.

Summary: This study investigates the xenon-induced general anesthesia process and suggests that the potency of xenon as a general anesthetic is influenced by isotopic dependence. They propose a mechanism where xenon nuclear spin may affect the recombination dynamics of radical pairs of electrons. Their model is able to reproduce the observed isotopic dependence in the potency of xenon as a general anesthetic, supporting the idea that radical pairs of electrons with entangled spins could play a role in consciousness.

SCIENTIFIC REPORTS (2021)

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Article Clinical Neurology

Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer's disease

Isidro Ferrer et al.

Summary: The study found abnormal protein phosphorylation at the early stages of NFT pathology in the elderly and sporadic Alzheimer's disease (sAD), with protein phosphorylation abnormalities in the FC preceding the formation of NFTs and SPs. The most active period of dysregulated phosphorylation is at stages III-IV, when some individuals may be classified clinically as having mild cognitive impairment, which is a precursor stage in the progression to dementia.

BRAIN PATHOLOGY (2021)

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Review Anatomy & Morphology

Dendritic spine remodeling and plasticity under general anesthesia

Simon Granak et al.

Summary: General anesthesia, considered a medical miracle, enables life-saving interventions without pain sensation and traumatic memories. However, the mechanisms of how it induces a coma-like state are not fully understood. Research shows that even brief exposure to general anesthesia can have lasting effects on brain plasticity, cognition, mood, and social behavior.

BRAIN STRUCTURE & FUNCTION (2021)

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Review Endocrinology & Metabolism

The multiple faces of the oxytocin and vasopressin systems in the brain

Valery Grinevich et al.

Summary: Traditionally, hypothalamic neuroendocrine cells were classified into magnocellular and parvocellular neurons for hormone release and brain circuit regulation purposes respectively. However, recent studies show these classic projections are outdated, with oxytocin and vasopressin released in the brain from dendrites and distant axon varicosities to modulate information transfer through conventional synapses.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

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Article Neurosciences

Anesthesia in mice activates discrete populations of neurons throughout the brain

Shai-Lee Yatziv et al.

Summary: The brain undergoes rapid, dramatic, and reversible transitions between wakefulness and unconsciousness during sleep and in pathological conditions. Selective transitioning allows for the persistence of basic functions while mobility, sensory perception, memory formation, and awareness are lost. The role of specific brainstem and diencephalic arousal nuclei in driving these transitions has been implicated.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

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Review Mathematical & Computational Biology

Post-translational modifications in proteins: resources, tools and prediction methods

Shahin Ramazi et al.

Summary: Posttranslational modifications (PTMs) involve modifications to amino acid side chains in proteins after biosynthesis, affecting various aspects of protein functions. Disruptions in PTMs can lead to diseases, emphasizing the need for computational methods to predict PTMs. High-throughput experimental methods for PTM discovery are laborious, prompting the exploration of computational tools and databases to advance research in this area.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2021)

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Article Cell Biology

Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway

Xiao-Ling Wang et al.

AGING-US (2020)

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Article Behavioral Sciences

Voluntary wheel running during adolescence distinctly alters running output in adulthood in male and female rats

Dvijen C. Purohit et al.

BEHAVIOURAL BRAIN RESEARCH (2020)

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Article Multidisciplinary Sciences

Studies on the mechanism of general anesthesia

Mahmud Arif Pavel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Anesthesiology

Lasting effects of general anesthetics on the brain in the young and elderly: mixed picture of neurotoxicity, neuroprotection and cognitive impairment

Lingzhi Wu et al.

JOURNAL OF ANESTHESIA (2019)

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Article Neurosciences

A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep

Li-Feng Jiang-Xie et al.

NEURON (2019)

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Article Biochemistry & Molecular Biology

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

Uku Raudvere et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Neurosciences

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Frank Koopmans et al.

NEURON (2019)

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Article Endocrinology & Metabolism

Influence of perioperative stress on central and peripheral oxytocin and arginine-vasopressin concentrations

Simone Maria Kagerbauer et al.

JOURNAL OF NEUROENDOCRINOLOGY (2019)

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Article Multidisciplinary Sciences

Sleep-wake cycles drive daily dynamics of synaptic phosphorylation

Franziska Bruening et al.

