☆ 4.8 Editorial Material

Unmasking the elusive erythropoietin-producing 'Norn' cell

NATURE MEDICINE (2023)

Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations

Gregg L. Semenza

Summary: Red blood cells carry oxygen from the lungs to body tissues. Kidney cells secrete erythropoietin (EPO) in response to hypoxia, which increases red blood cell mass. Hypoxia-inducible factors (HIFs) activate the transcription of the EPO gene. Mutations in certain genes can cause familial erythrocytosis. Clinical trials have shown that HIF prolyl hydroxylase inhibitors are effective in stimulating erythropoiesis, but safety concerns have been raised regarding thromboembolism.

ANNUAL REVIEW OF MEDICINE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

The transcriptional and regulatory identity of erythropoietin producing cells

Bjort K. Kragesteen et al.

Summary: Single-cell RNA and transposase-accessible chromatin (ATAC) sequencing in a mouse model identified a rare cell subset called Norn cells in kidney stroma as the major source of endocrine Epo production in mice, and this finding was confirmed in human kidney tissues. These findings provide new insights into EPO gene regulation and may lead to improved therapies for anemia.

NATURE MEDICINE (2023)

添加到收藏夹

Article Medicine, General & Internal

Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis

Ajay K. Singh et al.

Summary: Among patients with CKD undergoing dialysis, daprodustat was found to be noninferior to ESAs in terms of change in hemoglobin levels and cardiovascular outcomes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Urology & Nephrology