☆ 4.6 Review

The roles of tertiary lymphoid structures in chronic diseases

NATURE REVIEWS NEPHROLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Transplantation

Tertiary lymphoid tissues: a regional hub for kidney inflammation

Yuki Sato et al.

Summary: Tertiary lymphoid tissues (TLTs) are abnormal lymphoid tissues that develop at sites of chronic inflammation in nonlymphoid organs. They play important roles in disease severity, prognosis and therapy response. The study of TLTs in the kidney is limited, but recent findings suggest that aged kidneys can form multiple TLTs after injury, with resident fibroblasts playing a crucial role. Moreover, TLTs are suggested to have potential as markers for kidney injury/inflammation and as therapeutic targets.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

添加到收藏夹

Article Immunology

Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice

Kevin M. Nickerson et al.

Summary: Age-associated B cells (ABCs) are a type of memory B cell expressing the transcription factor T-bet, formed under inflammatory conditions. In systemic lupus erythematosus (SLE), ABC frequency is correlated with disease and they are considered the source of autoantibody-secreting cells. The heterogeneity of ABCs and their relationship to other B cell subsets such as plasmablasts is unclear. The study shows that ABCs are dynamic and can be plasmablast precursors or undergo cycles of reactivation. Deletion of CD11c-expressing B cells reveals a direct role for ABC-like B cells in lupus pathogenesis.

JOURNAL OF EXPERIMENTAL MEDICINE (2023)

添加到收藏夹

Article Urology & Nephrology

Tubulointerstitial B-cell infiltration and tertiary lymphoid tissue in adult-onset immunoglobulin A vasculitis with nephritis

Ryo Togashi et al.

Summary: This study examined tubulointerstitial B-cell infiltration in patients with adult-onset IgAV-N and found that it was associated with renal dysfunction and tubulointerstitial injuries, but not with glomerular injury parameters. B-cell infiltration and TLT might play a significant role in irreversible renal dysfunction in patients with early-phase adult-onset IgAV-N.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2023)

添加到收藏夹

Review Immunology

Tissue-Resident Immune Cells in Humans

Joshua Gray et al.

Summary: Tissue-resident immune cells play integral roles in immune responses in humans, but studying them is challenging. Recent advances have provided new insights into the origin, development, and functional roles of tissue-resident immune cells.

ANNUAL REVIEW OF IMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

Assia Asrir et al.

Summary: Tumor-associated high endothelial venules (TA-HEVs) are crucial for recruiting lymphocytes into tumors, and their presence is associated with better response and survival in anti-PD-1/anti-CTLA-4 treatment. TA-HECs co-express specific proteins and selectins, which attract lymphocytes to infiltrate tumors. Understanding the mechanism of lymphocyte trafficking in cancer immunity and immunotherapy is important for improving treatment outcomes.

CANCER CELL (2022)

添加到收藏夹

Article Urology & Nephrology

Close Association between Altered Urine-Urothelium Barrier and Tertiary Lymphoid Structure Formation in the Renal Pelvis during Nephritis

Osamu Ichii et al.

Summary: Regardless of urinary tract infection, urinary tract-associated lymphoid structures (UTALSs) form in the renal pelvis of patients with chronic nephritis. Urine plays a unique role in UTALS formation by affecting urothelial barrier integrity and stimulating immune responses. These findings reveal a novel mechanism underlying the pathogenesis of chronic nephritis involving UTALS formation.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Editorial Material Urology & Nephrology

A Novel Pathological Mechanism of Tertiary Lymphoid Structure Formation in the Renal Pelvis

Shinya Yamamoto et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Advanced Tertiary Lymphoid Tissues in Protocol Biopsies are Associated with Progressive Graft Dysfunction in Kidney Transplant Recipients

Yu Ho Lee et al.

Summary: Tertiary lymphoid tissues (TLTs) are commonly found in transplanted kidneys and advanced TLTs are associated with graft dysfunction.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Review Multidisciplinary Sciences

Tertiary lymphoid structures in cancer

Ton N. Schumacher et al.

Summary: This article discusses the current knowledge on TLSs in cancer, focusing on the drivers of TLS formation, the function and contribution of TLSs to the antitumor immune response, and the potential of TLSs as therapeutic targets in human cancers.

SCIENCE (2022)

添加到收藏夹

Article Immunology

Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer

Fabio Pagliarulo et al.

Summary: Lymphoid neogenesis in muscle invasive bladder cancer (MIBC) leads to the formation of tertiary lymphoid structures (TLS) in the tumor microenvironment (TME), which have positive prognostic and predictive associations. This study found that high TLS density, when combined with tumor mutational burden, serves as a novel independent prognostic biomarker in MIBC. Tumors with high TLS density showed increased gene signatures and infiltration of activated lymphocytes, particularly B-cell and CD8(+) T-cell co-infiltration. The study also identified TLS maturation subtypes, although TLS composition appeared to be influenced by the TME rather than the maturation status.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

Intratumor expanded T cell clones can be non-sentinel lymph node derived in breast cancer revealed by single-cell immune profiling

Shiping Jiao et al.

