☆ 4.5 Review

Biomarkers: Role and Scope in Neurological Disorders

NEUROCHEMICAL RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair

Jacinta N. Conroy et al.

Summary: Neurotrophin signaling is crucial for normal nervous system development and function. Understanding the mechanism of high-affinity receptor generation will facilitate the development of pharmaceuticals for the treatment of nervous system disorders. Despite decades of research, the modulation mechanism of the high-affinity complex remains unclear.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

A Glimpse of Molecular Biomarkers in Huntington's Disease

Silvia Marti-Martinez et al.

Summary: Huntington's disease is a neurodegenerative disorder caused by abnormal expansion of CAG repeats in the Huntingtin gene. It not only affects the central nervous system but also has a peripheral component. Precise diagnosis and evaluation of therapeutic response require the use of biomarkers with prognostic value.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Neurosciences

Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice

Nicholas S. Caron et al.

Summary: Huntington's disease is a neurodegenerative disease caused by a trinucleotide repeat expansion in the HTT gene. Therapies that lower mutant huntingtin (mHTT) in the central nervous system (CNS) have shown promise, and quantitation of mHTT in the cerebrospinal fluid (CSF) is being used as a biomarker. This study demonstrates that the striatum contributes significantly to CSF mHTT and suggests that CSF mHTT may be a biomarker for therapies targeting mHTT in the striatum.

NEUROBIOLOGY OF DISEASE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lamp1 Deficiency Enhances Sensitivity to α-Synuclein and Oxidative Stress in Drosophila Models of Parkinson Disease

Zohra Rahmani et al.

Summary: The lack of Lamp1 in fruit flies increases susceptibility to oxidative stress and neurotoxicity caused by alpha-synuclein, suggesting a protective role of Lamp1 in Parkinson's disease models. Lamp1 promotes the formation of non-pathogenic aggregates, neutralizing the toxicity of alpha-synuclein.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Clinical Neurology

Urinary kynurenine as a biomarker for Parkinson's disease

Jia-he Bai et al.

Summary: The study found that urine kynurenine (KYN) levels were significantly higher in early-stage Parkinson's disease (PD) patients compared to healthy controls. Urine KYN levels were significantly associated with PD severity and mild cognitive impairment. Urine KYN may serve as a new biomarker for early-stage PD.

NEUROLOGICAL SCIENCES (2021)

添加到收藏夹

Review Neurosciences

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

Ceren Eyileten et al.

Summary: BDNF plays a crucial role in nervous system development and the pathogenesis of neurodegenerative diseases, while miRNAs may serve as potential biomarkers and therapeutic targets.

MOLECULAR NEUROBIOLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal Fluid Levels of Prodynorphin-Derived Peptides Are Decreased in Huntington's Disease

M. H. D. Rami Al Shweiki et al.

Summary: PDYN-derived peptides were found to be substantially decreased in the CSF of HD patients, while NfL levels were elevated, indicating that PDYN-derived peptides may be a more specific biomarker for HD.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease

Juhee Kang et al.

Summary: The study identified potential plasma biomarkers for early diagnosis of Parkinson's disease (PD) in 20 PD patients and 20 essential tremor patients, with BAG2 and cathepsin D showing decreased levels in PD plasma samples. These biomarkers were able to distinguish PD with 87.5% diagnostic accuracy.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Circulating tRNA Fragments as a Novel Biomarker Class to Distinguish Acute Stroke Subtypes

T. Truc My Nguyen et al.

Summary: This study found that tRNA-derived fragments can serve as promising novel biomarkers to distinguish between acute IS, ICH, SM, and healthy controls.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Immunology

Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke

Juan Marta-Enguita et al.

Summary: Plasma calprotectin is an independent predictor of 3-month mortality after AIS and provides complementary prognostic information. The presence of S100A9 in stroke thrombi suggests an inflammatory mechanism in clot formation, with higher levels correlating with poorer outcomes. Further studies are needed to determine the influence of S100A9 in resistance to reperfusion.

JOURNAL OF NEUROINFLAMMATION (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules

Xian Jiang et al.

Summary: The study revealed that interference with microtubules or actin filaments, JNKs, PKA, or AKT signaling pathways can affect heterologous synapse formation, with JNK and PKA inhibitors suppressing both pre- and postsynaptic specialization formation, while AKT inhibitors only impairing postsynaptic specialization formation. By targeting PTEN, an enzyme regulating AKT activation, to postsynaptic sites, a decrease in excitatory synapse function was observed, indicating a multifaceted and multistage kinase network underlying heterologous synapse formation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Psychiatry

Serum d-serine levels are altered in early phases of Alzheimer's disease: towards a precocious biomarker

Luciano Piubelli et al.

