☆ 4.6 Review

The role of claudins in homeostasis

NATURE REVIEWS NEPHROLOGY (2023)

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Article Physiology

Is there a molecular basis for solvent drag in the renal proximal tubule?

Dorothee Guenzel

Summary: The concept of solvent drag involves the frictional coupling between water and solutes in the same pore for transport. It has been applied to transport processes across cell membranes and along the paracellular pathway. Water-driven solute transport has been proposed as the major mechanism for absorption in the small intestine and reabsorption in the renal proximal tubule. However, the discovery of aquaporins and the claudin protein family has led to a reassessment of the solvent drag concept for transepithelial water and solute transport.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2023)

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Review Urology & Nephrology

Renal mechanisms for hypercalciuria induced by metabolic acidosis

Gheun-Ho Kim

AMERICAN JOURNAL OF NEPHROLOGY (2023)

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Article Cell Biology

Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells

Mikio Furuse et al.

Summary: The claudin family of membrane proteins is responsible for the structure and function of tight junctions. Each claudin subtype has a unique function, and the combination of expressed subtypes determines the permeability of epithelia. Researchers attempted to reconstitute tight junctions containing only the claudin subtype(s) of interest in MDCK cells. The results showed that the reconstituted tight junctions did not contain claudin-12 and claudin-16, and overexpression of these two subtypes did not result in the reconstitution of tight junctions.

CELL STRUCTURE AND FUNCTION (2023)

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Article Urology & Nephrology

Claudin-10a Deficiency Shifts Proximal Tubular Cl- Permeability to Cation Selectivity via Claudin-2 Redistribution

Tilman Breiderhoff et al.

Summary: Recent study indicates that claudin-10a is the major paracellular anion channel in the proximal tubule, and its deficiency leads to excessive reabsorption of calcium and magnesium. Various analyses, including electrophysiological studies, suggest compensatory transcellular transport in proximal and distal tubule segments, as well as metabolic adaptation in the proximal tubule, to counterbalance the loss of paracellular anion permeability.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Meeting Abstract Biochemistry & Molecular Biology

Claudin-23 Strengthens the Colonic Epithelial Barrier by Regulating Claudin-3 and-4 proteins in the Tight Junction Plasma Membrane

Arturo Raya-Sandino et al.

FASEB JOURNAL (2022)

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Article Multidisciplinary Sciences

Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease

Hui Sun et al.

Summary: Although mature podocytes lack tight junctions, the tight junction integral membrane protein claudin-5 (CLDN5) is predominantly expressed on the plasma membranes of podocytes under normal conditions. The deletion of CLDN5 exacerbates podocyte injury and proteinuria in a diabetic nephropathy mouse model by reducing ZO1 expression, inducing nuclear translocation of ZONAB, and downregulating the expression of WNT inhibitory factor-1 (WIF1).

NATURE COMMUNICATIONS (2022)

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Article Immunology

Identification of a claudin-low subtype in clear cell renal cell carcinoma with implications for the evaluation of clinical outcomes and treatment efficacy

Cuijian Zhang et al.

Summary: In this study, we identified and characterized a claudin-low phenotype in clear cell renal cell carcinoma (ccRCC). This phenotype was associated with inferior survival, distinct tumor microenvironment (TME) and immunological features. We developed a risk signature based on the interaction between claudin-low phenotype and TME, which showed robust prognostic prediction accuracy. Our findings suggest that this signature could guide personalized management strategies for ccRCC patients.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Urology & Nephrology

Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies

Lucile Figueres et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Article Multidisciplinary Sciences

Tight junction channel regulation by interclaudin interference

Nitesh Shashikanth et al.

Summary: This study reveals a previously unrecognized mechanism of barrier regulation, in which claudin-4 reduces paracellular permeability by selectively inhibiting flux across cation channels formed by claudins 2 or 15.

NATURE COMMUNICATIONS (2022)

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Article Genetics & Heredity

A Genetic Polymorphism in the WDR72 Gene is Associated With Calcium Nephrolithiasis in the Chinese Han Population

Lujia Wang et al.

