Non-nutritional sweeteners and cardiovascular risk

Article Biochemistry & Molecular Biology

The artificial sweetener erythritol and cardiovascular event risk

Marco Witkowski et al.

Summary: Artificial sweeteners, especially erythritol, are associated with increased risk of major adverse cardiovascular events (MACE) and enhanced thrombosis formation. Ingestion of erythritol leads to elevated levels of erythritol in plasma, which is linked to heightened platelet reactivity and thrombosis potential. Further studies are needed to assess the long-term safety of erythritol.

NATURE MEDICINE (2023)

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Review Medicine, General & Internal

Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk A Systematic Review and Meta-analysis

Nema D. McGlynn et al.

Summary: This systematic review and meta-analysis found that using LNCSBs as a substitute for SSBs in overweight or obese adults at risk for or with diabetes was associated with small improvements in body weight and cardiometabolic risk factors without evidence of harm, and had a similar direction of benefit as water substitution.

JAMA NETWORK OPEN (2022)

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Article Biochemistry & Molecular Biology

Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

Jotham Suez et al.

Summary: This study found that the consumption of non-nutritive sweeteners (NNS) may alter the microbiome and glycemic responses in humans. Different NNS had distinct effects on the microbiome and glycemic responses, with saccharin and sucralose significantly impairing glycemic responses. Additionally, when NNS were supplemented to mice, the glycemic responses reflected those in respective human donors and were influenced by microbial signals.

CELL (2022)

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Article Medicine, General & Internal

Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Sante cohort

Charlotte Debras et al.

Summary: This large-scale prospective cohort study found a potential direct association between higher artificial sweetener consumption (especially aspartame, acesulfame potassium, and sucralose) and increased risk of cardiovascular diseases.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Review Biotechnology & Applied Microbiology