Summary: This study investigated the levels of d-amino acids in the serum of Alzheimer's disease (AD) patients and healthy subjects, and found that the serum d-serine level and d-/total serine ratio can serve as novel biomarkers for the progression of AD.

TRANSLATIONAL PSYCHIATRY (2021)

添加到收藏夹

Article Clinical Neurology

TDP-43 as structure-based biomarker in amyotrophic lateral sclerosis

Leon Beyer et al.

Summary: The study shows that measuring the misfolding of TDP-43 in the cerebrospinal fluid of ALS patients using immuno-infrared sensor technology has the potential to serve as a biomarker for ALS. The technology can accurately distinguish ALS patients from other control groups.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Decreased serum creatinine levels predict short survival in amyotrophic lateral sclerosis

Qi-Fu Guo et al.

Summary: Serum creatinine is a reliable prognostic marker for ALS, with lower levels predicting poor prognosis and shorter survival in both male and female patients. Serum creatinine levels are positively correlated with ALSFRS-R scores and inversely correlated with the decline rate of ALSFRS-R per month. Additionally, higher decline rates of creatinine per month are associated with significantly shorter survival during the disease progression.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

添加到收藏夹

Review Cell Biology

microRNAs as Early Biomarkers of Alzheimer's Disease: A Synaptic Perspective

Dolores Siedlecki-Wullich et al.

Summary: miRNAs have emerged as promising biomarkers for early detection of synaptic dysfunction in AD and can distinguish between prodromal AD and healthy controls. Further validation studies and standardized protocols are needed for establishing miRNA-based biomarkers as reliable diagnostic and prognostic tools.

CELLS (2021)

添加到收藏夹

Article Medicine, General & Internal

Comparison between Ischemic and Hemorrhagic Strokes in Functional Outcome at Discharge from an Intensive Rehabilitation Hospital

Emilia Salvadori et al.

Summary: Comparison studies on recovery outcomes in ischemic (IS) and hemorrhagic strokes (HS) have shown mixed results. In a retrospective observational study, it was found that HS patients were younger and had more severe clinical deficits compared to IS patients. However, functional status change at discharge did not significantly differ between the two stroke types, with age and initial stroke severity being main prognostic factors.

DIAGNOSTICS (2021)

添加到收藏夹

Article Oncology

Plasma contact factors as novel biomarkers for diagnosing Alzheimer's disease

Jung Eun Park et al.

Summary: This study identified new plasma biomarkers for accurate diagnosis of AD by investigating the relationship between the plasma contact system and AD. The activity of contact factors, especially FXIIa, were found to increase as AD progresses, with specific cut-off scores established for different stages of the disease. These findings suggest that FXIIa activity and the CSF A beta(1-42)/FXIIa ratio can serve as novel and accurate diagnostic biomarkers for AD.

BIOMARKER RESEARCH (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction in Alzheimer's Disease: A Biomarker of the Future?

Simon M. Bell et al.

Summary: Alzheimer's disease is the most common cause of dementia globally, characterized by amyloid beta and tau protein accumulation with currently no approved treatment. In addition to protein aggregation, other pathological changes and early alterations in mitochondrial function are present. Mitochondrial dysfunction caused by amyloid and tau may serve as potential biomarkers for early detection of AD, but further research with larger patient cohorts is needed for clinical application.

BIOMEDICINES (2021)

添加到收藏夹

Article Clinical Neurology

Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology

Nicholas J. Ashton et al.

Summary: Plasma phosphorylated tau231 is a promising biomarker for detecting Alzheimer's disease, accurately distinguishing AD patients from others and showing potential for early detection of pathology. Its performance is strong across various disease settings and it correlates well with other indicators of AD progression.

ACTA NEUROPATHOLOGICA (2021)

添加到收藏夹

Review Medical Laboratory Technology

The trends in nanomaterial-based biosensors for detecting critical biomarkers in stroke

Sanam Dolati et al.

Summary: Acute ischemic stroke is the second leading cause of death globally, with challenging diagnosis and a lack of rapid diagnostic tests. Biomarker-based diagnostic approaches have shown significant value in stroke management. The review focuses on summarizing optical and electrochemical biosensors for detecting critical biomarkers in stroke.

CLINICA CHIMICA ACTA (2021)

添加到收藏夹

Article Clinical Neurology

Tau protein as a diagnostic and prognostic biomarker in amyotrophic lateral sclerosis

Luisa Agnello et al.