Summary: This study evaluated the association of several novel loci with calcium nephrolithiasis in the Chinese Han population. The results highlighted the significance of genetic variation at WDR72, DGKH, CLDN14, SLC34A1, and HIBADH in Chinese patients with nephrolithiasis, emphasizing the role of abnormal calcium homeostasis in calcium nephrolithiasis.

FRONTIERS IN GENETICS (2022)

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Article Multidisciplinary Sciences

Unrecognized role of claudin-10b in basolateral membrane infoldings of the thick ascending limb

Catarina Quintanova et al.

Summary: Claudin-10b is an important component of the tight junction and allows paracellular sodium transport in the thick ascending limb of Henle's loop. It colocalizes with the basolateral Na+-K+ ATPase and the Cl- channel subunit barttin, and its absence increases the accessibility of the basolateral extracellular space to certain substances. Electron microscopy reveals a widening of basolateral membrane infoldings in the absence of Claudin-10b. These findings suggest that Claudin-10b may shape neighboring membrane invaginations through trans interaction, thereby stabilizing and facilitating high-flux salt transport.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2022)

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Article Multidisciplinary Sciences

Nanoscale segregation of channel and barrier claudins enables paracellular ion flux

Hannes Gonschior et al.

Summary: Through super-resolution microscopy and fluorescence resonance energy transfer, this study reveals the nanoscale organization principles of tight junctions formed by different claudins. The segregation of channel-forming and barrier-forming claudins allows tight junctions to maintain their barrier function while enabling specific paracellular ion flux.

NATURE COMMUNICATIONS (2022)

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Article Genetics & Heredity

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury

Christian Hinze et al.

Summary: This study provides an extensive resource for understanding the cellular mechanisms and kidney cell responses associated with critical illness-associated AKI, revealing various disease-associated signatures and inter-individual heterogeneity. Personalized molecular disease assessment may contribute to the development of tailored therapies.

GENOME MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly

Sebastian Sewerin et al.

Summary: This study investigated the molecular basis and phenotypic consequences of a CLDN10 gene variant, which disrupts the assembly of tight junction (TJ) strands. The mutant proteins compromised the function of TJ and exhibited tissue-specific insertion into TJs.

GENES & DISEASES (2022)

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Article Biology

Association study of CLDN14 variations in patients with kidney stones

Ihsan Ullah et al.

Summary: This study found that CLDN14 gene mutations are associated with hearing loss and renal stone formation. Specific genotypes are significantly correlated with kidney stones, and a novel haplotype is associated with an increased risk of kidney stone formation.

OPEN LIFE SCIENCES (2022)

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Article Pharmacology & Pharmacy

Phosphoproteomic Identification of Vasopressin/cAMP/Protein Kinase A-Dependent Signaling in Kidney

Karim Salhadar et al.

Summary: This passage discusses the regulation of kidney water excretion by vasopressin through the V2R receptor and the use of modern protein mass spectrometry techniques to study protein phosphorylation changes. The data generated from phosphoproteomic studies are valuable resources for understanding vasopressin signaling and signaling downstream from other G-protein-coupled receptors.

MOLECULAR PHARMACOLOGY (2021)

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Review Transplantation

Hypoxia in chronic kidney disease: towards a paradigm shift?

Anna Faivre et al.

Summary: Chronic kidney disease (CKD) is defined as an alteration of kidney structure and/or function lasting for >3 months, affecting 10% of the general adult population. The role of hypoxia in CKD progression has been controversially discussed since the end of the last century.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

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Article Biochemistry & Molecular Biology

Activation of the calcium sensing receptor increases claudin-14 expression via a PLC-p38-Sp1 pathway

Justin J. Lee et al.

Summary: Activation of the basolateral calcium sensing receptor (CaSR) increases claudin-14 expression in the renal tubular thick ascending limb (TAL), leading to reduced paracellular calcium permeability and increased urinary Ca2+ excretion. This process involves signaling through PLC-stimulated p38 pathway and inhibition of Sp1-mediated repression.

FASEB JOURNAL (2021)

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Article Urology & Nephrology

A Comprehensive Map of mRNAs and Their Isoforms across All 14 Renal Tubule Segments of Mouse

Lihe Chen et al.

