Could leptin substitution therapy potentially terminate entrapment in anorexia nervosa?

Case studies of patients with anorexia nervosa revealed psychological improvements upon treatment with recombinant human leptin, including an alleviation of the entrapment in this eating disorder. Hypoleptinaemia induced by loss of adipose tissue mass might trigger psychological changes observed in starvation. Accordingly, leptin analogues might prove beneficial for treatment of anorexia nervosa.

Automated summary

Case studies have shown that treatment with recombinant human leptin in patients with anorexia nervosa can lead to psychological improvements, reducing the entrapment caused by this eating disorder. Hypoleptinemia induced by loss of adipose tissue mass may trigger the psychological changes observed in starvation, suggesting that leptin analogues may be beneficial for the treatment of anorexia nervosa.