Summary: The study demonstrated that tTau and pTau/tTau ratio in the cerebrospinal fluid could serve as diagnostic biomarkers for ALS, with tTau level at diagnosis playing a significant prognostic role in the disease's progression.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

What, When and How to Measure-Peripheral Biomarkers in Therapy of Huntington's Disease

Lukasz Przybyl et al.

Summary: Developing therapeutic strategies for HD requires the development of biomarkers for assessing treatment efficacy, with symptoms in peripheral tissues serving as indicators. Investigation of inflammatory proteins and immune cells in HD can provide insights into disease pathogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Novel targeted therapies for Parkinson's disease

Theodora Ntetsika et al.

Summary: Parkinson's disease is the second most common neurodegenerative disease globally, with treatment options currently limited to symptom relief without halting or reversing disease progression. Large biomarker development programs are being carried out to improve patient selection and clinical trial outcome assessment. Research on Parkinson's disease mechanisms and ongoing clinical trials are crucial for future perspectives in the field.

MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Nutrition & Dietetics

Gut microbiota-derived metabolite trimethylamine N-oxide as a biomarker in early Parkinson's disease

Seok Jong Chung et al.

Summary: This study found that lower baseline plasma TMAO levels are associated with faster increases in LED and tend to increase the risk for PD-dementia conversion, suggesting the prognostic implications of TMAO in early stage PD.

NUTRITION (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington's disease

Zhen-Yi Andy Ou et al.

Summary: This study found that BDNF concentration in plasma and cerebrospinal fluid is unlikely to be a biomarker for Huntington's disease progression, and caution is needed when interpreting studies using conventional ELISA to quantify BDNF.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Bone-Derived Factors as Potential Biomarkers for Parkinson's Disease

Yuwan Lin et al.

Summary: Plasma levels of OCN and OPN in PD patients are correlated with inflammation response, disease stage, and motor impairment, making them potential biomarkers for PD. The combination of plasma assessment and CSF detection enhances predictive ability for PD.

FRONTIERS IN AGING NEUROSCIENCE (2021)

添加到收藏夹

Article Mathematical & Computational Biology

X-Vectors: New Quantitative Biomarkers for Early Parkinson's Disease Detection From Speech

Laetitia Jeancolas et al.

Summary: This study used the latest x-vectors technology for early detection of Parkinson's disease, finding better classification performance in women for early PD detection compared to the traditional MFCC-GMM method.

FRONTIERS IN NEUROINFORMATICS (2021)

添加到收藏夹

Article Neurosciences

Ecto-GPR37: a potential biomarker for Parkinson's disease

Xavier Morato et al.

Summary: The study shows that the expression of GPR37 is increased in the substantia nigra of sporadic PD patients, and elevated levels of ecto-GPR37 peptides were detected in the cerebrospinal fluid of PD patients.

TRANSLATIONAL NEURODEGENERATION (2021)

添加到收藏夹

Review Neurosciences

Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: Current Evidence and Future Perspectives

Donovan A. McGrowder et al.

Summary: This review presents the current evidence on CSF biomarkers for Alzheimer's disease, emphasizing the efficacy of existing core biomarkers and the need for further development of biomarkers reflecting other aspects of the disease mechanism. It also introduces new biomarkers that track Alzheimer's disease pathology and their potential in diagnosis and predicting cognitive decline.

BRAIN SCIENCES (2021)

添加到收藏夹

Review Medicine, General & Internal

Diagnostics of Amyotrophic Lateral Sclerosis: Up to Date

Ivana Stetkarova et al.

Summary: ALS is a progressive neurodegenerative disease that typically does not affect eye and sphincter muscles. The cause of the disease is still unknown, but prompt diagnosis and proper management play a crucial role in prolonging survival.

DIAGNOSTICS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics

Arvin Behzadi et al.

Summary: Elevated levels of CSF NFL, CSF pNFH, and plasma NFL are significantly associated with ALS, providing diagnostic value in differentiating ALS from other neurological diseases. Plasma NFL levels can help differentiate between clinical and genetic subgroups of ALS. Survival rate is negatively correlated with all three biomarkers.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Clinical Neurology

Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease

Jan Rusz et al.

Summary: This multilanguage study utilized simple speech recording and high-end pattern analysis to provide sensitive and reliable noninvasive biomarkers for patients with iRBD and early-stage PD. Significant abnormalities in speech severity measures were found in both iRBD and PD groups, with distinctions in certain speech characteristics observed between the two groups. This automated speech analysis may serve as a useful additional biomarker for assessing disease progression and therapeutic interventions in parkinsonism.