Summary: This study revealed expanded intratumor non-sentinel LN derived T cell clones, indicating the need to explore the role of TLS in antitumor immunity.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

添加到收藏夹

Article Medicine, General & Internal

Characteristics and Prognostic Value of Tertiary Lymphoid Organs in Membranous Nephropathy: A Retrospective Study

Zu-feng Wang et al.

Summary: This study demonstrates the prevalence of TLOs in patients with MN and shows that patients with MN with TLOs have worse clinical manifestation and outcomes compared to patients without TLOs. Furthermore, the presence of TLOs is associated with specific clinical features and positive antibody status, highlighting their importance in MN.

FRONTIERS IN MEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

Roei D. Mazor et al.

Summary: This study found that somatic hypermutations (SHMs) promote antibody antitumor reactivity against surface autoantigens in high-grade serous ovarian carcinoma (HGSOC). The tumor-reactive antibodies target MMP14, which is abundantly expressed on the tumor cell surface. These findings highlight the origin and potential applicability of autoantibodies directed at surface antigens for tumor targeting in cancer patients.

CELL (2022)

添加到收藏夹

Article Immunology

Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing cells in renal cell cancer

Maxime Meylan et al.

Summary: The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in renal cell carcinoma (RCC). B cells are enriched in TLS and demonstrate diverse maturation stages, with the presence of fully mature clonotypes. Additionally, IgG-and IgA-producing plasma cells (PCs) disseminate into the tumor beds along fibroblastic tracks in TLS+ tumors, indicating potential anti-tumor effector activity. Furthermore, the presence of IgG-stained tumor cells correlates with therapeutic responses and progression-free survival in RCC patients treated with immune checkpoint inhibitors.

IMMUNITY (2022)

添加到收藏夹

Article Urology & Nephrology

Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors

Keiichi Kaneko et al.

Summary: This study reveals the behavior of Epo-producing cells during kidney fibrosis. These cells can transdifferentiate into myofibroblasts and lose their Epo-producing ability, while exhibiting high proliferative capacity during fibrosis. However, when the ureteral obstruction is relieved, these cells can regain their Epo-producing ability.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort

A. Italiano et al.

Summary: Immune checkpoint inhibitors have limited clinical activity in patients with advanced soft-tissue sarcomas. The presence of TLSs may serve as a potential predictive biomarker for the effectiveness of pembrolizumab treatment in these patients.

NATURE MEDICINE (2022)

添加到收藏夹

Review Oncology

B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome

Wolf H. Fridman et al.

Summary: B cells play a critical role in the tumor microenvironment, particularly within tertiary lymphoid structures (TLS). The presence of mature TLS, high density of B cells and plasma cells, and antibodies targeting tumor-associated antigens are associated with favorable clinical outcomes and response to immunotherapy. However, polyclonal B cell activation can lead to pro-inflammatory responses. Novel therapeutic approaches are being explored to enhance the development of TLS and anti-tumor B cells for cancer therapy.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

添加到收藏夹

Review Immunology

T cell help in the autoreactive germinal center

Elliot H. Akama-Garren et al.

Summary: The germinal center serves as a crucial site for B cell selection and affinity maturation, with follicular T cells playing a key role in this process. Recent studies have elucidated the emerging roles of follicular T cells in autoimmune reactions and their potential therapeutic targets.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Reversible CD8 T cell-neuron cross-talk causes aging- dependent neuronal regenerative decline

Luming Zhou et al.

Summary: Aging is associated with increased prevalence of axonal injuries, and the underlying mechanisms remain unclear. This study found that T cell signaling is enriched in mice before and after sciatic nerve injury (SNI), and this signaling promotes immune cell recruitment and axonal injury through the activation of specific proteins. Inhibition of T cell recruitment facilitates axonal regeneration.

SCIENCE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures

Susanne Fleig et al.

Summary: Loss of endothelial Notch signaling in adult mice leads to spontaneous formation of bona fide TLS in non-lymphoid organs like the kidney, liver, and lung. These TLS form around parenchymal arteries and involve loss of arterial specification and acquisition of a high endothelial cell phenotype.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Oncology

Unique characteristics of tertiary lymphoid structures in kidney clear cell carcinoma: prognostic outcome and comparison with bladder cancer

Tsukasa Masuda et al.

Summary: This study compared the characteristics of tertiary lymphoid structures (TLS) between clear cell renal cell carcinoma (ccRCC) and bladder cancer, and found significant differences in TLS status, prognostic impact, maturity and spatial distribution, as well as the immune microenvironment surrounding TLSs between the two cancers.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

添加到收藏夹

Article Medicine, Research & Experimental

CXCL13-producing CD4+T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer

Masayo Ukita et al.

Summary: The formation of tertiary lymphoid structures (TLS) is associated with CXCL13-producing CD4+ T cells, and TLS facilitates the coordinated antitumor response of cellular and humoral immunity in ovarian cancer.

JCI INSIGHT (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination

Aloysious Ssemaganda et al.

