A comparison of cognitive performances based on differing rates of DNA methylation GrimAge acceleration among older men and women

Article Psychology, Clinical

Association between depression and epigenetic age acceleration: A co-twin control study

Chang Liu et al.

Summary: This study used a robust co-twin control study design and found an association between depression and DNA methylation age acceleration. The results suggest a potential causal relationship between depression and accelerated aging.

DEPRESSION AND ANXIETY (2022)

添加到收藏夹

Article Clinical Neurology

Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia

Karen Sugden et al.

Summary: This study reveals the association between blood-based DNA methylation algorithms and cognitive impairment and dementia. Different generations of DNA methylation age algorithms have varying degrees of association with cognitive impairment, with the third generation DunedinPACE algorithm showing the strongest correlation in evaluating clinical diagnosis, screening tests, and cognitive tests. A longitudinal analysis in the FHS Offspring Cohort confirms the association between faster pace of aging as measured by DunedinPACE and the risk of developing dementia.

NEUROLOGY (2022)

添加到收藏夹

Review Genetics & Heredity

Epigenetic aging as a biomarker of dementia and related outcomes: a systematic review

Aoshuang Zhou et al.

Summary: There is insufficient evidence to suggest that individuals with dementia experience accelerated biological aging. However, there is some inconsistent evidence linking accelerated aging with poorer cognitive performance.

EPIGENOMICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

An epigenetic predictor of death captures multi-modal measures of brain health

Robert F. Hillary et al.

Summary: The study found that higher DNAm GrimAge is associated with lower cognitive ability and brain vascular lesions in older age, independently of early-life cognitive ability.

MOLECULAR PSYCHIATRY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort

Maxwell L. Elliott et al.

Summary: BrainAGE, a measure of the difference between predicted age from brain-imaging data and chronological age, has been proposed as a biomarker for age-related brain deterioration. Studies suggest that individuals with older brainAGEs may be more susceptible to Alzheimer's, dementia, and mortality, but further research is needed to validate its effectiveness.

MOLECULAR PSYCHIATRY (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Shaping of the Female Human Brain by Sex Hormones: A Review

Elisa Rehbein et al.

Summary: Recent evidence suggests that sex hormones play a significant role in shaping women's brain structure during different hormonal transition periods in their lives, including puberty, menstrual cycle, pregnancy, and menopause. Studies have shown overall reduction in grey matter and region-specific decreases in certain brain areas during these transition periods. Some research also indicates a correlation between brain volume changes and levels of estradiol, testosterone, and progesterone. However, the directionality of this relationship remains inconclusive between studies.

NEUROENDOCRINOLOGY (2021)

添加到收藏夹

Article Anthropology

Epigenetic clocks: Theory and applications in human biology

Calen P. Ryan

Summary: Although all humans age, the process and speed of aging vary greatly from person to person. Epigenetic clocks use changes in the epigenome to estimate chronological age with great accuracy, and deviations between epigenetic age and chronological age are better predictors of health outcomes and mortality risks. Epigenetic clocks capture fundamental molecular processes tied to biological age and are powerful tools for studying health, development, and aging.

AMERICAN JOURNAL OF HUMAN BIOLOGY (2021)

添加到收藏夹

Review Neurosciences

Sex differences in executive control: A systematic review of functional neuroimaging studies

Alexandra Gaillard et al.

Summary: Over the past decade, there has been a significant increase in the number of studies investigating sex differences in executive functions, with evidence suggesting males and females engage different strategies depending on task demands. However, due to methodological variability and the complexity of neural networks involved, a simple overarching statement regarding gender differences during executive control cannot be provided. Sex differences in neural mechanisms are present in the majority of tasks assessed, emphasizing the importance of considering gender in future research.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

添加到收藏夹

Article Geriatrics & Gerontology

GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality

Cathal McCrory et al.

Summary: The study indicates that the GrimAge clock is a significant improvement in predicting age-related decline in various clinical phenotypes compared to other epigenetic clocks, showing better predictive utility and promising to advance precision medicine.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Associations of Age, Sex, Race/Ethnicity, and Education With 13 Epigenetic Clocks in a Nationally Representative US Sample: The Health and Retirement Study

Eileen M. Crimmins et al.