ANNALS OF NEUROLOGY (2021)

添加到收藏夹

Editorial Material Neurosciences

Synaptic dysfunction in amyotrophic lateral sclerosis/frontotemporal dementia: Therapeutic strategies and novel biomarkers

Karthik Krishnamurthy et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

添加到收藏夹

Article Clinical Neurology

Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31

Danielle A. Simmons et al.

Summary: This study investigates the use of multimodal MRI and plasma cytokines as potential pharmacodynamic biomarkers for Huntington's disease treatment. Results show that the small molecule p75(NTR) ligand LM11A-31 can alleviate volume reductions in brain regions, normalize DTI metrics, and diminish plasma cytokine levels in an HD mouse model. These findings suggest that a combination of MRI and plasma cytokine levels could be effective biomarkers for assessing treatment efficacy in clinical trials.

NEUROTHERAPEUTICS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Salivary caffeine in Parkinson's disease

Giorgio Leodori et al.

Summary: The study revealed that salivary caffeine levels in Parkinson's disease (PD) patients were associated with disease severity, duration, and motor complications. While early and de-novo PD patients showed normal caffeine levels, those with moderate/advanced PD had decreased levels. However, caffeine absorption and metabolism were normal in PD patients.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease

Paola Gamba et al.

Summary: This review discusses the controversial role of 24-OHC in AD pathogenesis, including its levels in different AD biological samples and its detrimental or neuroprotective effects in the brain.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Neurosciences

Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations

Sukriti Vishwas et al.

Summary: Huntington's disease is a genetic disease with limited treatment options, herbal drugs offer a potential alternative with better safety profile, but their limited solubility and permeability has hindered clinical exploration. Research focus has shifted towards developing herbal drug-based nanoformulations to enhance their efficacy.

CURRENT NEUROPHARMACOLOGY (2021)

添加到收藏夹

Article Neurosciences

Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease

Szilvia Vas et al.

Summary: Sleep disruption is a common but often overlooked symptom of neurological dysfunction in Huntington's disease (HD). In a study using transgenic sheep as a presymptomatic model of HD, researchers found early alterations in sleep-wake patterns and EEG powers. The findings suggest that transgenic sheep may exist in a chronic state resembling physiological sleep deprivation, which could contribute to deficits in neurological function associated with the onset of HD.

NEUROBIOLOGY OF DISEASE (2021)

添加到收藏夹

Article Clinical Neurology

Transactivation response DNA-binding protein of 43 kDa proteinopathy and lysosomal abnormalities in spastic paraplegia type 11

Shinichiro Mori et al.

Summary: SPG11 is a common hereditary spastic paraplegia characterized by spastic paraplegia, cognitive impairment, dementia, and parkinsonism. Neuropathological analysis reveals neurodegeneration and unique SQSTM1-positive neuronal inclusions, suggesting a causal connection between TDP-43 proteinopathy and autophagy dysfunction in SPG11.

NEUROPATHOLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Teaching an old dog new tricks: serum troponin T as a biomarker in amyotrophic lateral sclerosis

Sergio Castro-Gomez et al.

Summary: The study found that serum cardiac troponin T is elevated in over 60% of amyotrophic lateral sclerosis patients, while cardiac troponin I remains normal. Levels of serum cardiac troponin T increase over time and correlate with disease severity. It is suggested that the elevation of cardiac troponin T in ALS patients may indicate lower motor neuron or skeletal muscle involvement and could potentially assist in patient stratification.

BRAIN COMMUNICATIONS (2021)

添加到收藏夹

Article Medicine, General & Internal

Serum S100β as a predictor of severity and outcomes for mixed subtype acute ischaemic stroke

Siwat Sakdejayont et al.

SINGAPORE MEDICAL JOURNAL (2020)

添加到收藏夹

Article Neurosciences

Neurofilament Light Chain as a Biomarker, and Correlation with Magnetic Resonance Imaging in Diagnosis of CNS-Related Disorders

Zahra Alirezaei et al.

MOLECULAR NEUROBIOLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases

Tomoya Kon et al.

NEUROPATHOLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Blood biomarkers with Parkinson's disease clusters and prognosis: the oxford discovery cohort

Michael Lawton et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases

Fabiana Novellino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis

Metka Ravnik-Glavac et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Cell Biology

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

Diana C. Munoz-Lasso et al.

CELLS (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Modeling Parkinson's Disease With the Alpha-Synuclein Protein

Monica Gomez-Benito et al.

FRONTIERS IN PHARMACOLOGY (2020)

添加到收藏夹

Review Psychiatry

Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality

Maria Salud Garcia-Gutierrez et al.

