Macrophage function in adipose tissue homeostasis and metabolic inflammation

Review Physiology

Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders

Triantafyllos Chavakis et al.

Summary: Inflammation-adapted hematopoietic stem and progenitor cells play a crucial role in emergency myelopoiesis, trained immunity, and clonal hematopoiesis. Modulation of HSPC function could lead to novel therapeutic interventions.

ANNUAL REVIEW OF PHYSIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Adipose-tissue plasticity in health and disease

Alexander Sakers et al.

Summary: Adipose tissue, known as fat, plays a crucial role in regulating various physiological aspects of the body. Its high plasticity allows for significant changes in metabolism, structure, and phenotype in response to physiological stimuli. Limitations in this plasticity contribute to decreased or aberrant responses to physiological cues, leading to the progression of cardiometabolic disease.

CELL (2022)

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Article Multidisciplinary Sciences

MicroRNA sequence codes for small extracellular vesicle release and cellular retention

Ruben Garcia-Martin et al.

Summary: Research has shown that miRNAs have sorting sequences that determine their secretion in sEVs, different cell types preferentially use specific sorting sequences to define their sEV miRNA profile. Insertion or deletion of these sequences affects miRNA secretion. RNA-binding proteins Alyref and Fus are involved in the mechanism, leading to enhanced miRNA delivery and inhibition of target genes in distant cells.

NATURE (2022)

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Article Cell Biology

Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism

Ruben Garcia-Martin et al.

Summary: Exosomes/small extracellular vesicles (sEVs) can mediate cell-to-cell communication through their miRNA and protein cargo. Each cell type has a unique sEV proteome, but there are also common markers. Specific markers of different cell types can predict the tissue of origin of serum sEVs, as demonstrated in a mouse model.

CELL REPORTS (2022)

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Article Medicine, Research & Experimental

Human CD206+ macrophages associate with diabetes and adipose tissue clusters

Lindsey A. Muir et al.

Summary: This study identified different subtypes of adipose tissue macrophages (ATMs) in obese and diabetic individuals and found that these subtypes play different roles in inflammation and insulin resistance. CD206(+)CD11c(-) ATMs were increased in diabetic participants and expressed proinflammatory cytokines and scavenger receptors, while the other two subtypes were lipid antigen presenting.

JCI INSIGHT (2022)

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Article Biochemistry & Molecular Biology

Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

Xiaofei Li et al.

Summary: Bone marrow-mediated trained innate immunity can enhance immune responsiveness, but maladaptive training can lead to inflammatory comorbidities. Periodontitis can induce maladaptive trained phenotype in the bone marrow, resulting in increased production of myeloid cells with inflammatory preparedness. The trained phenotype of the bone marrow can be transmitted to naive recipients through transplantation and lead to increased inflammatory responsiveness and disease severity. Inhibiting IL-1 signaling can prevent maladaptive training caused by periodontitis.

CELL (2022)

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Article Multidisciplinary Sciences

A single-cell atlas of human and mouse white adipose tissue

Margo P. Emont et al.

Summary: White adipose tissue, once considered bland, is now seen as dynamic, plastic and involved in various biological processes. High-fat feeding and other metabolic stressors lead to significant changes in adipose tissue, linked to insulin resistance, dyslipidemia and type 2 diabetes. Research provides detailed cellular atlases of human and mouse adipose tissue, highlighting interactions between different cell types in lean and obese states.

NATURE (2022)

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Article Multidisciplinary Sciences

Obesity alters pathology and treatment response in inflammatory disease

Sagar P. Bapat et al.

Summary: Obesity can disrupt immune responses and alter the effectiveness of immunotherapies by changing T cell immune reactions and decreasing the activity of PPAR gamma in Th2 cells.

NATURE (2022)

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Review Biotechnology & Applied Microbiology

Drugging the efferocytosis process: concepts and opportunities

Parul Mehrotra et al.

