Ten things to know about NLRP10

The NLRP10 protein is found to form an inflammasome complex in response to mitochondrial damage. Loss of NLRP10 from colonic epithelia promotes inflammatory bowel disease in a mouse model, while a variant predisposing to atopic dermatitis also shows loss of function.

Automated summary

The NLRP10 protein forms an inflammasome complex in response to mitochondrial damage. The loss of NLRP10 in colonic epithelia promotes inflammatory bowel disease in a mouse model, while a variant associated with atopic dermatitis also exhibits loss of function.