FRONTIERS IN PSYCHIATRY (2020)

添加到收藏夹

Review Neurosciences

Functional Near-Infrared Spectroscopy and Its Clinical Application in the Field of Neuroscience: Advances and Future Directions

Wei-Liang Chen et al.

FRONTIERS IN NEUROSCIENCE (2020)

添加到收藏夹

Review Neurosciences

Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers

Elisabetta Zucchi et al.

MOLECULAR NEURODEGENERATION (2020)

添加到收藏夹

Review Clinical Neurology

Association of Matrix Metalloproteinase 9 and Cellular Fibronectin and Outcome in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Lu Wang et al.

FRONTIERS IN NEUROLOGY (2020)

添加到收藏夹

Review Clinical Neurology

Pathophysiology of Blood-Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery

Sara Bernardo-Castro et al.

FRONTIERS IN NEUROLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Predictive value of inflammatory markers for functional outcomes in patients with ischemic stroke

Fariborz Rezaeitalab et al.

CURRENT JOURNAL OF NEUROLOGY (2020)

添加到收藏夹

Review Neurosciences

Blood-based molecular biomarkers for Alzheimer's disease

Henrik Zetterberg et al.

MOLECULAR BRAIN (2019)

添加到收藏夹

Review Neurosciences

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

Archana Prasad et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

添加到收藏夹

Review Biochemical Research Methods

The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in development

Filippo Baldacci et al.

EXPERT REVIEW OF PROTEOMICS (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Immunomodulatory Therapeutic Strategies in Stroke

Kyle Malone et al.

FRONTIERS IN PHARMACOLOGY (2019)

添加到收藏夹

Review Immunology

The anatomy and immunology of vasculature in the central nervous system

Panagiotis Mastorakos et al.

SCIENCE IMMUNOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Diagnostic and Prognostic Role of Blood and Cerebrospinal Fluid and Blood Neurofilaments in Amyotrophic Lateral Sclerosis: A Review of the Literature

Delia Gagliardi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cytokines in Inflammatory Disease

Shinwan Kany et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Does nesfatin-1 influence the hypothalamic-pituitary-gonadal axis in adult males with obstructive sleep apnoea?

Halina Batura-Gabryel et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Biochemical Research Methods

Quantitative Proteomic Profiling of Cerebrospinal Fluid to Identify Candidate Biomarkers for Alzheimer's Disease

Gajanan Sathe et al.

PROTEOMICS CLINICAL APPLICATIONS (2019)

添加到收藏夹

Review Clinical Neurology

Diagnostic and Prognostic Performance of Neurofilaments in ALS

Koen Poesen et al.

FRONTIERS IN NEUROLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values

S. Kuldeep Dhama et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Biomarker definitions and their applications

Robert M. Califf

EXPERIMENTAL BIOLOGY AND MEDICINE (2018)

添加到收藏夹

Review Immunology

Inflammation in CNS neurodegenerative diseases

Jodie Stephenson et al.

IMMUNOLOGY (2018)

添加到收藏夹

Review Medicine, Research & Experimental

In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation

Bastian Zinnhardt et al.

THERANOSTICS (2018)

添加到收藏夹

Article Neurosciences

Glio- and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37

Beihui Liu et al.

GLIA (2018)

添加到收藏夹

Review Clinical Neurology

Diagnostic biomarkers for Parkinson's disease at a glance: where are we?

Ilaria Cova et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin

Yuichiro Mita et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Clinical Neurology

Novel Imaging Biomarkers for Huntington's Disease and Other Hereditary Choreas

Patrik Fazio et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2018)

添加到收藏夹

Review Nutrition & Dietetics

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

Manuel H. Janeiro et al.

NUTRIENTS (2018)

添加到收藏夹

Review Geriatrics & Gerontology

Recent Advances in Biomarkers for Parkinson's Disease

Runcheng He et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

添加到收藏夹

Article Neurosciences

Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson's disease

Amy K. Reeve et al.

NPJ PARKINSONS DISEASE (2018)

添加到收藏夹

Review Neurosciences

Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches

Rashad Hussain et al.

BRAIN SCIENCES (2018)

添加到收藏夹

Review Oncology

Tau in neurodegenerative disease

Yong-Lei Gao et al.

ANNALS OF TRANSLATIONAL MEDICINE (2018)

添加到收藏夹

Review Peripheral Vascular Disease

Stroke in the 21st Century: A Snapshot of the Burden, Epidemiology, and Quality of Life

Eric S. Donkor

STROKE RESEARCH AND TREATMENT (2018)

添加到收藏夹

Review Medical Laboratory Technology

Application of Cardiac Troponin in Cardiovascular Diseases Other Than Acute Coronary Syndrome

Kai M. Eggers et al.