Summary: The study examines the associations between 13 epigenetic clocks and their links to social, demographic, and behavioral factors known to be related to health outcomes. Second generation clocks trained on health-related characteristics tend to have stronger relationships with sociodemographic and health behaviors associated with health outcomes in older adults.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

添加到收藏夹

Article Neurosciences

The Resilience Index: A Quantifiable Measure of Brain Health and Risk of Cognitive Impairment and Dementia

James E. Galvin et al.

Summary: The study introduced the Resilience Index (RI) as a quantifiable measure of brain health, showing that individuals with high RI scores have better cognitive, functional, and behavioral outcomes. The RI could guide clinicians and researchers in developing personalized prevention plans to support brain health.

JOURNAL OF ALZHEIMERS DISEASE (2021)

添加到收藏夹

Article Neurosciences

Characteristics of Epigenetic Clocks Across Blood and Brain Tissue in Older Women and Men

Francine Grodstein et al.

Summary: Epigenetic clocks are valuable biomarkers for aging, especially in understanding brain aging and neurodegenerative diseases. This study compared different epigenetic clocks in blood and brain samples, finding that the Cortical clock showed the highest correlation with chronological age in brain specimens. Further research is needed to explore CpG sites that are conserved across blood and brain for better understanding of neurodegeneration.

FRONTIERS IN NEUROSCIENCE (2021)

添加到收藏夹

Article Psychology, Experimental

Exploring the sex and gender correlates of cognitive sex differences

Sarah Kheloui et al.

Summary: The study aimed to explore the factors influencing cognitive abilities, showing that men outperformed women in mental rotation tasks while no significant difference was found in verbal fluency tasks. Additionally, sex hormones may have a positive impact on cognitive performance in women, and gender roles may have an interactive effect on cognitive abilities.

ACTA PSYCHOLOGICA (2021)

添加到收藏夹

Review Biology

Sex differences in biological aging with a focus on human studies

Sara Hagg et al.

Summary: Aging is a complex biological process with substantial individual variability between men and women. Women generally live longer than men but are frailer at the end of life, while men perform better in physical function examinations. Many age-related diseases exhibit sex-specific patterns.

ELIFE (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Impact of dementia: Health disparities, population trends, care interventions, and economic costs

Maria P. Aranda et al.

Summary: Dementia incidence is decreasing, but the advances in population health are uneven. Studies have identified clear disparities in the educational, geographic, and race/ethnic distribution of Alzheimer's disease and related dementias. Gaps in evidence for interventions may amplify disparities in health and healthcare, while the economic costs for persons living with dementia and their care partners' time are high and may persist into future generations.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

添加到收藏夹

Article Psychology, Developmental

Gender Differences in Cognitive Development in Cohorts of Young, Middle, and Older Adulthood Over 12 Years

Kaarin J. Anstey et al.

Summary: Gender differences in cognitive abilities were stable across different age cohorts, except for faster memory ageing among women in the eighth decade. Additionally, women showed more verbal memory decline between the 8-year and 12-year follow-ups despite having higher average memory performance than men.

DEVELOPMENTAL PSYCHOLOGY (2021)

添加到收藏夹

Review Geriatrics & Gerontology

A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age

Joanne Ryan et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

The Health and Retirement Study Harmonized Cognitive Assessment Protocol Project: Study Design and Methods

Kenneth M. Langa et al.

NEUROEPIDEMIOLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Accelerated epigenetic age and cognitive decline among urban-dwelling adults

May A. Beydoun et al.

NEUROLOGY (2020)

添加到收藏夹

Review Geriatrics & Gerontology

Time for a Systems Biological Approach to Cognitive Aging?-A Critical Review

Deena Ebaid et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

添加到收藏夹

Article Oncology

Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

Robert F. Hillary et al.

CLINICAL EPIGENETICS (2020)

添加到收藏夹

Review Public, Environmental & Occupational Health

What does (low) education mean in terms of dementia risk? A systematic review and meta-analysis highlighting inconsistency in measuring and operationalising education

Janet Maccora et al.

SSM-POPULATION HEALTH (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

An overview of prevalence, determinants and health outcomes of polypharmacy

Mina Khezrian et al.

THERAPEUTIC ADVANCES IN DRUG SAFETY (2020)

添加到收藏夹

Review Clinical Neurology

Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

Yaakov Stern et al.

ALZHEIMERS & DEMENTIA (2020)

添加到收藏夹

Review Neurosciences

Let's call the whole thing off: evaluating gender and sex differences in executive function

Nicola M. Grissom et al.