Summary: This study investigates T cells in the nasal mucosa and blood after vaccination with the Pfizer-BioNTech COVID-19 vaccine. The results show an increase in tissue-resident memory CD8(+) T cells expressing CD69(+)CD103(+) in the nasal mucosa after the first and second doses, while CD69(+)CD103(+)CD8(+) T cells in the blood decrease post-vaccination. There is also an increase in nasal CD8(+)CD69(+)CD103(-) T cells, particularly following the second dose. Additionally, CD4(+) cells co-expressing CCR6 and CD161 are increased in abundance following both doses. Stimulation of nasal CD8(+) T cells with SARS-CoV-2 spike peptides elevates expression of CD107a and cytokines.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling

Adrian Gomez-Nguyen et al.

Summary: The study found that psychological stress can induce the formation of colonic TLOs through intrinsic alterations in IL-23 signaling, rather than through extrinsic influence from the microbiome. Furthermore, chronic stress is protective against secondary insult from colitis, suggesting that TLOs may improve mucosal barrier function.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Cell Biology

cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells

Yuji Fukushima et al.

Summary: This study reveals that the interaction between CD153 and CD30 plays a crucial role in the reciprocal activation of SA-T and Spt-GC B cells during aging, leading to immunosenescent phenotypes and autoimmunity.

CELL REPORTS (2022)

添加到收藏夹

Article Medicine, General & Internal

Decreased Tertiary Lymphoid Structures in Lung Adenocarcinomas with ALK Rearrangements

Yi Zou et al.

Summary: This study found that ALK+ LUAD has lower TLS formation and immune cell density, which is closely related to tumor progression and may contribute to the poor efficiency of ICIs.

JOURNAL OF CLINICAL MEDICINE (2022)

添加到收藏夹

Article Oncology

Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

Yichao Hua et al.

Summary: The lack of T cell infiltrates hinders effective immunotherapy in cancer, while the formation of tumor-associated tertiary-lymphoid-like structures (TA-TLLSs) is associated with a good prognosis. This study reveals that antiangiogenic immune-modulating therapies can induce the transformation of postcapillary venules into inflamed high-endothelial venules (HEVs) through lymphotoxin/lymphotoxin beta receptor (LT/LTbR) signaling. Tumor HEVs enhance intratumoral lymphocyte influx and promote the differentiation of CD8 T cell progenitors into effector cells, contributing to tumor immunotherapy.

CANCER CELL (2022)

添加到收藏夹

Article Medicine, Research & Experimental

CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury

Yuki Sato et al.

Summary: The CD153/CD30 signaling pathway plays an important role in the formation of Tertiary lymphoid tissues (TLTs), which can slow down the progression of kidney disease.

JOURNAL OF CLINICAL INVESTIGATION (2022)

添加到收藏夹

Review Immunology

Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis

Simin Jamaly et al.

Summary: Kidney involvement in patients with systemic lupus erythematosus (SLE) leads to significant morbidity and mortality, with lupus nephritis (LN) pathogenesis involving diverse mechanisms driven by autoimmune response elements. This alters the biology of kidney resident cells, with processes in the glomeruli and interstitium potentially proceeding independently but with inevitable crosstalk. Various cells and molecules play a role in the injury and damage of the kidney, and targeting these components therapeutically may prevent or reverse kidney failure. Additionally, tertiary lymphoid structures in the kidneys of patients with lupus nephritis have been associated with poorer renal outcomes, formed by a complex interaction of immune cells and kidney resident cells.

AUTOIMMUNITY REVIEWS (2021)

添加到收藏夹

Article Dermatology

Tertiary lymphoid structures with overlapping histopathologic features of cutaneous marginal zone lymphoma during neoadjuvant cemiplimab therapy are associated with antitumor response

Keith J. Sweeney et al.

Summary: The development of immune checkpoint inhibitor therapy has shifted the paradigm in cancer treatment, with neoadjuvant ICI therapy followed by surgery becoming the standard of care for several advanced-stage cancers. The pathology associated with ICI therapy includes tissue reactions, activation of TLSs, and off-target immune-related adverse events, with clonal expansion of B-cells in TLSs during neoadjuvant therapy being a critical factor in recognizing the response to ICI therapy.

JOURNAL OF CUTANEOUS PATHOLOGY (2021)

添加到收藏夹

Review Immunology

Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role

Catarina Gago da Graca et al.

Summary: This review focuses on the role of lymph node stromal cells and TLSs in coordinating adaptive immune responses and their potential impact on diseases, particularly autoimmunity and cancer. The discussion includes recent findings on the function and formation of these structures and their possible role in promoting tolerance.

JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor

Rafael S. Czepielewski et al.

Summary: The formation of tertiary lymphoid organs (TLOs) in the mesentery is a feature of Crohn's disease, blocking cellular and molecular outflow from the gut and causing lymph leakage and backflow. TNF neutralization at early stages can restore lymph transport, but developed chronic TLOs resist regression and restoration of flow after TNF neutralization. TNF stimulation of lymphatic endothelial cells disrupts immune cell transport and valve-associated gene induction, contributing to Crohn's disease pathology.

IMMUNITY (2021)

添加到收藏夹

Article Urology & Nephrology

Tertiary lymphoid tissue in early-stage IgG4-related tubulointerstitial nephritis incidentally detected with a tumor lesion of the ureteropelvic junction: a case report

Tatsuhito Miyanaga et al.