CLINICAL CHEMISTRY (2017)

添加到收藏夹

Article Clinical Neurology

The Association of Musculoskeletal Pain with Bone Mineral Density in Patients with Parkinson's Disease

Seong-Min Choi et al.

EUROPEAN NEUROLOGY (2017)

添加到收藏夹

Article Clinical Neurology

Association between increased N-terminal pro-brain natriuretic peptide level and poor clinical outcomes after acute ischemic stroke

Jingyuan yang et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

添加到收藏夹

Review Genetics & Heredity

Maximum inspiratory pressure as a clinically meaningful trial endpoint for neuromuscular diseases: a comprehensive review of the literature

Benedikt Schoser et al.

ORPHANET JOURNAL OF RARE DISEASES (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells

Andre Uitterdijk et al.

PLOS ONE (2017)

添加到收藏夹

Review Neurosciences

Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?

Weidong Le et al.

NEUROSCIENCE BULLETIN (2017)

添加到收藏夹

Review Clinical Neurology

Molecular imaging Markers to Track Huntington's Disease Pathology

Heather Wilson et al.

FRONTIERS IN NEUROLOGY (2017)

添加到收藏夹

Review Clinical Neurology

Alzheimer's Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid

Rose Ann Huynh et al.

FRONTIERS IN NEUROLOGY (2017)

添加到收藏夹

Review Clinical Neurology

Vascular, glial, and lymphatic immune gateways of the central nervous system

Britta Engelhardt et al.

ACTA NEUROPATHOLOGICA (2016)

添加到收藏夹

Article Clinical Neurology

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

Bruno Dubois et al.

ALZHEIMERS & DEMENTIA (2016)

添加到收藏夹

Article Immunology

Potential biomarkers to follow the progression and treatment response of Huntington's disease

Marie-Helene Disatnik et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

添加到收藏夹

Review Cell Biology

Neuroimmunology of Huntington's Disease: Revisiting Evidence from Human Studies

Natalia P. Rocha et al.

MEDIATORS OF INFLAMMATION (2016)

添加到收藏夹

Article Clinical Neurology

Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease

Naveed Malek et al.

MOVEMENT DISORDERS (2016)

添加到收藏夹

Review Clinical Neurology

Inflammation and Stroke: An Overview

Josef Anrather et al.

NEUROTHERAPEUTICS (2016)

添加到收藏夹

Article Clinical Neurology

Stages of the Inflammatory Response in Pathology and Tissue Repair after Intracerebral Hemorrhage

Michael H. Askenase et al.

SEMINARS IN NEUROLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination

Hyun-Jeong Yang et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Association between S100B Levels and Long-Term Outcome after Aneurysmal Subarachnoid Hemorrhage: Systematic Review and Pooled Analysis

Pui Man Rosalind Lai et al.

PLOS ONE (2016)

添加到收藏夹

Review Neurosciences

Cerebrospinal Fluid Biomarkers for Huntington's Disease

Lauren M. Byrne et al.

JOURNAL OF HUNTINGTONS DISEASE (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Predictive biomarkers for treatment selection: statistical considerations

James J. Chen et al.

BIOMARKERS IN MEDICINE (2015)

添加到收藏夹

Review Clinical Neurology

Evidence for the Importance of Vitamin D Status in Neurologic Conditions

Anusha K. Yeshokumar et al.

CURRENT TREATMENT OPTIONS IN NEUROLOGY (2015)

添加到收藏夹

Article Respiratory System

Diagnostic methods to assess inspiratory and expiratory muscle strength

Pedro Caruso et al.

JORNAL BRASILEIRO DE PNEUMOLOGIA (2015)

添加到收藏夹

Article Endocrinology & Metabolism

Hypothalamic-Pituitary-Adrenal Axis Functioning in Huntington's Disease and its Association with Depressive Symptoms and Suicidality

A. A. M. Hubers et al.

JOURNAL OF NEUROENDOCRINOLOGY (2015)

添加到收藏夹

Review Medicine, Research & Experimental

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

Prasenjit Manna et al.

METABOLIC SYNDROME AND RELATED DISORDERS (2015)

添加到收藏夹

Article Geriatrics & Gerontology

Correlation between decreased CSF α-synuclein and Aβ1-42 in Parkinson disease

Chandana Buddhala et al.

NEUROBIOLOGY OF AGING (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression

Robert Kueffner et al.

NATURE BIOTECHNOLOGY (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Brain Iron Homeostasis: From Molecular Mechanisms To Clinical Significance and Therapeutic Opportunities

Neena Singh et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

添加到收藏夹

Review Clinical Neurology

The role of the posterior cingulate cortex in cognition and disease

Robert Leech et al.