Summary: This study used a full-length, small-sample RNA-seq protocol to profile transcriptomes for all 14 renal tubule segments microdissected from mouse kidneys, identifying over 34,000 transcripts and 3709 segment-specific transcripts. Gene-expression patterns of solute carriers, transcription factors, and G protein-coupled receptors along the renal tubule were found to be important for segment-specific function.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Urology & Nephrology

A novel claudin-10 mutation with a unique mechanism in two unrelated families with HELIX syndrome

Ali S. Alzahrani et al.

Summary: A novel CLDN10 mutation was identified in two unrelated Saudi families with HELIX syndrome, disrupting the C-terminus pdz-binding motif of claudin-10. Functional studies indicated that this mutation led to mRNA degradation, protein retention in intracellular compartments, and translocation of other claudins in renal and sweat gland tissues.

KIDNEY INTERNATIONAL (2021)

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Article Medicine, Research & Experimental

Hyperglycemic levels in early stage of diabetic nephropathy affect differentially renal expression of claudins-2 and-5 by oxidative stress

Lorena Rosas-Martinez et al.

Summary: This study aims to investigate the impact of hyperglycemia on renal expression of claudins-2 and -5 in diabetic nephropathy and the role of glucose-induced oxidative stress. The results show that chronic high-glycemia levels in early stages of diabetic nephropathy decrease expression of claudins-2 and -5, increase oxidative stress, and induce MMP-activity faster than chronic middle-glycemia levels. The level of hyperglycemia plays a crucial role in the progression of diabetic nephropathy.

LIFE SCIENCES (2021)

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Article Cell Biology

Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function

Akira C. Saito et al.

Summary: The study established a tricellulin/occludin-double knockout MDCK II cell model, which showed altered TJ structure and increased paracellular permeability. Mathematical simulation suggested that reduced crosslinks in TJ strands lead to higher permeability of ions and small molecules. Overexpression of occludin enhanced complexity of TJ strand network and improved barrier function.

MOLECULAR BIOLOGY OF THE CELL (2021)

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Article Multidisciplinary Sciences

Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis

Megan R. Beggs et al.

Summary: Calcium homeostasis is maintained through coordination between intestinal absorption, renal reabsorption, and bone remodeling with tight-junction proteins called claudins playing a crucial role. Claudins-2 and -12 form independent Ca2+ permeable pores in renal and colonic epithelia, with either one sufficient to maintain Ca2+ balance. Deletion of both claudins leads to reduced intestinal Ca2+ absorption, higher urinary Ca2+ wasting, hypocalcemia, and reduced bone mineral density compared to single-null animals.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Pediatrics

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis

Monica Vall-Palomar et al.

Summary: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare kidney disease caused by mutations in the CLDN16 or CLDN19 genes, leading to low magnesium levels, high calcium in urine, and kidney calcification. There is currently no specific therapy for FHHNC, and supportive treatment is used to slow down kidney failure progression.

PEDIATRIC NEPHROLOGY (2021)

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Article Endocrinology & Metabolism

VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy

Bin Wang et al.

Summary: The study revealed that deficiency in the VDR/Atg3 axis leads to SD-TJ transition and foot process effacement in diabetic nephropathy by blocking the p62-mediated autophagy pathway.

DIABETES (2021)

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Article Cell Biology

Super-resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement

Florian Tesch et al.

Summary: Research has shown that the up-regulation of CLDN5 (a tight junction protein) in injured podocyte foot processes is associated with changes in their structure, potentially serving as a biomarker for predicting early foot process effacement.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Physiology

Expression of claudin-8 is induced by aldosterone in renal collecting duct principal cells

Ali Sassi et al.

Summary: Fine tuning of Na+ reabsorption occurs in the aldosterone-sensitive distal nephron, primarily regulated by aldosterone through ENaC and Na+ -K+/ -ATPase. Paracellular ion permeability is dependent on tight junctions, particularly claudin-8. Aldosterone coordinately regulates the expression of transcellular Na+ transporters and paracellular claudin-8. Multiple protein kinases, including GSK-3, Lyn, and Abl, mediate the aldosterone-induced upregulation of claudin-8 expression.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Article Physiology

Differential localization patterns of claudin 10, 16, and 19 in human, mouse, and rat renal tubular epithelia

Caroline Prot-Bertoye et al.