Summary: The case report describes a 72-year-old Japanese man with IgG4-related kidney disease and the presence of tertiary lymphoid tissue (TLT) containing germinal centers. The study suggests that TLT formation is related to the development of IgG4-TIN and may help elucidate the pathophysiology of IgG4-TIN.

BMC NEPHROLOGY (2021)

添加到收藏夹

Article Oncology

CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer

Moran Yang et al.

Summary: This study reveals the critical role of CXCL13 in shaping the antitumor microenvironment by facilitating the maintenance of CXCR5(+)CD8(+) T cells in TLSs, and supports a clinical investigation for a combination of CXCL13 and PD-1 blockade therapy in HGSC.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Article Immunology

T resident helper cells promote humoral responses in the lung

Nivedya Swarnalekha et al.

Summary: Following influenza infection, long-lived T-RH cells are established in the lung, dependent on B cells in iBALT, for rapid response to subsequent infections. Deletion of Bcl6 in CD4(+) T cells results in redistribution of T cells and impaired local antibody production.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

Kevin Litchfield et al.

Summary: Checkpoint inhibitors (CPIs) enhance adaptive immunity, with clonal tumor mutation burden (TMB) identified as the strongest predictor of CPI response. Dinucleotide variants may serve as a source of immunogenic epitopes, while copy-number alterations and HLA evolutionary divergence lack pan-cancer significance.

CELL (2021)

添加到收藏夹

Article Immunology

Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

Peter A. Szabo et al.

Summary: This study investigated the immune responses in the respiratory tract and blood of severe COVID-19 patients, revealing that T cells in the airways showed protective profiles while myeloid cells exhibited hyperinflammatory signatures. These findings provide important insights for understanding and treating COVID-19 lung pathology.

IMMUNITY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Simultaneous targeting of primary tumor, draining lymph node, and distant metastases through high endothelial venule-targeted delivery

Liwei Jiang et al.

Summary: The newly developed MHA112-Taxol drug delivery platform can simultaneously target tumors, TDLNs, and metastatic lesions, effectively reducing the size of primary tumors and the number of metastatic lesions.

NANO TODAY (2021)

添加到收藏夹

Review Peripheral Vascular Disease

High endothelial venules (HEVs) in immunity, inflammation and cancer

Lucas Blanchard et al.

Summary: High endothelial venules (HEVs) are essential for lymphocyte circulation and immune surveillance in lymph nodes and secondary lymphoid organs. These specialized blood vessels expand during inflammation and play important roles in chronic inflammatory diseases. MECA-79(+) tumor-associated HEVs also play crucial roles in promoting lymphocyte entry into tumors in cancer immunotherapy.

ANGIOGENESIS (2021)

添加到收藏夹

Article Oncology

Tertiary lymphoid structures show infiltration of effective tumor-resident T cells in gastric cancer

Takuya Mori et al.

Summary: Multiple studies have shown that CD103(+) T cells in the tumor microenvironment of gastric cancer are associated with a better prognosis, especially when combined with TLSs. Patients with both CD103(high) cells and rich TLSs tend to have a better response to PD-1 blockade therapy, indicating enhanced antitumor immunity in GC.

CANCER SCIENCE (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes

Eva Korpos et al.

Summary: TLOs were found in the pancreas of individuals with type 1 diabetes, showing similarities with TLOs in NOD mouse pancreases. These TLOs may play a crucial role in autoimmune processes, especially in relation to insulin-containing islets, with their frequency decreasing as beta cell loss severity increases.

DIABETOLOGIA (2021)

添加到收藏夹

Article Oncology

Tertiary lymphoid structures marker CXCL13 is associated with better survival for patients with advanced-stage bladder cancer treated with immunotherapy

Clarice S. Groeneveld et al.

Summary: The study revealed that CXCL13 transcript expression is a prognostic biomarker for ICI-treated MIBC patients and serves as a marker of TLS in MIBC, indicating its predictive value for response to ICI therapy.

EUROPEAN JOURNAL OF CANCER (2021)

添加到收藏夹

Review Immunology

Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney

Hiroyuki Arai et al.

Summary: Fibroblasts play important roles in maintaining tissue structure and homeostasis under physiological conditions, but their phenotypic alterations can lead to various pathological conditions. Recent research has shown that fibroblasts consist of heterogeneous subpopulations with both beneficial and detrimental effects in a context-dependent manner, particularly in the development of chronic kidney disease in the kidney.

IMMUNOLOGICAL REVIEWS (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

Maya M. L. Poon et al.

Summary: Research has shown that SARS-CoV-2-specific immune memory persists in organs for up to 6 months post-infection, with lungs and lymph nodes being the most prevalent sites, indicating coordinated local tissue immunity for protection against future infections.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development

Jessica N. Filderman et al.

Summary: Tertiary lymphoid structures (TLS) are unique lymphoid tissues that conditionally form in peripheral tissues in a milieu of sustained inflammation, serving as regional sites for induction and expansion of the host B and T cell repertoires. Therapeutic strategies targeting DC, VEC, and local cytokine/chemokine profiles actively promote TLS formation and the development of an inflammatory tumor microenvironment.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Oncology

Immune checkpoint inhibitors in treatment of soft-tissue sarcoma: A systematic review and meta-analysis

Michael Saerens et al.

