☆ 4.8 Editorial Material

A synthetic tumour microenvironment

NATURE MATERIALS (2023)

Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas

Shivem B. Shah et al.

Summary: Using synthetic-hydrogel-based organoids, researchers identified that cellular and biophysical factors in the lymphoid tumor microenvironment (Ly-TME) dampen the efficacy of targeted therapies for DLBCL. Combinatorial inhibition of multiple aberrant signaling pathways showed higher antitumor efficacy in lymphoid organoids and implanted patient tumors. These studies define the crosstalk between malignant ABC-DLBCL cells and Ly-TME and provide rational combinatorial therapies to overcome treatment resistance mediated by Ly-TME.

NATURE MATERIALS (2023)

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Review Oncology

Towards targeting of shared mechanisms of cancer metastasis and therapy resistance

Felix Weiss et al.

Summary: Resistance to therapeutic treatment and metastatic progression are both important factors in determining the outcome of cancer. Recent evidence suggests that these two processes cooperate and reinforce each other. Various mechanisms, such as integrins, cell-cell communication, stress responses, and metabolic reprogramming, mediate the shared signals between metastasis and therapy resistance. Identifying these shared signaling networks could lead to more effective anticancer therapies.

NATURE REVIEWS CANCER (2022)

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Article Biochemistry & Molecular Biology