Summary: This study investigated the distribution of claudin 10, 16, and 19 in the human, mouse, and rat kidney using immunohistochemistry and immunofluorescence. The findings revealed distinct junctional pathways in both human and rodent kidneys, indicating the existence of different permeation profiles in all species investigated.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Article Physiology

Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron

Jonathan W. Nelson et al.

Summary: The study identifies a novel role for proximal tubule angiotensin receptors in regulating the abundance of Na+ transporters throughout the nephron, contributing to the integrated control of fluid balance in vivo.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Article Physiology

Renal claudin-14 expression is not required for regulating Mg2+ balance in mice

Patricia G. Ferreira et al.

Summary: This study investigated the role of Mg2+ in regulating urinary excretion of Ca2+ and Mg2+ through the Ca2+-sensing receptor-claudin 14 (CLDN14) pathway using transgenic models and in vitro assays. The results suggest that CLDN14 is unlikely to play a significant role in the compensatory response to hypermagnesemia.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Review Physiology

Thick ascending limb claudins are altered to increase calciuria and magnesiuria in metabolic acidosis

Il Hwan Oh et al.

Summary: The study revealed that metabolic acidosis-induced hypercalciuria and hypermagnesiuria are due to the down-regulation of claudin-16 and claudin-19 in the thick ascending limb via the calcium-sensing receptor and can be reversed by the calcium-sensing receptor antagonist. These findings contribute to understanding the regulatory role of paracellular tight junction proteins in the thick ascending limb.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Article Urology & Nephrology

Genetic polymorphisms in CLDN14 (rs219780) and ALP (rs1256328) genes are associated with risk of nephrolithiasis in Egyptian children

Manal F. Elshamaa et al.

Summary: The study indicated that genetic variants of CLDN14 and ALPL may increase the risk of nephrolithiasis in Egyptian children, while the SLC34A1 variant showed no significant association with the risk of nephrolithiasis.

TURKISH JOURNAL OF UROLOGY (2021)

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Article Physiology

Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2

Rita Rosenthal et al.

ACTA PHYSIOLOGICA (2020)

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Article Biochemistry & Molecular Biology

Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner

C. Hempel et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Article Urology & Nephrology

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation

Sebastien J. Dumas et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Article Biochemistry & Molecular Biology

Claudin-12 Knockout Mice Demonstrate Reduced Proximal Tubule Calcium Permeability

Allein Plain et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, Research & Experimental

Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease

Joshua N. Curry et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Urology & Nephrology

Interaction between Epithelial Sodium Channel ?-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct

Ali Sassi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Quantitative Proteomics of All 14 Renal Tubule Segments in Rat

Kavee Limbutara et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Article Physiology

Combinatorial expression of claudins in the proximal renal tubule and its functional consequences

Joshua N. Curry et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

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Renal ischemia-reperfusion injury impairs renal calcium, magnesium, and phosphate handling in mice

Manuel Meurer et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2019)

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Article Physiology

Deregulated renal magnesium transport during lipopolysaccharide-induced acute kidney injury in mice

Manuel Meurer et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2019)

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Article Multidisciplinary Sciences

The kidney anion exchanger 1 affects tight junction properties via claudin-4

Rawad Lashhab et al.

SCIENTIFIC REPORTS (2019)

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Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis

Sarah E. Graham et al.

NATURE COMMUNICATIONS (2019)

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Article Genetics & Heredity

Identification of a missense variant in CLDN2 in obstructive azoospermia

Masomeh Askari et al.

JOURNAL OF HUMAN GENETICS (2019)

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A catalog of genetic loci associated with kidney function from analyses of a million individuals

Matthias Wuttke et al.