Summary: This article discusses the mechanisms and role of efferocytosis in diseases, as well as evaluates strategies and agents for therapeutic intervention. Efferocytosis is crucial for maintaining homeostasis by removing apoptotic cells and promoting resolution. Abnormalities in efferocytosis are associated with various inflammatory pathologies, making it an important target for interventions. The recent discoveries in molecular machinery involved in efferocytosis have opened up new avenues for therapeutic development.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Multidisciplinary Sciences

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice

Matthew A. Cottam et al.

Summary: The imprinting of AT immune cells that occurs in obesity persists during weight loss and worsens with weight regain, leading to impaired recovery of regulatory cells, activation of antigen presenting cells, T cell exhaustion, and enhanced lipid handling in macrophages. Understanding these immunological causes of weight cycling-accelerated metabolic disease is crucial.

NATURE COMMUNICATIONS (2022)

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Article Endocrinology & Metabolism

Adipose Tissue Myeloid-Lineage Neuroimmune Cells Express Genes Important for Neural Plasticity and Regulate Adipose Innervation

Magdalena Blaszkiewicz et al.

Summary: Peripheral nerves play a crucial role in the communication and regulation between the brain and adipose tissues. Neuroimmune cells, particularly in subcutaneous white adipose tissue, have been found to support the nerve supply and metabolic functions of adipose tissue. Cold-induced neuroimmune cells have been identified to express brain-derived neurotrophic factor (BDNF) and promote neurite density in adipose tissue. Knockout of BDNF in myeloid-lineage cells resulted in decreased innervation of adipose tissue, impaired thermogenesis, and increased adiposity. In contrast, knockout of BDNF in a specific macrophage subset resulted in increased thermogenesis and energy expenditure. These findings suggest a homeostatic role of myeloid-lineage neuroimmune cells in adipose tissue regulation and energy expenditure.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Editorial Material Neurosciences

Exon 2-mediated deletion of Trem2 does not worsen metabolic function in diet-induced obese mice

Nathan C. Winn et al.

Summary: Trem2, highly expressed on myeloid cells, is involved in lipid homeostasis and inflammation. This study aimed to determine the causal role of Trem2 in regulating glucose homeostasis and insulin sensitivity in mice.

JOURNAL OF PHYSIOLOGY-LONDON (2022)

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Article Cell Biology

Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution

Anitta Kinga Sarvari et al.

Summary: The study utilized single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose tissue in response to high-fat-diet-induced obesity, revealing changes in adipocyte subpopulations and increased lipid-handling genes in macrophages with obesity.

CELL METABOLISM (2021)

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Article Cell Biology

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Sabine Daemen et al.

Summary: The study reveals that changes in liver macrophage subsets during the pathogenesis of NASH are dynamically linked to pathologic tissue remodeling. High-fat, high-sucrose-diet feeding leads to a decrease in mature TIM4(pos) Kupffer cells (KCs) and an accumulation of monocyte-derived Tim4(neg) macrophages in the liver. Additionally, C-LAMs expressing Cx3cr1/Ccr2 fail to appear in the liver in Ccr2-deficient mice, preventing the formation of hCLS and resulting in increased liver fibrosis.

CELL REPORTS (2021)

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Article Immunology

Myeloid Cell-Specific IL-4 Receptor Knockout Partially Protects from Adipose Tissue Inflammation

Jan Ackermann et al.

Summary: This study suggests that IL-4 receptor signaling plays a minor role in maintaining the macrophage M2 population and proliferation rates in vivo, while IL-4 signaling exerts a proinflammatory role in adipose tissue inflammation by directly upregulating CD11c on adipose tissue macrophages.

JOURNAL OF IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Single-cell RNA sequencing reveals the induction of novel myeloid and myeloid-associated cell populations in visceral fat with long-term obesity

Natalia S. Harasymowicz et al.

Summary: This study identified 11 unique myeloid and myeloid-associate cell populations in mouse adipose tissue through single-cell RNA sequencing, immunofluorescence, and flow cytometry. The research revealed changes in various cell populations in obese mice and identified a novel myeloid/macrophage population with pro-fibrotic characteristics.

FASEB JOURNAL (2021)

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Article Medicine, Research & Experimental

Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells

Iacopo Gesmundo et al.