Summary: The study evaluates the activity of ICPIs in the treatment of soft-tissue sarcomas (STS), revealing significant differences in their performance based on histologic subtype, disease setting, and combination treatment strategy. ICPIs showed high clinical activity in classic Kaposi sarcoma, alveolar soft part sarcoma, and undifferentiated pleomorphic sarcoma subtypes.

EUROPEAN JOURNAL OF CANCER (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

Luuk van Hooren et al.

Summary: This study demonstrates that the use of immunostimulatory CD40 antibodies in glioma models promotes the formation of tertiary lymphoid structures but does not improve survival and impairs the response to immune checkpoint blockade.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

Ayana T. Ruffin et al.

Summary: The study suggests that enhancing TIL-B responses in HNSCC, particularly in HPV+ cases, could complement current T cell immunotherapies. The presence of tumor infiltrating B cells with GCs in TLS is associated with better survival outcomes in head and neck squamous cell carcinoma patients.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Cell Biology

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

Anthony B. Rodriguez et al.

Summary: The study reveals that the development of tumor-associated tertiary lymphoid structures (TA-TLS) is orchestrated by cancer-associated fibroblasts (CAF) with characteristics of lymphoid tissue organizer cells, mediated by CD8 T cells and CXCL13-mediated recruitment of B cells. The presence and size of TA-TLS are correlated with reduced tumor size and overall response to checkpoint immunotherapy, providing a potential platform for cancer immunotherapy strategy.

CELL REPORTS (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice

Francesca R. Delvecchio et al.

Summary: The study indicates that inducing TLS in pancreatic cancer may enhance the antitumor activity of chemotherapy, and combination chemotherapy and immunotherapy can induce TLS formation, ultimately leading to tumor reduction.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

添加到收藏夹

Article Oncology

Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression

Lucile Vanhersecke et al.

Summary: The presence of mature tertiary lymphoid structures is associated with improved response to immunotherapy in cancer patients, predicting objective response rates, progression-free survival, and overall survival. These findings support the potential use of TLS detection to select patients who are more likely to benefit from immune checkpoint blockade.

NATURE CANCER (2021)

添加到收藏夹

Article Oncology

Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer

Andrew J. Gunderson et al.

Summary: PDAC tumors show T cell inflamed phenotypes, with some tumors having early-stage TLS which correlates with higher survival rates.

ONCOIMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Regulation of immune responses by the airway epithelial cell landscape

Richard J. Hewitt et al.

Summary: The community of cells lining our airways collaborates in maintaining immune homeostasis in the lung and protecting against pathogens and pollutants in the air. Single-cell RNA-sequencing reveals cellular heterogeneity in the airway wall and identifies novel cell populations with unique molecular signatures and functions in health and disease. This review discusses the evolving understanding of the airway epithelial landscape with a focus on interactions with the local neuronal and immune systems.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Tertiary lymphoid organs are associated with the progression of kidney damage and regulated by interleukin-17A

Ran Luo et al.

Summary: Renal TLOs are associated with the severity of IgA nephropathy and serve as independent risk factors for disease progression. Inhibiting the formation of renal TLOs can reduce intrarenal inflammation and fibrosis, with early intervention being more effective. IL-17A plays a role in the formation of renal TLOs, and genetic depletion or treatment with anti-IL-17A antibody can reduce TLOs formation and alleviate renal inflammation and fibrosis.

THERANOSTICS (2021)

添加到收藏夹

Article Cell Biology

Existence of intratumoral tertiary lymphoid structures is associated with immune cells infiltration and predicts better prognosis in early-stage hepatocellular carcinoma

Hui Li et al.

AGING-US (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice

Simone Ragusa et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

添加到收藏夹

Article Multidisciplinary Sciences

B cells are associated with survival and immunotherapy response in sarcoma

Florent Petitprez et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

Rita Cabrita et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

NATURE (2020)

添加到收藏夹

Review Immunology

The Implications of B-lineage Cells in Kidney Allografts

Edward J. Filippone et al.

TRANSPLANTATION (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

Yukun Huang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Oncology

The Immunosuppressive Niche of Soft-Tissue Sarcomas is Sustained by Tumor-Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures

Lingling Chen et al.

CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Medicine, General & Internal

Lupus nephritis

Hans-Joachim Anders et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

添加到收藏夹

Review Urology & Nephrology

Pathophysiology of AKI to CKD progression

Yuki Sato et al.

SEMINARS IN NEPHROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

Shota Yoshida et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Urology & Nephrology

Developmental stages of tertiary lymphoid tissue reflect local injury and inflammation in mouse and human kidneys

Yuki Sato et al.

KIDNEY INTERNATIONAL (2020)

添加到收藏夹

Article Immunology

Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation

Marianne M. Ligon et al.

MUCOSAL IMMUNOLOGY (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Biological functions of lymphatic vessels

Tatiana V. Petrova et al.

SCIENCE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ectopic Lymphoid Organs and Immune-Mediated Diseases: Molecular Basis for Pharmacological Approaches

Luca Antonioli et al.