NATURE GENETICS (2019)

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Claudin-7 Modulates Cl- and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells

Junming Fan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Claudin-19 Is Regulated by Extracellular Osmolality in Rat Kidney Inner Medullary Collecting Duct Cells

Annalisa Ziemens et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity

Tetsuhisa Otani et al.

JOURNAL OF CELL BIOLOGY (2019)

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Article Genetics & Heredity

A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe et al.

NATURE GENETICS (2019)

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Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney

Andrew Ransick et al.

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Structural Features of Tight-Junction Proteins

Udo Heinemann et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

A Novel Claudinopathy Based on Claudin-10 Mutations

Susanne Milatz

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells

Qinghong Dan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Urology & Nephrology

Hypokalemia Associated With a Claudin 10 Mutation: A Case Report

Nicole Meyers et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2019)

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Article Cell Biology

Increased osmolality enhances the tight junction-mediated barrier function in a cultured renal epithelial cell line

Leandro P. Canuto et al.

CELL BIOLOGY INTERNATIONAL (2019)

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Article Chemistry, Physical

Palmitoylation of Claudin-5 Proteins Influences Their Lipid Domain Affinity and Tight Junction Assembly at the Blood-Brain Barrier Interface

Nandhini Rajagopal et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2019)

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Article Urology & Nephrology

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis

Haojia Wu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

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Article Genetics & Heredity

Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX syndrome

Smail Hadj-Rabia et al.

GENETICS IN MEDICINE (2018)

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Article Urology & Nephrology

GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation

Christian Hinze et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Article Urology & Nephrology

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response

Haojia Wu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Article Urology & Nephrology

Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria

Tilman Breiderhoff et al.

KIDNEY INTERNATIONAL (2018)

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Article Genetics & Heredity

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Masahiro Kanai et al.

NATURE GENETICS (2018)

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Article Cell Biology

RNA sequencing of kidney distal tubule cells reveals multiple mediators of chronic aldosterone action

Soren Brandt Poulsen et al.

PHYSIOLOGICAL GENOMICS (2018)

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Article Urology & Nephrology

Claudin-14 Gene Polymorphisms and Urine Calcium Excretion

Teresa Arcidiacono et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Article Cell & Tissue Engineering

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

Haojia Wu et al.

CELL STEM CELL (2018)

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Article Physiology

Diuretic state affects ascending thin limb tight junctions

Svenja Rebecca Sonntag et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Physiology

Randall's plaque in stone formers originates in ascending thin limbs

Andrew P. Evan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Physiology

Claudin-2-mediated cation and water transport share a common pore

R. Rosenthal et al.

ACTA PHYSIOLOGICA (2017)

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Article Genetics & Heredity

Amelogenesis imperfecta in familial hypomagnesaemia and hypercalciuria with nephrocalcinosis caused by CLDN19 gene mutations

Paulo Marcio Yamaguti et al.

JOURNAL OF MEDICAL GENETICS (2017)

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Article Urology & Nephrology

Inducible Expression of Claudin-1 in Glomerular Podocytes Generates Aberrant Tight Junctions and Proteinuria through Slit Diaphragm Destabilization

Yongfeng Gong et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Review Biochemistry & Molecular Biology

The role of claudins in cancer metastasis

S. Tabaries et al.

ONCOGENE (2017)

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AVP dynamically increases paracellular Na+ permeability and transcellular NaCl transport in the medullary thick ascending limb of Henle's loop

Nina Himmerkus et al.

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Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport

Susanne Milatz et al.

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Article Genetics & Heredity

A variant in a cis-regulatory element enhances claudin-14 expression and is associated with pediatric-onset hypercalciuria and kidney stones

Megan E. Ure et al.

HUMAN MUTATION (2017)

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Article Biochemistry & Molecular Biology

Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions

Milos Mihajlovic et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Tumor Necrosis Factor- Increases Claudin-1, 4, and 7 Expression in Tubular Cells: Role in Permeability Changes

Yasaman Amoozadeh et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

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Article Urology & Nephrology

A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with CLDN10 Mutations

Ernie M. H. F. Bongers et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Acute and chronic exposure to high levels of glucose modulates tight junction-associated epithelial barrier function in a renal tubular cell line

B. M. Mongelli-Sabino et al.

LIFE SCIENCES (2017)

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Article Multidisciplinary Sciences

Aldosterone signaling regulates the overexpression of claudin-4 and-8 at the distal nephron from type 1 diabetic rats

Eduardo Molina-Jijon et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14

Tadatoshi Sato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Genetics & Heredity

Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage

Joakim Klar et al.