Summary: Healthy adipocyte-derived EVs are beneficial for beta cell survival and function, while EVs from inflamed adipocytes cause beta cell death and dysfunction. Lean adipocyte-derived EVs have similar beneficial effects, whereas EVs from obese adipose tissue are harmful for beta cells. Differential expression of miRNAs and alterations in signaling pathways and gene expression in recipient beta cells were observed, suggesting that adipocyte-derived EVs may influence beta cell fate and function depending on the physiological and pathological state of adipose tissue.

JCI INSIGHT (2021)

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Article Immunology

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

Andrew D. Hildreth et al.

Summary: This study provides a comprehensive analysis of the cellular composition in healthy and obese human white adipose tissue, revealing changes in immune cell populations and inflammatory pathways in obese individuals. The findings highlight the importance of immune cell regulation in metabolic diseases and offer insights into new cellular networks and differentiation trajectories in white adipose tissue.

NATURE IMMUNOLOGY (2021)

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Review Physiology

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions

Yunnan Liu et al.

Summary: Adipose tissue secreted exosomes are crucial in transmitting information and exerting physiological and pathological effects on different organs. They also hold potential therapeutic significance.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Acetylcholine-synthesizing macrophages in subcutaneous fat are regulated by β2-adrenergic signaling

Alexander J. Knights et al.

Summary: This study demonstrates that macrophages play a crucial role in regulating thermogenesis by secreting acetylcholine in adipose tissue. The abundance of ChAMs increases in response to acute cold exposure, and their regulation is mediated through adrenergic signaling. Deletion of the enzyme ChAT impairs cold-induced thermogenesis in mice.

EMBO JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice

Qi Chen et al.

Summary: Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to metabolic changes and play a protective role against pathological remodeling during obesity. They control vascular integrity, adipocyte function, lipid metabolism, extracellular matrix accumulation, and fibrosis in WAT. The protective role of ATMs in obesity-driven WAT dysfunction challenges the traditional assumption of them as foes.

EMBO REPORTS (2021)

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Article Multidisciplinary Sciences

Diet-regulated production of PDGFcc by macrophages controls energy storage

Nehemiah Cox et al.

Summary: This study identified a macrophage-dependent mechanism involving the PDGFcc ortholog that controls lipid storage in adipose tissues of mice. Production of PDGFcc is regulated by diet and blocking PDGFcc leads to redirection of excess lipids toward thermogenesis in brown fat.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels

M. S. Magalhaes et al.

Summary: The research suggests that Tim4 plays a key regulatory role in resident adipose tissue macrophages, leading to specific transcriptional activation and affecting cholesterol transport after lipid ingestion. This provides a new pathway for treating dyslipidemia.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

Leen Catrysse et al.

Summary: The study found that myeloid-specific A20-deficient mice are protected from diet-induced obesity and insulin resistance despite the presence of an inflammatory environment in their metabolic tissues. Macrophages lacking A20 show impaired mitochondrial respiratory function and metabolize more palmitate, resulting in a lean phenotype and protection from metabolic disease. These findings suggest a role for A20 in regulating macrophage immunometabolism.

CELL REPORTS (2021)

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Article Immunology

Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue

Ines Felix et al.

Summary: This study reveals the diversity and developmental origin of resident adipose tissue macrophages through comprehensive single-cell mass cytometry analysis, as well as the functional differences in their in vitro and in vivo activities. A high-fat diet induces changes in the quantity and functionality of macrophages, which can be reversed by dietary intervention.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Endocrinology & Metabolism

Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function

Kasparas Petkevicius et al.

Summary: The study revealed that neuroimmune interactions between the sympathetic nervous system and macrophages do not directly modulate the phenotype of adipose tissue macrophages in mice, but rather exert an indirect effect through the modulation of adipocyte function.

MOLECULAR METABOLISM (2021)

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Review Cell Biology

Adipose Tissue Immunometabolism and Apoptotic Cell Clearance

Tamas Roeszer

Summary: The safe removal of apoptotic cells by macrophages is crucial for tissue health, but in the case of adipocyte apoptosis, the clearance process can lead to inflammation and metabolic diseases. Metabolites released by apoptotic cells and produced by macrophages during digestion of apoptotic cells control macrophage immune functions.