BRAIN (2014)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

Imaging of acute stroke prior to treatment: current practice and evolving techniques

G. Mair et al.

BRITISH JOURNAL OF RADIOLOGY (2014)

添加到收藏夹

Article Neurosciences

Functional magnetic resonance imaging of working memory in Huntington's disease: Cross-sectional data from the IMAGE-HD study

Nellie Georgiou-Karistianis et al.

HUMAN BRAIN MAPPING (2014)

添加到收藏夹

Article Neurosciences

MRI measures of corpus callosum iron and myelin in early Huntington's disease

M. Di Paola et al.

HUMAN BRAIN MAPPING (2014)

添加到收藏夹

Article Neurosciences

Diffusion Weighted Imaging of Prefrontal Cortex in Prodromal Huntington's Disease

Joy T. Matsui et al.

HUMAN BRAIN MAPPING (2014)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Glial Activation in the Early Stages of Brain Metastasis: TSPO as a Diagnostic Biomarker

Emma R. O'Brien et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

添加到收藏夹

Article Neurosciences

Brain Natriuretic Peptide in Acute Ischemic Stroke

Kenji Maruyama et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2014)

添加到收藏夹

Article Clinical Neurology

A Pattern Recognition Approach to Patients with a Suspected Myopathy

Richard J. Barohn et al.

NEUROLOGIC CLINICS (2014)

添加到收藏夹

Letter Clinical Neurology

YKL-40 in cerebrospinal fluid in Huntington's disease - A role in pathology or a nonspecific response to inflammation?

Tua Vinther-Jensen et al.

PARKINSONISM & RELATED DISORDERS (2014)

添加到收藏夹

Article Cell Biology

IL-6 in Inflammation, Immunity, and Disease

Toshio Tanaka et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

添加到收藏夹

Article Clinical Neurology

A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS

Michael E. Bozik et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2014)

添加到收藏夹

Article Clinical Neurology

Amyotrophic Lateral Sclerosis Outcome Measures and the Role of Albumin and Creatinine A Population-Based Study

Adriano Chio et al.

JAMA NEUROLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)

Michaeline L. Hebron et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Pediatrics

Diffusion tensor imaging of normal brain development

Shoko Yoshida et al.

PEDIATRIC RADIOLOGY (2013)

添加到收藏夹

Review Clinical Neurology

Neuroradiological evaluation of demyelinating disease

Jan-Mendelt Tillema et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2013)

添加到收藏夹

Review Clinical Neurology

Microglia activation as a biomarker for traumatic brain injury

Diana G. Hernandez-Ontiveros et al.

FRONTIERS IN NEUROLOGY (2013)

添加到收藏夹

Article Clinical Neurology

Alterations in Brain Transition Metals in Huntington Disease An Evolving and Intricate Story

H. Diana Rosas et al.

ARCHIVES OF NEUROLOGY (2012)

添加到收藏夹

Article Pharmacology & Pharmacy

Roles of cocaine- and amphetamine-regulated transcript in the central nervous system

Meijuan Zhang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2012)

添加到收藏夹

Review Clinical Neurology

How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia: can we learn from other noncoding repeat expansion disorders?

Marka van Blitterswijk et al.

CURRENT OPINION IN NEUROLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Uric acid, hyperuricemia and vascular diseases

Ming Jin et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2012)

添加到收藏夹

Review Oncology

Cancer biomarkers

N. Lynn Henry et al.

MOLECULAR ONCOLOGY (2012)

添加到收藏夹

Article Rehabilitation

Clinical Approach to the Diagnostic Evaluation of Hereditary and Acquired Neuromuscular Diseases

Craig M. McDonald

PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA (2012)

添加到收藏夹

Review Clinical Neurology

Monitoring Huntington's disease progression through preclinical and early stages

Chris Tang et al.

NEURODEGENERATIVE DISEASE MANAGEMENT (2012)

添加到收藏夹

Article Clinical Neurology

Visinin-like Protein-1: Diagnostic and Prognostic Biomarker in Alzheimer Disease

Rawan Tarawneh et al.

ANNALS OF NEUROLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

PET/CT in diagnosis of movement disorders

Valentina Berti et al.

PET/CT APPLICATIONS IN NON-NEOPLASTIC CONDITIONS (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Epigenetic Modifications Basic Mechanisms and Role in Cardiovascular Disease

Diane E. Handy et al.

CIRCULATION (2011)

添加到收藏夹

Review Medical Laboratory Technology

S100B protein in neurodegenerative disorders

Johann Steiner et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2011)

添加到收藏夹

Review Neurosciences

Long-term plasticity at inhibitory synapses

Pablo E. Castillo et al.