PLOS GENETICS (2017)

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Review Physiology

Physiological roles of claudins in kidney tubule paracellular transport

Shigeaki Muto

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

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Review Urology & Nephrology

Epidemiology and economics of nephrolithiasis

Justin B. Ziemba et al.

INVESTIGATIVE AND CLINICAL UROLOGY (2017)

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Review Urology & Nephrology

Paracellular transport and energy utilization in the renal tubule

Alan S. L. Yu

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2017)

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Review Multidisciplinary Sciences

Water channels and barriers formed by claudins

Rita Rosenthal et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

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Article Endocrinology & Metabolism

Claudin-16 Deficiency Impairs Tight Junction Function in Ameloblasts, Leading to Abnormal Enamel Formation

Claire Bardet et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Hypotonic Stress-induced Down-regulation of Claudin-1 and-2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells

Naoko Fujii et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Medicine, Research & Experimental

Paracellular epithelial sodium transport maximizes energy efficiency in the kidney

Lei Pei et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Multidisciplinary Sciences

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Cristian Pattaro et al.

NATURE COMMUNICATIONS (2016)

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Article Physiology

Ways of calcium reabsorption in the kidney

Matthias B. Moor et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

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Article Cell Biology

Tumor necrosis factor-α induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions

Yasaman Amoozadeh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)

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Article Cell Biology

The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities

Sarah Heiler et al.

CELL COMMUNICATION AND SIGNALING (2015)

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Article Gastroenterology & Hepatology

Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice

Hiroo Tanaka et al.

GUT (2015)

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Article Cell Biology

Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKC-Dependent GATA-2 in MDCK Cells

Akira Ikari et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

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Article Biochemistry & Molecular Biology

Model for the Architecture of Claudin-Based Paracellular Ion Channels through Tight Junctions

Hiroshi Suzuki et al.

JOURNAL OF MOLECULAR BIOLOGY (2015)

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Article Urology & Nephrology

Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes

Jae Wook Lee et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Article Cell Biology

Biochemical and biophysical analyses of tight junction permeability made of claudin-16 and claudin-19 dimerization

Yongfeng Gong et al.

MOLECULAR BIOLOGY OF THE CELL (2015)

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Article Multidisciplinary Sciences

Polymorphisms in CaSR and CLDN14 Genes Associated with Increased Risk of Kidney Stone Disease in Patients from the Eastern Part of India

Manalee Guha et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8

Yongfeng Gong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Urology & Nephrology

Renal Control of Calcium, Phosphate, and Magnesium Homeostasis

Judith Blaine et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Article Physiology

The claudin-16 channel gene is transcriptionally inhibited by 1,25-dihydroxyvitamin D

Orly Kladnitsky et al.

EXPERIMENTAL PHYSIOLOGY (2015)

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Article Urology & Nephrology

Epigenetic Regulation of MicroRNAs Controlling CLDN14 Expression as a Mechanism for Renal Calcium Handling

Yongfeng Gong et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Article Biochemistry & Molecular Biology

Oxidative stress induces claudin-2 nitration in experimental type 1 diabetic nephropathy

Eduardo Molina-Jijon et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

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Article Biochemistry & Molecular Biology

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice

Koichiro Susa et al.

HUMAN MOLECULAR GENETICS (2014)

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Article Biochemistry & Molecular Biology

Tight Junctional Localization of Claudin-16 Is Regulated by Syntaxin 8 in Renal Tubular Epithelial Cells

Akira Ikari et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Urology & Nephrology

Claudin-14 Underlies Ca++-Sensing Receptor-Mediated Ca++ Metabolism via NFAT-microRNA-Based Mechanisms

Yongfeng Gong et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Multidisciplinary Sciences

The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation

Yongfeng Gong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Multidisciplinary Sciences

Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions

Hiroshi Suzuki et al.