SCIENCE (2019)

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Review Cell Biology

Microtubule-Asssociated Proteins: Structuring the Cytoskeleton

Satish Bodakuntla et al.

TRENDS IN CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

The PRIDE database and related tools and resources in 2019: improving support for quantification data

Yasset Perez-Riverol et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Anesthesiology

Nuclear Spin Attenuates the Anesthetic Potency of Xenon Isotopes in Mice: Implications for the Mechanisms of Anesthesia and Consciousness

Na Li et al.

ANESTHESIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Synaptic protein changes after a chronic period of sensorimotor perturbation in adult rats: a potential role of phosphorylation/O-GlcNAcylation interplay

Julie Fourneau et al.

JOURNAL OF NEUROCHEMISTRY (2018)

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Article Multidisciplinary Sciences

General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels

Jun-ichi Kishikawa et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations

Aurelie Tomczak et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need

Zhiqiang Wang et al.

NATURE (2018)

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Article Neurosciences

Anesthetic Isoflurane Induces DNA Damage Through Oxidative Stress and p53 Pathway

Cheng Ni et al.

MOLECULAR NEUROBIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Brief Isoflurane Anesthesia Produces Prominent Phosphoproteomic Changes in the Adult Mouse Hippocampus

Samuel Kohtala et al.

ACS CHEMICAL NEUROSCIENCE (2016)

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Article Multidisciplinary Sciences

Phosphoproteome Profiling of SH-SY5y Neuroblastoma Cells Treated with Anesthetics: Sevoflurane and Isoflurane Affect the Phosphorylation of Proteins Involved in Cytoskeletal Regulation

Joomin Lee et al.

PLOS ONE (2016)

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Review Neurosciences

Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking

Carlos Wilson et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

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Article Neurosciences

Transcription Factor CREB3L1 Regulates Vasopressin Gene Expression in the Rat Hypothalamus

Mingkwan Greenwood et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Neurosciences

Phosphorylation of Synapsin I by Cyclin-Dependent Kinase-5 Sets the Ratio between the Resting and Recycling Pools of Synaptic Vesicles at Hippocampal Synapses

Anne M. J. Verstegen et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Multidisciplinary Sciences

Functionally Enigmatic Genes: A Case Study of the Brain Ignorome

Ashutosh K. Pandey et al.

PLOS ONE (2014)

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Article Neurosciences

JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination

Emilia Komulainen et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

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Article Anesthesiology

Proteomic profiling of the phosphoproteins in the rat thalamus, hippocampus and frontal lobe after propofol anesthesia

Jing Tang et al.

BMC ANESTHESIOLOGY (2014)

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Article Cell Biology

Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection

Steven J. Coultrap et al.

CELL REPORTS (2014)

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Animal research: Reporting in vivo experiments: The ARRIVE guidelines

Carol Kilkenny et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

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Review Biochemistry & Molecular Biology

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

C. -X. Gong et al.

CURRENT MEDICINAL CHEMISTRY (2008)

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Article Neurosciences

Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep

Vladyslav V. Vyazovskiy et al.

NATURE NEUROSCIENCE (2008)

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Review Neurosciences

General anaesthesia: From molecular targets to neuronal pathways of sleep and arousal

Nicholas P. Franks

NATURE REVIEWS NEUROSCIENCE (2008)

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Article Biochemical Research Methods

Halothane binding proteome in human brain cortex

Jonathan Z. Pan et al.

JOURNAL OF PROTEOME RESEARCH (2007)

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Article Surgery

Effects of different anesthetic techniques on antidiuretic hormone secretion during laparoscopic cholecystectomy

M. A. M. Youssef et al.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2007)

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Article Cell Biology

Glycogen synthase kinase-3β phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons

N Trivedi et al.

JOURNAL OF CELL SCIENCE (2005)

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Article Biochemistry & Molecular Biology

Inhalational anesthetic-binding proteins in rat neuronal membranes

J Xi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies

P Chi et al.

NEURON (2003)

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Review Physiology

Gene regulation in the magnocellular hypothalamo-neurohypophysial system

JPH Burbach et al.

PHYSIOLOGICAL REVIEWS (2001)

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Isoflurane rapidly modifies synaptic and cytoskeletal phosphoproteomes of the supraoptic nucleus of the hypothalamus and the cortex

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