CELLS (2021)

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Article Endocrinology & Metabolism

Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue

Yi-Na Wang et al.

Summary: Slit3, secreted by adipose tissue macrophages, promotes cold adaptation by stimulating sympathetic innervation and thermogenesis in mice. The interaction between Slit3 and sympathetic neurons enhances adipocyte thermogenesis. These findings highlight the crucial role of M2-like macrophages in adipose tissue homeostasis and the regulation of long-term cold adaptation through the macrophage-Slit3-sympathetic neuron-adipocyte signalling axis.

NATURE METABOLISM (2021)

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Article Cell Biology

Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome

Qiang Qin et al.

Summary: In this study, it was found that the expression of Stk24 is significantly downregulated in ATMs in obese individuals or those with type 2 diabetes, as well as in mice fed a high-fat diet. Stk24 deficiency exacerbates HFD-induced metabolic disorders and insulin insensitivity. Stk24 plays a role in regulating NLRP3 inflammasome assembly in ATMs, and its expression correlates negatively with body mass index and related indicators in human subjects.

CELL REPORTS (2021)

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Article Endocrinology & Metabolism

TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response

Jinyoung Kim et al.

Summary: Kim et al. demonstrate that TFEB expression plays a protective role in diet-induced obesity by activating GDF15. Overexpression of TFEB can alleviate diet-induced obesity, while its deletion can exacerbate adipose tissue inflammation and insulin resistance.

NATURE METABOLISM (2021)

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Article Endocrinology & Metabolism

Multinucleated Giant Cells in Adipose Tissue Are Specialized in Adipocyte Degradation

Julia Braune et al.

Summary: This study identified multinucleated giant cells (MGCs) in obese patients and mice fed a high-fat diet, showing that MGCs have a higher capacity to phagocytize dead adipocytes. Mechanistically, adipocyte death triggers the formation of MGCs, suggesting that MGCs are specialized for clearing dead adipocytes in obesity.

DIABETES (2021)

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Review Immunology

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Ioannis Kourtzelis et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Letter Cell Biology

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Hui Gao et al.

CELL METABOLISM (2020)

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Article Immunology

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

Anneleen Remmerie et al.

IMMUNITY (2020)

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Article Endocrinology & Metabolism

Prolonged fasting drives a program of metabolic in fl ammation in human adipose tissue

Pouneh K. Fazeli et al.

MOLECULAR METABOLISM (2020)

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Article Endocrinology & Metabolism

Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity

Bo Shan et al.

NATURE METABOLISM (2020)

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Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Endocrinology & Metabolism

Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Jinchu Vijay et al.

NATURE METABOLISM (2020)

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Article Immunology

Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges

Hernandez Moura Silva et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Review Endocrinology & Metabolism

Obesity: global epidemiology and pathogenesis

Matthias Blueher

NATURE REVIEWS ENDOCRINOLOGY (2019)

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Article Multidisciplinary Sciences

A lipase-independent pathway of lipid release and immune modulation by adipocytes

Stephen E. Flaherty et al.

SCIENCE (2019)

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Article Multidisciplinary Sciences

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Svetoslav Chakarov et al.

SCIENCE (2019)

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Article Biochemistry & Molecular Biology

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

Diego Adhemar Jaitin et al.

CELL (2019)

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Review Immunology

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

Triantafyllos Chavakis et al.

NATURE IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy

Joshua C. Chang et al.

SCIENTIFIC REPORTS (2019)

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Review Medicine, Research & Experimental

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

C. Ronald Kahn et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Multidisciplinary Sciences

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

P. Ramachandran et al.

NATURE (2019)

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Article Biochemistry & Molecular Biology

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

Vanessa Frodermann et al.

NATURE MEDICINE (2019)

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Review Immunology

Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity?

Sider Penkov et al.

TRENDS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

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Article Gastroenterology & Hepatology

CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease

Richard Parker et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Anette Christ et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Ioannis Mitroulis et al.