SCIENCE (2014)

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Article Pharmacology & Pharmacy

Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel

Anja Wilmes et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

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Article Cell Biology

Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines

Jiahua Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation

Akira Ikari et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

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Article Biochemistry & Molecular Biology

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

Kazuhiro Hasegawa et al.

NATURE MEDICINE (2013)

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Review Physiology

CLAUDINS AND THE MODULATION OF TIGHT JUNCTION PERMEABILITY

Dorothee Guenzel et al.

PHYSIOLOGICAL REVIEWS (2013)

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Article Physiology

Fluid reabsorption in proximal convoluted tubules of mice with gene deletions of claudin-2 and/or aquaporin1

Jurgen Schnermann et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

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Article Physiology

Activation of the Ca2+-sensing receptor increases renal claudin-14 expression and urinary Ca2+ excretion

Henrik Dimke et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

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Article Cell Biology

Claudin-4 forms a paracellular barrier, revealing the interdependence of claudin expression in the loose epithelial cell culture model opossum kidney cells

Jelena Borovac et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Claudin-17 forms tight junction channels with distinct anion selectivity

Susanne M. Krug et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

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Article Urology & Nephrology

Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis: Phenotype-Genotype Correlation and Outcome in 32 Patients with CLDN16 or CLDN19 Mutations

Astrid Godron et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

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Article Biochemistry & Molecular Biology

Claudin-14 regulates renal Ca++ transport in response to CaSR signalling via a novel microRNA pathway

Yongfeng Gong et al.

EMBO JOURNAL (2012)

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Article Medicine, Research & Experimental

PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor

Alexandre Loupy et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

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Article Multidisciplinary Sciences

Claudin-4 Deficiency Results in Urothelial Hyperplasia and Lethal Hydronephrosis

Harumi Fujita et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis

Tilman Breiderhoff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Urology & Nephrology

Regulation of magnesium balance: lessons learned from human genetic disease

Jeroen H. F. de Baaij et al.

CLINICAL KIDNEY JOURNAL (2012)

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Article Cell Biology

AT1A Angiotensin Receptors in the Renal Proximal Tubule Regulate Blood Pressure

Susan B. Gurley et al.

CELL METABOLISM (2011)

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Article Cell Biology

Decrease in Claudin-2 Expression Enhances Cell Migration in Renal Epithelial Madin-Darby Canine Kidney Cells

Akira Ikari et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes

Susanne Milatz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2010)

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Article Cell Biology

Claudin-2, a component of the tight junction, forms a paracellular water channel

Rita Rosenthal et al.

JOURNAL OF CELL SCIENCE (2010)

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Article Multidisciplinary Sciences

Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization

Jianghui Hou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Multidisciplinary Sciences

Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules

Shigeaki Muto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Multidisciplinary Sciences

Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells

Ruwan Gunaratne et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Physiology

Renal salt wasting and chronic dehydration in claudin-7-deficient mice

Rodney Tatum et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)

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Article Physiology

Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting

Constanze Will et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)

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Article Oncology

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

Aleix Prat et al.

BREAST CANCER RESEARCH (2010)

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Article Biochemistry & Molecular Biology

Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation

Salah Amasheh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

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Article Cell Biology

Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function

Dorothee Guenzel et al.

JOURNAL OF CELL SCIENCE (2009)

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Article Genetics & Heredity

Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density

Gudmar Thorleifsson et al.

NATURE GENETICS (2009)

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Article Multidisciplinary Sciences

Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium

Jianghui Hou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Physiology

Downregulation of claudin-2 expression in renal epithelial cells by metabolic acidosis

Daniel F. Balkovetz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)

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Article Biochemistry & Molecular Biology

Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16

Akira Ikari et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

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Article Oncology

Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line

Shinya Aono et al.

EXPERIMENTAL CELL RESEARCH (2008)

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Article Pathology

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

Mirna Lechpammer et al.

MODERN PATHOLOGY (2008)

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Article Cell Biology

Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes

Hiroki Fujita et al.