CURRENT OPINION IN NEUROBIOLOGY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS

Jeban Ganesalingam et al.

JOURNAL OF NEUROCHEMISTRY (2011)

添加到收藏夹

Review Clinical Neurology

Development of biomarkers for Huntington's disease

David W. Weir et al.

LANCET NEUROLOGY (2011)

添加到收藏夹

Article Clinical Neurology

Neuron-Specific Enolase, S100B, and Glial Fibrillary Acidic Protein Levels as Outcome Predictors in Patients With Severe Traumatic Brain Injury

Ana Elisa Boehmer et al.

NEUROSURGERY (2011)

添加到收藏夹

Article Clinical Neurology

Overview of Functional Magnetic Resonance Imaging

Gary H. Glover

NEUROSURGERY CLINICS OF NORTH AMERICA (2011)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Identifying and validating biomarkers for Alzheimer's disease

Christian Humpel

TRENDS IN BIOTECHNOLOGY (2011)

添加到收藏夹

Review Pharmacology & Pharmacy

Thrombolysis in acute ischaemic stroke: an update

Zahid Zaheer et al.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2011)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Imaging-based treatment selection for intravenous and intra-arterial stroke therapies: a comprehensive review

Albert J. Yoo et al.

EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2011)

添加到收藏夹

Article Clinical Neurology

Clinical Progression in Parkinson Disease and the Neurobiology of Axons

Hsiao-Chun Cheng et al.

ANNALS OF NEUROLOGY (2010)

添加到收藏夹

Review Medicine, Research & Experimental

Cerebrospinal fluid biomarkers of Alzheimer's disease

Anne M. Fagan et al.

BIOMARKERS IN MEDICINE (2010)

添加到收藏夹

Review Clinical Neurology

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

Kaj Blennow et al.

NATURE REVIEWS NEUROLOGY (2010)

添加到收藏夹

Article Clinical Neurology

Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Takashi Kasai et al.

ACTA NEUROPATHOLOGICA (2009)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative Subjects

Leslie M. Shaw et al.

ANNALS OF NEUROLOGY (2009)

添加到收藏夹

Article Medicine, Research & Experimental

Biomarkers in Alzheimer's Disease Not Yet Surrogate Endpoints

N. Coley et al.

BIOMARKERS IN BRAIN DISEASE (2009)

添加到收藏夹

Article Clinical Neurology

Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease

Alberto Ascherio et al.

ARCHIVES OF NEUROLOGY (2009)

添加到收藏夹

Review Medicine, Research & Experimental

Molecular biomarkers in stroke diagnosis and prognosis

Matthew B. Maas et al.

BIOMARKERS IN MEDICINE (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Neuroligins and neurexins link synaptic function to cognitive disease

Thomas C. Sudhof

NATURE (2008)

添加到收藏夹

Review Clinical Neurology

The Lewy body in Parkinson's disease:: Molecules implicated in the formation and degradation of α-synuclein aggregates

Koichi Wakabayashi et al.

NEUROPATHOLOGY (2007)

添加到收藏夹

Article Genetics & Heredity

Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients

A. Ciammola et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

LAMP proteins are required for fusion of lysosomes with phagosomes

Kassidy K. Huynh et al.

EMBO JOURNAL (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Tetsuaki Arai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

添加到收藏夹

Article Medical Laboratory Technology

Identification of novel brain biomarkers

Omar F. Laterza et al.

CLINICAL CHEMISTRY (2006)

添加到收藏夹

Article Clinical Neurology

Diffusion-weighted imaging in Huntington's disease

Klaus Seppi et al.

MOVEMENT DISORDERS (2006)

添加到收藏夹

Article Medical Laboratory Technology

PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke

L Allard et al.

CLINICAL CHEMISTRY (2005)

添加到收藏夹

Review Clinical Neurology

PET imaging of amyloid in Alzheimer's disease

A Nordberg

LANCET NEUROLOGY (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor

D Marazziti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹

Review Cell Biology

Biomarkers of neurodegenerative disorders: How good are they?

V Rachakonda et al.

CELL RESEARCH (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms

EM Hol et al.

MOLECULAR PSYCHIATRY (2003)

添加到收藏夹

Article Clinical Neurology

Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

MJ McGirt et al.

NEUROSURGERY (2002)

添加到收藏夹

Article Biology

The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal

NK Logothetis

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2002)

添加到收藏夹

Review Dentistry, Oral Surgery & Medicine

Osteopontin

J Sodek et al.

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.