TRENDS IN MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

Nick van Dijk et al.

NATURE MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma

Jianjun Gao et al.

NATURE MEDICINE (2020)

添加到收藏夹

Article Immunology

Vasculature-Associated Lymphoid Tissue: A Unique Tertiary Lymphoid Tissue Correlates With Renal Lesions in Lupus Nephritis Mouse Model

Md. Abdul Masum et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Thomas M. Conlon et al.

NATURE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma

Julien Calderaro et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Immunology

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

Madelene W. Dahlgren et al.

IMMUNITY (2019)

添加到收藏夹

Article Immunology

Type I interferon induces CXCL13 to support ectopic germinal center formation

Alice E. Denton et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation

Pietro E. Cippa et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Review Immunology

Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases

Nancy D. Marin et al.

JOURNAL OF IMMUNOLOGY (2019)

添加到收藏夹

Letter Critical Care Medicine

B Cell-Adaptive Immune Profile in Emphysema-Predominant Chronic Obstructive Pulmonary Disease

John-Lawrence Sullivan et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

Saba Nayar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

Maria Carolina Amezcua Vesely et al.

CELL (2019)

添加到收藏夹

Review Urology & Nephrology

Immunology of the ageing kidney

Yuki Sato et al.

NATURE REVIEWS NEPHROLOGY (2019)

添加到收藏夹

Review Immunology

Adventitial Cuffs: Regional Hubs for Tissue Immunity

Madelene W. Dahlgren et al.

TRENDS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Yehezqel Elyahu et al.

SCIENCE ADVANCES (2019)

添加到收藏夹

Article Immunology

CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

Tomomi Ichikawa et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹

Review Multidisciplinary Sciences

Functional heterogeneity of resident fibroblasts in the kidney

Yuki Sato et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2019)

添加到收藏夹

Article Cell Biology

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

Christina D. Camell et al.

CELL METABOLISM (2019)

添加到收藏夹

Review Immunology

Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis

Shanshan Luo et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Tertiary lymphoid structures in the choroid plexus in neuropsychiatric lupus

Ariel D. Stock et al.

JCI INSIGHT (2019)

添加到收藏夹

Review Oncology

Tertiary lymphoid structures in the era of cancer immunotherapy

Catherine Sautes-Fridman et al.

NATURE REVIEWS CANCER (2019)

添加到收藏夹

Article Oncology

Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

Florian Posch et al.

ONCOIMMUNOLOGY (2018)

添加到收藏夹

Article Oncology

Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T-cell Interplay

Marilena Gallotta et al.

CANCER RESEARCH (2018)

添加到收藏夹

Article Cell Biology

Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

Silke R. Brix et al.

HISTOPATHOLOGY (2018)

添加到收藏夹

Article Immunology

Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis

Yuki Morimoto et al.

IMMUNITY (2018)

添加到收藏夹

Article Immunology

Regulation of age-associated B cells by IRF5 in systemic autoimmunity

Michela Manni et al.

NATURE IMMUNOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Daniela S. Thommen et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Immunology

Induction of Tertiary Lymphoid Structures With Antitumor Function by a Lymph Node-Derived Stromal Cell Line

Genyuan Zhu et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Oncology

Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas A Phase 2 Clinical Trial

Maud Toulmonde et al.

JAMA ONCOLOGY (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Inflammaging: a new immune-metabolic viewpoint for age-related diseases

Claudio Franceschi et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

添加到收藏夹

Article Oncology

Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma

Karina Silina et al.

CANCER RESEARCH (2018)

添加到收藏夹

Review Physiology

Immune cells and inflammation in AKI to CKD progression

Yuki Sato et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

添加到收藏夹

Review Immunology

The impact of senescence-associated T cells on immunosenescence and age-related disorders

Yuji Fukushima et al.

INFLAMMATION AND REGENERATION (2018)

添加到收藏夹

Article Respiratory System

Bacteria-driven peribronchial lymphoid neogenesis in bronchiectasis and cystic fibrosis

Justine Frija-Masson et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

添加到收藏夹

Article Medicine, Research & Experimental

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

Kira Rubtsova et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Deepak A. Rao et al.

NATURE (2017)

添加到收藏夹

Review Rheumatology

Ectopic lymphoid neogenesis in rheumatic autoimmune diseases

Michele Bombardieri et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

添加到收藏夹

Article Cell Biology

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation

Elizabeth Allen et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

添加到收藏夹

Article Oncology

Expression of Myxovirus Resistance A (MxA) Is Associated with Tumor-Infiltrating Lymphocytes in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancers

So Jeong Lee et al.

CANCER RESEARCH AND TREATMENT (2017)

添加到收藏夹

Article Cell Biology

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

Medya Mara Shikhagaie et al.

CELL REPORTS (2017)

添加到收藏夹

Article Immunology

De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors

Anna Johansson-Percival et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹

Article Urology & Nephrology

Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps

Hamid Rabb et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

添加到收藏夹

Article Oncology

Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma

Giovanni Francesco Castino et al.

ONCOIMMUNOLOGY (2016)

添加到收藏夹

Article Immunology

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation

Etsushi Kuroda et al.