MOLECULAR BIOLOGY OF THE CELL (2008)

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Article Multidisciplinary Sciences

Hypertonic stress increases claudin-4 expression and tight junction integrity in association with MUPP1 in IMCD3 cells

Miguel A. Lanaspa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Cell Biology

Claudin-16 is directly phosphorylated by protein kinase A independently of a vasodilator-stimulated phosphoprotein-mediated pathway

Akira Ikari et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2008)

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Article Physiology

Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL

K. Mutig et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)

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Article Oncology

Phosphorylation of claudin-4 by PKCε regulates tight junction barrier function in ovarian cancer cells

Theresa D'Souza et al.

EXPERIMENTAL CELL RESEARCH (2007)

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Article Biochemistry & Molecular Biology

WNK4 phosphorylates ser206 of claudin-7 and promotes paracellular Cl- permeability

Rodney Tatum et al.

FEBS LETTERS (2007)

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Article Physiology

Renal localization and function of the tight junction protein, claudin-19

Susanne Angelow et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium

Jianghui Hou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Article Biochemistry & Molecular Biology

Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2

Susanne Angelow et al.

JOURNAL OF MEMBRANE BIOLOGY (2007)

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Article Genetics & Heredity

A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study

Shih-Jen Hwang et al.

BMC MEDICAL GENETICS (2007)

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Article Physiology

Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities

Christina M. Van Itallie et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)

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Article Biochemistry & Molecular Biology

Study of claudin function by RNA interference

Jianghui Hou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Urology & Nephrology

Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: Implications for albuminuria in diabetes

Minghao Ye et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

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Article Genetics & Heredity

Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement

Martin Konrad et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

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Article Endocrinology & Metabolism

Unusual clinical presentation and possible rescue of a novel Claudin-16 mutation

Dominik Mueller et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

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Article Cell Biology

Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions

A Ikari et al.

JOURNAL OF CELL SCIENCE (2006)

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Article Cell Biology

Aldosterone and tight junctions:: modulation of claudin-4 phosphorylation in renal collecting duct cells

C Le Moellic et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2005)

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Article Cell Biology

Overexpression of claudin-7 decreases the paracellular Cl- conductance and increases the paracellular Na+ conductance in LLC-PK1 cells

MD Alexandre et al.

JOURNAL OF CELL SCIENCE (2005)

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Article Cell Biology

Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice

T Miyamoto et al.

JOURNAL OF CELL BIOLOGY (2005)

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Article Cell Biology

Palmitoylation of claudins is required for efficient tight-junction localization

CM Van Itallie et al.

JOURNAL OF CELL SCIENCE (2005)

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Article Physiology

Expression of claudin-7 and-8 along the mouse nephron

WY Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)

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Article Biochemistry & Molecular Biology

Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration

T Ben-Yosef et al.

HUMAN MOLECULAR GENETICS (2003)

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Article Biochemistry & Molecular Biology

Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein

I Giménez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation

ASL Yu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Genetics & Heredity

A novel claudin 16 mutation associated with childhood hypercalciuria abolishes binding to ZO-1 and results in lysosomal mistargeting

D Muller et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2003)

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Article Cell Biology

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

S Amasheh et al.

JOURNAL OF CELL SCIENCE (2002)

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Article Physiology

Calcium-sensing receptor regulation of PTH-dependent calcium absorption by mouse cortical ascending limbs

HI Motoyama et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2002)

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Article Urology & Nephrology

The renal segmental distribution of claudins changes with development

JL Reyes et al.

KIDNEY INTERNATIONAL (2002)

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Article Cell Biology

Claudins create charge-selective channels in the paracellular pathway between epithelial cells

OR Colegio et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)

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Article Cell Biology

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice

M Furuse et al.

JOURNAL OF CELL BIOLOGY (2002)

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Article Urology & Nephrology

Paracellin-1 is critical for magnesium and calcium reabsorption in the human thick ascending limb of Henle

A Blanchard et al.

KIDNEY INTERNATIONAL (2001)

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Article Biochemistry & Molecular Biology

Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene

S Weber et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2000)

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