4.5 Review

Biomarkers: Role and Scope in Neurological Disorders

期刊

NEUROCHEMICAL RESEARCH
卷 -, 期 -, 页码 -

出版社

SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-023-03873-4

关键词

Biomarker; Huntington's disease; Amyotrophic lateral sclerosis; Stroke; Parkinson's disease; Alzheimer's disease

向作者/读者索取更多资源

Neurological disorders are a significant threat to social health and are responsible for high mortality and morbidity. Although drug development and therapy have improved, inadequate diagnosis and understanding of these disorders have hindered the effectiveness of treatment options. Biomarkers have been seen as a potential solution to the complexities of neurological disorders, providing insight into pathophysiology and guiding therapeutic interventions. However, challenges such as brain complexity, conflicting data, poor diagnostics, and high costs limit biomarker development. Research in this area is crucial for advancing our understanding and treatment of neurological disorders.
Neurological disorders pose a great threat to social health and are a major cause for mortality and morbidity. Effective drug development complemented with the improved drug therapy has made considerable progress towards easing symptoms associated with neurological illnesses, yet poor diagnosis and imprecise understanding of these disorders has led to imperfect treatment options. The scenario is complicated by the inability to extrapolate results of cell culture studies and transgenic models to clinical applications which has stagnated the process of improving drug therapy. In this context, the development of biomarkers has been viewed as beneficial to easing various pathological complications. A biomarker is measured and evaluated in order to gauge the physiological process or a pathological progression of a disease and such a marker can also indicate the clinical or pharmacological response to a therapeutic intervention. The development and identification of biomarkers for neurological disorders involves several issues including the complexity of the brain, unresolved discrepant data from experimental and clinical studies, poor clinical diagnostics, lack of functional endpoints, and high cost and complexity of techniques yet research in the area of biomarkers is highly desired. The present work describes existing biomarkers for various neurological disorders, provides support for the idea that biomarker development may ease our understanding underlying pathophysiology of these disorders and help to design and explore therapeutic targets for effective intervention.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据