IMMUNITY (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Obesity accelerates T cell senescence in murine visceral adipose tissue

Kohsuke Shirakawa et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

添加到收藏夹

Article Oncology

Tumor-Infiltrating Lymphocytes, Crohn's-Like Lymphoid Reaction, and Survival From Colorectal Cancer

Laura S. Rozek et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Ionic immune suppression within the tumour microenvironment limits T cell effector function

Robert Eil et al.

NATURE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Age-dependent modulation of vascular niches for haematopoietic stem cells

Anjali P. Kusumbe et al.

NATURE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation

Kenta Shinoda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

添加到收藏夹

Article Cell Biology

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

Marios Giannakis et al.

CELL REPORTS (2016)

添加到收藏夹

Article Oncology

Tumor-Infiltrating Lymphocytes, Crohn's-Like Lymphoid Reaction, and Survival From Colorectal Cancer

Laura S. Rozek et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

添加到收藏夹

Article Oncology

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma

Isabel Poschke et al.

ONCOIMMUNOLOGY (2016)

添加到收藏夹

Review Immunology

Tissue-resident memory T cells: local specialists in immune defence

Scott N. Mueller et al.

NATURE REVIEWS IMMUNOLOGY (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Yuki Sato et al.

JCI INSIGHT (2016)

添加到收藏夹

Article Pathology

Prognostic Significance of Tumor-Infiltrating Lymphocytes and the Tertiary Lymphoid Structures in HER2-Positive Breast Cancer Treated With Adjuvant Trastuzumab

Hee Jin Lee et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2015)

添加到收藏夹

Review Immunology

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

Christopher D. Buckley et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

添加到收藏夹

Article Oncology

Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients

Stine L. Figenschau et al.

BMC CANCER (2015)

添加到收藏夹

Article Immunology

Integration of Th17-and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

Natalia B. Pikor et al.

IMMUNITY (2015)

添加到收藏夹

Article Medicine, Research & Experimental

High salt reduces the activation of IL-4-and IL-13-stimulated macrophages

Katrina J. Binger et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

添加到收藏夹

Article Immunology

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

Yu Adachi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

添加到收藏夹

Article Immunology

A CD153+CD4+ T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production

Suhail Tahir et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Immunology

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

Shlomi Finkin et al.

NATURE IMMUNOLOGY (2015)

添加到收藏夹

Review Immunology

The balance between protective and pathogenic immune responses in the TB-infected lung

Ian M. Orme et al.

NATURE IMMUNOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

Francesca Barone et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

Deepak Kaushal et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Oncology

A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4(+) T cell receptor repertoire clonality

Wei Zhu et al.

ONCOIMMUNOLOGY (2015)

添加到收藏夹

Article Urology & Nephrology

Renal Interstitial Infiltration and Tertiary Lymphoid Organ Neogenesis in IgA Nephropathy

Guangchang Pei et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

添加到收藏夹

Review Medicine, Research & Experimental

Lymphatic vessels and tertiary lymphoid organs

Nancy H. Ruddle

JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹

Article Virology

Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

Rudragouda Channappanavar et al.

JOURNAL OF VIROLOGY (2014)

添加到收藏夹

Article Immunology

TNFα-dependent development of lymphoid tissue in the absence of RORγt+ lymphoid tissue inducer cells

G. C. Furtado et al.

MUCOSAL IMMUNOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of Novel Genes Associated with Renal Tertiary Lymphoid Organ Formation in Aging Mice

Yuan Huang et al.

PLOS ONE (2014)

添加到收藏夹

Article Cell Biology

Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

Vladimir M. Liarski et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

添加到收藏夹

Article Medicine, General & Internal

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma

Anna M. Wirsing et al.

BMC CLINICAL PATHOLOGY (2014)

添加到收藏夹

Review Immunology

Ectopic lymphoid-like structures in infection, cancer and autoimmunity

Costantino Pitzalis et al.

NATURE REVIEWS IMMUNOLOGY (2014)

添加到收藏夹

Article Oncology

Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Romain Remark et al.

CLINICAL CANCER RESEARCH (2013)

添加到收藏夹

Article Immunology

IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia

Corey N. Miller et al.

INTERNATIONAL IMMUNOLOGY (2013)

添加到收藏夹

Article Immunology

Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis

R. Gopal et al.

MUCOSAL IMMUNOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Markus Kleinewietfeld et al.

NATURE (2013)

添加到收藏夹

Review Physiology

Renal anemia: from incurable to curable

Yuki Sato et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

Nike Julia Krautler et al.

CELL (2012)

添加到收藏夹

Article Hematology

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

Yi Hao et al.

BLOOD (2011)

添加到收藏夹

Article Hematology

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

Anatoly V. Rubtsov et al.

BLOOD (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

Nariaki Asada et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Article Immunology

In Situ B Cell-Mediated Immune Responses and Tubulointerstitial Inflammation in Human Lupus Nephritis

Anthony Chang et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹

Article Immunology

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

Javier Rangel-Moreno et al.