NEUROPSYCHOPHARMACOLOGY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2019 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2019)

添加到收藏夹

Article Neurosciences

Education Moderates the Relation Between APOE ε4 and Memory in Nondemented Non-Hispanic Black Older Adults

Jet M. J. Vonk et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

添加到收藏夹

Article Cell Biology

DNA methylation GrimAge strongly predicts lifespan and healthspan

Ake T. Lu et al.

AGING-US (2019)

添加到收藏夹

Review Neurosciences

Early-Life Risk Factors for Dementia and Cognitive Impairment in Later Life: A Systematic Review and Meta-Analysis

Xue-Jie Wang et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sex differences in risk factors for vascular contributions to cognitive impairment & dementia

O. J. Gannon et al.

NEUROCHEMISTRY INTERNATIONAL (2019)

添加到收藏夹

Article Gerontology

Trajectories of Normal Cognitive Aging

Timothy A. Salthouse

PSYCHOLOGY AND AGING (2019)

添加到收藏夹

Review Genetics & Heredity

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Steve Horvath et al.

NATURE REVIEWS GENETICS (2018)

添加到收藏夹

Review Clinical Neurology

Imaging Evidence of the Effect of Socio-Economic Status on Brain Structure and Development

Lara Maria Leijser et al.

SEMINARS IN PEDIATRIC NEUROLOGY (2018)

添加到收藏夹

Article Education & Educational Research

DNA methylation signatures of educational attainment

Jenny van Dongen et al.

NPJ SCIENCE OF LEARNING (2018)

添加到收藏夹

Article Geriatrics & Gerontology

DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment

Lara Ianov et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

添加到收藏夹

Review Medicine, General & Internal

Biological Age Predictors

Juulia Jylhava et al.

EBIOMEDICINE (2017)

添加到收藏夹

Article Psychology, Clinical

Age-Related Differences and Heterogeneity in Executive Functions: Analysis of NAB Executive Functions Module Scores

Dorota Buczylowska et al.

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY (2016)

添加到收藏夹

Article Clinical Neurology

Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy

Erin E. Sundermann et al.

NEUROLOGY (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

Steve Horvath et al.

GENOME BIOLOGY (2016)

添加到收藏夹

Article Psychology, Multidisciplinary

Direction of Association Between Depressive Symptoms and Lifestyle Behaviors in Patients with Coronary Heart Disease: the Heart and Soul Study

Nancy L. Sin et al.

ANNALS OF BEHAVIORAL MEDICINE (2016)

添加到收藏夹

Article Geriatrics & Gerontology

Examining the association between late-life depressive symptoms, cognitive function, and brain volumes in the context of cognitive reserve

Deirdre M. O'Shea et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2015)

添加到收藏夹

Review Cell Biology

BioAge: Toward a multi-determined, mechanistic account of cognitive aging

Correne A. DeCarlo et al.

AGEING RESEARCH REVIEWS (2014)

添加到收藏夹

Review Endocrinology & Metabolism

Sex differences in cognitive impairment and Alzheimer's disease

Rena Li et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2014)

添加到收藏夹

Review Behavioral Sciences

The new science of cognitive sex differences

David I. Miller et al.

TRENDS IN COGNITIVE SCIENCES (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

CELL (2013)

添加到收藏夹

Article Mathematical & Computational Biology

Multi-stage transitional models with random effects and their application to the Einstein aging study

Changhong Song et al.

BIOMETRICAL JOURNAL (2011)

添加到收藏夹

Article Behavioral Sciences

Epigenetic gene regulation in the adult mammalian brain: Multiple roles in memory formation

Farah D. Lubin

NEUROBIOLOGY OF LEARNING AND MEMORY (2011)

添加到收藏夹

Article Geriatrics & Gerontology

Biological age and 12-year cognitive change in older adults: Findings from the Victoria Longitudinal Study

SWS MacDonald et al.

GERONTOLOGY (2004)

添加到收藏夹

Review Psychiatry

Genetic epidemiology of major depression: Review and meta-analysis

PF Sullivan et al.

AMERICAN JOURNAL OF PSYCHIATRY (2000)

添加到收藏夹

A comparison of cognitive performances based on differing rates of DNA methylation GrimAge acceleration among older men and women

相关参考文献

导出引文

分享论文