CELL (2018)

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Article Endocrinology & Metabolism

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

Lily Boutens et al.

DIABETOLOGIA (2018)

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Review Medicine, Research & Experimental

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

Charles N. Serhan et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Cardiac & Cardiovascular Systems

Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes

Brendan M. Everett et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Multidisciplinary Sciences

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

David A. Hill et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Multidisciplinary Sciences

Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4

Ailing Liu et al.

NATURE COMMUNICATIONS (2018)

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Article Immunology

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

Selma Boulenouar et al.

IMMUNITY (2017)

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Review Medicine, Research & Experimental

Skeletal muscle inflammation and insulin resistance in obesity

Huaizhu Wu et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Review Medicine, Research & Experimental

Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk

Allison B. Goldfine et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Multidisciplinary Sciences

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

Christina D. Camell et al.

NATURE (2017)

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Article Biochemistry & Molecular Biology

Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine

Roksana M. Pirzgalska et al.

NATURE MEDICINE (2017)

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Article Medicine, General & Internal

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

P. M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Cell Biology

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

Kenny L. Chan et al.

CELL REPORTS (2017)

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Article Cell Biology

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

Brittney R. Coats et al.

CELL REPORTS (2017)

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Article Cell Biology

Inhibition of IKK 3 and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes

Elif A. Oral et al.

CELL METABOLISM (2017)

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Article Immunology

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

Kyoung-Jin Chung et al.

NATURE IMMUNOLOGY (2017)

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Article Immunology

The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity

Bo Shan et al.

NATURE IMMUNOLOGY (2017)

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Article Cell Biology

A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis

Genevieve Marcelin et al.

CELL METABOLISM (2017)

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Article Cell Biology

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity

Byung-Cheol Lee et al.

CELL METABOLISM (2016)

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Article Immunology

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance

Kae Won Cho et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation

Abigail S. Haka et al.

JOURNAL OF LIPID RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

Rongrong Fan et al.

NATURE MEDICINE (2016)

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Article Medicine, Research & Experimental

Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice

Jongkil Kim et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2016)

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Article Endocrinology & Metabolism

Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss

J. Schmitz et al.

MOLECULAR METABOLISM (2016)

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Article Multidisciplinary Sciences

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

Sachiko Nishimoto et al.

SCIENCE ADVANCES (2016)

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Article Biochemistry & Molecular Biology

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

Min-Woo Lee et al.

CELL (2015)

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Article Cell Biology

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche

Yubin Luo et al.

CELL METABOLISM (2015)

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Article Endocrinology & Metabolism

Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages

Lijun Tang et al.

ENDOCRINOLOGY (2015)

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Article Immunology

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

Felix M. Wensveen et al.

NATURE IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

Elise Dalmas et al.

NATURE MEDICINE (2015)

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Article Endocrinology & Metabolism

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Promotes Adipogenesis and Diet-Induced Obesity

Min Park et al.

DIABETES (2015)

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Article Multidisciplinary Sciences

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Jonathan R. Brestoff et al.

NATURE (2015)

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Review Immunology

Cholesterol, inflammation and innate immunity

Alan R. Tall et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

Rajesh R. Rao et al.

CELL (2014)

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Article Biochemistry & Molecular Biology

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

Yun Sok Lee et al.

CELL (2014)

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Article Cell Biology

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

Prabhakara R. Nagareddy et al.

CELL METABOLISM (2014)

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Article Cell Biology

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

Mario Kratz et al.

CELL METABOLISM (2014)

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Article Cell Biology

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

Shinya U. Amano et al.

CELL METABOLISM (2014)

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Article Endocrinology & Metabolism

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

Julia Haase et al.

DIABETOLOGIA (2014)

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Article Biochemistry & Molecular Biology

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

Bhama Ramkhelawon et al.

NATURE MEDICINE (2014)

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Review Medicine, General & Internal

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

Gerald I. Shulman

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Endocrinology & Metabolism

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

Kanakadurga Singer et al.

MOLECULAR METABOLISM (2014)

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