NATURE IMMUNOLOGY (2011)

添加到收藏夹

Article Immunology

Chronic Rejection Triggers the Development of an Aggressive Intragraft Immune Response through Recapitulation of Lymphoid Organogenesis

Olivier Thaunat et al.

JOURNAL OF IMMUNOLOGY (2010)

添加到收藏夹

Article Urology & Nephrology

Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system

Feng Yu et al.

KIDNEY INTERNATIONAL (2010)

添加到收藏夹

Article Immunology

Clinical Impacts of CD38+ B Cells on Acute Cellular Rejection With CD20+ B Cells in Renal Allograft

Hyeon Seok Hwang et al.

TRANSPLANTATION (2010)

添加到收藏夹

Article Rheumatology

Extranodal Lymphoid Microstructures in Inflamed Muscle and Disease Severity of New-Onset Juvenile Dermatomyositis

Consuelo M. Lopez de Padilla et al.

ARTHRITIS AND RHEUMATISM (2009)

添加到收藏夹

Article Immunology

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice

Corine H. GeurtsvanKessel et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

添加到收藏夹

Article Immunology

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice

Rolf Graebner et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

添加到收藏夹

Article Immunology

Ectopic Germinal Centers Are Rare in Sjogren's Syndrome Salivary Glands and Do Not Exclude Autoreactive B Cells

Laetitia Le Pottier et al.

JOURNAL OF IMMUNOLOGY (2009)

添加到收藏夹

Article Urology & Nephrology

Acute Kidney Injury Increases Risk of ESRD among Elderly

Areef Ishani et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

添加到收藏夹

Article Immunology

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127(+) natural killer-like cells

Tom Cupedo et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹

Article Medicine, General & Internal

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

Frances Humby et al.

PLOS MEDICINE (2009)

添加到收藏夹

Article Gastroenterology & Hepatology

Lymphoid neogenesis and immune infiltration in aged liver

Pallavi Singh et al.

HEPATOLOGY (2008)

添加到收藏夹

Article Immunology

B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis

Tineke Cantaert et al.

JOURNAL OF IMMUNOLOGY (2008)

添加到收藏夹

Article Urology & Nephrology

Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis

Oliver M. Steinmetz et al.

KIDNEY INTERNATIONAL (2008)

添加到收藏夹

Article Immunology

B cells in cluster or in a scattered pattern do not correlate with clinical outcome of renal allograft rejection

Cornelis Scheepstra et al.

TRANSPLANTATION (2008)

添加到收藏夹

Article Surgery

CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival

S. M. Bagnasco et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2007)

添加到收藏夹

Article Rheumatology

Ectopic lymphoid neogenesis in psoriatic arthritis

Juan D. Canete et al.

ANNALS OF THE RHEUMATIC DISEASES (2007)

添加到收藏夹

Article Surgery

Acute cellular rejection with CD20-positive lymphoid clusters in kidney transplant patients following lymphocyte depletion

L. K. Kayler et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2007)

添加到收藏夹

Article Pathology

The contribution of B cells to renal interstitial inflammation

Florian Heller et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

添加到收藏夹

Article Medicine, Research & Experimental

Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis

Javier Rangel-Moreno et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

添加到收藏夹

Article Immunology

Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs

Juan E. Moyron-Quiroz et al.

IMMUNITY (2006)

添加到收藏夹

Review Immunology

Lymphoid organ development: from ontogeny to neogenesis

DL Drayton et al.

NATURE IMMUNOLOGY (2006)

添加到收藏夹

Review Urology & Nephrology

Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure

Masaomi Nangaku

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

添加到收藏夹

Article Rheumatology

Involvement of subchondral bone marrow in rheumatoid arthritis - Lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment

S Bugatti et al.

ARTHRITIS AND RHEUMATISM (2005)

添加到收藏夹

Article Urology & Nephrology

Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: Implications on tubulointerstitial inflammation in lupus nephritis

S Yung et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Lymphoid neogenesis in chronic rejection: Evidence for a local humoral alloimmune response

O Thaunat et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Review Immunology

Dendritic-cell trafficking to lymph nodes through lymphatic vessels

GJ Randolph et al.

NATURE REVIEWS IMMUNOLOGY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity

JE Moyron-Quiroz et al.

NATURE MEDICINE (2004)

添加到收藏夹

Article Medicine, General & Internal

The nature of small-airway obstruction in chronic obstructive pulmonary disease

JC Hogg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

添加到收藏夹

Review Oncology

Naturally occurring B-cell responses to breast cancer

JA Coronella-Wood et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2003)

添加到收藏夹

Article Medicine, General & Internal

Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling

M Sarwal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

添加到收藏夹

Article Immunology

Antigen-driven oligoclonal expansion of tumor-infiltrating B cells in infiltrating ductal carcinoma of the breast

JA Coronella et al.

JOURNAL OF IMMUNOLOGY (2002)

添加到收藏夹

Article Pathology

Thyroid autoimmune disease -: Demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers

MP Armengol et al.

AMERICAN JOURNAL OF PATHOLOGY (2001)

添加到收藏夹

Article Immunology

Lymphoid neogenesis in rheumatoid synovitis

S Takemura et al.

JOURNAL OF IMMUNOLOGY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.